DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and CG4950

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	101/413 - (24%)
Similarity:	169/413 - (40%)	Gaps:	100/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ELELNAPANKLNLTHRDLRTFNSTGGQWKG--DFQVITAMDLSSNQLESLSLDNF---NQLRQLD 148
            ||..||.:...|||:.:|...|.|..|...  ...|:..:|||.|::.|||::.|   :.:.|:.
  Fly   108 ELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIY 172

  Fly   149 LGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESF 213
            |..|.|:.:...:...|..|..|:.:  .|..:.|....| :.:.::|.:||::|.|:.|..::|
  Fly   173 LTGNLLKELHNDIFKDNEYLEKVSFE--GNLLTSIQPEVF-RNMRRIKEVNLSNNRLIFIHPDTF 234

  Fly   214 YNLLELQTLVLSHNNIS---------------DIDYETFLALPNLQYLDLSHNRLSG-------- 255
            .:...|:.||||:|.:.               |.:|.|.|.:...:::..|||::|.
  Fly   235 ADAASLENLVLSYNELKNFQLTEKNIVHQLHLDNNYLTNLTINATRFVRASHNQISELFLHQSLH 299

  Fly   256 -----------SAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALA 309
                       |:|..:..|..::.|.::.||...:.:..|.....|:.|:..|||
  Fly   300 IETLDLSANKLSSISNITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTG--------- 355

  Fly   310 QSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVE-DDALGRLELLESLFLDRNLLMRV 373
              :|.||.          |.......|:.||||.:.:..:. |..:..|..|:...:|.|.|..
  Fly   356 --IRELKF----------GMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTE- 407

  Fly   374 PSSLPPSLEHLFLQHNQ-IMELPPQAFVGLVNLQTLDLSNNRL-------IFLPPLSLPKLLTLN 430
                        ||.|: ..|..||       ||.|.:|.||.       :.:|| |||:.:.||
  Fly   408 ------------LQGNRTFSEAFPQ-------LQKLGVSRNRFNCSYLHHLLIPP-SLPESVVLN 452

  Fly   431 LESSGVESVSQSIVHTLPQLRDL 453
            :|       ..:.:...|.:||:
  Fly   453 IE-------PDTNLDETPHIRDV 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	61/268 (23%)
		leucine-rich repeat	124..143	CDD:275380	8/21 (38%)
		leucine-rich repeat	144..167	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..194	CDD:275380	3/21 (14%)
		LRR_8	193..253	CDD:290566	20/74 (27%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..242	CDD:275380	10/37 (27%)
		LRR_8	241..301	CDD:290566	15/78 (19%)
		leucine-rich repeat	243..311	CDD:275380	16/86 (19%)
		leucine-rich repeat	312..335	CDD:275380	4/22 (18%)
		LRR_8	334..415	CDD:290566	22/82 (27%)
		leucine-rich repeat	336..359	CDD:275380	7/23 (30%)
		leucine-rich repeat	360..380	CDD:275380	4/19 (21%)
		LRR_8	379..460	CDD:290566	23/83 (28%)
		LRR_4	379..>415	CDD:289563	11/36 (31%)
		leucine-rich repeat	381..404	CDD:275380	6/23 (26%)
		leucine-rich repeat	405..449	CDD:275380	14/50 (28%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	4/10 (40%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	168..191	CDD:275380	5/22 (23%)
		LRR_8	192..250	CDD:290566	18/60 (30%)
		leucine-rich repeat	192..215	CDD:275380	5/25 (20%)
		LRR_RI	<207..432	CDD:238064	61/266 (23%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	14/58 (24%)
		LRR_8	299..356	CDD:290566	12/67 (18%)
		leucine-rich repeat	300..321	CDD:275380	3/20 (15%)
		leucine-rich repeat	322..345	CDD:275380	4/22 (18%)
		LRR_8	344..405	CDD:290566	19/81 (23%)
		leucine-rich repeat	346..365	CDD:275380	9/39 (23%)
		leucine-rich repeat	370..394	CDD:275380	7/23 (30%)
		leucine-rich repeat	395..420	CDD:275380	8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940