DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 2mit and CG32055

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	143/569 - (25%)
Similarity:	213/569 - (37%)	Gaps:	191/569 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKIVNQHCDL---------GLALLLA------------------WTWLTRLVVAAHLVDIPTSSR 39
            ||:||:|..:         ||:.||.                  :..|.:|.:        |.::
  Fly    53 VKVVNEHTGIERAEDGELPGLSTLLQLDLSESGGVTLGEKGLQDFKALQKLNL--------THAQ 109

  Fly    40 LAAEREEQ----------QLSRQDV-----------GRLSYQSIHRMLRDENEPDSFR--GELRY 81
            |...:.||          .:|..|:           |.|.|.:....|....||::||  ..||:
  Fly   110 LDELKSEQFPNPSEMINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRF 174

  Fly    82 QQ--KRHKRELELNAPANK--LNLTHRDLRTFNSTGGQWKGDFQVITAMD---LSSNQLESLSLD 139
            ..  ..::..:.|...||.  |::::.:||.|     || ...:|:..::   |.||.||.|.:.
  Fly   175 LDLTTNYQENITLGENANLRFLSISNNNLRDF-----QW-CHLRVLPKLEELHLHSNWLEHLDMG 233

  Fly   140 NF---NQLRQLDLGNNSL------------EVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFA 189
            .|   ..||.|::.||:|            |:.||.|           ||.|.|....:..|.|.
  Fly   234 IFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLEL-----------LDYSSNIVKVLDDSVFC 287

  Fly   190 QRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLS 254
             ||.:|:.|||..|::..|...:|..|..||||.|..|.||.:..:.|..|..|:.||||.|.:.
  Fly   288 -RLKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQ 351

  Fly   255 GSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSD 319
            ...:|..                                                 ..|.|:
  Fly   352 KLGLRVF-------------------------------------------------GERILR--- 364

  Fly   320 NWLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLL----MRVPSSLPPS 380
                           .|.|||||::.||.:...||..:..::.|.|.||.|    :|:.:.| ..
  Fly   365 ---------------KLIYLDLSNNYIADLHPLALSSMPFIKELRLRRNRLVSLDLRMFAPL-RQ 413

  Fly   381 LEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVESVSQSIVH 445
            |:.|.:..|::.|:..:....|..|..|:|:||||.|||          :|:||          .
  Fly   414 LQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLP----------DLKSS----------Q 458

  Fly   446 TLPQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDL 494
            .|.|||::.||.||.:|..|..|..|.:. |.|...:.:.|..|||..|
  Fly   459 NLLQLRNITLEGNPWQCLCLDEITSWLNG-RHVSYARPSSAYFSGRKPL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	61/248 (25%)
		leucine-rich repeat	124..143	CDD:275380	7/24 (29%)
		leucine-rich repeat	144..167	CDD:275380	10/34 (29%)
		leucine-rich repeat	172..194	CDD:275380	8/21 (38%)
		LRR_8	193..253	CDD:290566	24/59 (41%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	10/22 (45%)
		LRR_8	241..301	CDD:290566	7/59 (12%)
		leucine-rich repeat	243..311	CDD:275380	7/67 (10%)
		leucine-rich repeat	312..335	CDD:275380	2/22 (9%)
		LRR_8	334..415	CDD:290566	27/84 (32%)
		leucine-rich repeat	336..359	CDD:275380	10/22 (45%)
		leucine-rich repeat	360..380	CDD:275380	7/23 (30%)
		LRR_8	379..460	CDD:290566	25/80 (31%)
		LRR_4	379..>415	CDD:289563	10/35 (29%)
		leucine-rich repeat	381..404	CDD:275380	5/22 (23%)
		leucine-rich repeat	405..449	CDD:275380	14/43 (33%)
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380	2/22 (9%)
		leucine-rich repeat	100..123	CDD:275380	6/30 (20%)
		LRR_8	128..180	CDD:290566	12/51 (24%)
		leucine-rich repeat	128..147	CDD:275380	2/18 (11%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..192	CDD:275380	3/19 (16%)
		LRR_RI	<187..400	CDD:238064	76/297 (26%)
		LRR_8	192..251	CDD:290566	20/64 (31%)
		leucine-rich repeat	193..216	CDD:275380	7/28 (25%)
		leucine-rich repeat	217..240	CDD:275380	7/22 (32%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	10/34 (29%)
		LRR_8	290..350	CDD:290566	24/59 (41%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..339	CDD:275380	10/22 (45%)
		LRR_8	340..400	CDD:290566	23/126 (18%)
		leucine-rich repeat	340..365	CDD:275380	9/91 (10%)
		leucine-rich repeat	366..389	CDD:275380	10/22 (45%)
		leucine-rich repeat	390..413	CDD:275380	7/23 (30%)
		LRR_8	391..448	CDD:290566	17/57 (30%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930