DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and CG6749

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	126/457 - (27%)
Similarity:	180/457 - (39%)	Gaps:	132/457 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SRQDVGRLSYQSIH----RMLRDENEPDSFRGELRYQQKRHKRELELN--APANKLNLTHR---- 104
            |.||:..|..::.|    |.::.|.|..|  || ......:..:|:|.  ||.|    .|.
  Fly    44 SLQDLVDLGAENWHTLAIRNVQTELEVGS--GE-NADHLANLLDLDLTGAAPIN----VHTNGFS 101

  Fly   105 ---DLRTFNSTG-------GQWKGDFQVITAMDLSSNQLESLSLDNFNQLRQL---DLGNNSLEV 156
               :||..|.:|       |........:..:|.|.||:|.|..|.|..||:|   :..:|:|:
  Fly   102 ILPNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALK- 165

  Fly   157 IPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQT 221
                    ...||                     .:|.|..|.|.||.|:|   .:|....:||.
  Fly   166 --------QCDLP---------------------HMPLLNRLELGHNRLVN---ATFGVCPQLQE 198

  Fly   222 LVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYN------PDVGV 280
            |:|:.|.:..:|...|..|..|..|.||.||||...:...|.:..|..|:::.|      |:|..
  Fly   199 LILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIGLETFQPLAQLRKLNLSQNALDALRPNVFG 263

  Fly   281 AMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSR 345
            |:|.||.  .|::||.||.             |...|.||..:.:        ..||.||:|.:.
  Fly   264 AVQNFVL--HLQQLDLSGN-------------RIRLLFDNQFRVL--------ARLQMLDVSRNS 305

  Fly   346 IAQVEDDALGRLELLESLFLDRNLLMRVPSSLPP-------SLEHLFLQHNQIMELPPQAFVGLV 403
            ||                            ||.|       ||..|:||:|.|:|:.|..|..|:
  Fly   306 IA----------------------------SLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALL 342

  Fly   404 NLQTLDLSNNRLIFLPPL-----SLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCS 463
            ||.|||||.|.|.||...     :||::..|||..:.::.:......:||.|..|.|..|.:|..
  Fly   343 NLDTLDLSYNNLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSL 407

  Fly   464 DL 465
            |:
  Fly   408 DV 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	66/239 (28%)
		leucine-rich repeat	124..143	CDD:275380	8/18 (44%)
		leucine-rich repeat	144..167	CDD:275380	5/25 (20%)
		leucine-rich repeat	172..194	CDD:275380	0/21 (0%)
		LRR_8	193..253	CDD:290566	22/59 (37%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_8	241..301	CDD:290566	23/65 (35%)
		leucine-rich repeat	243..311	CDD:275380	23/73 (32%)
		leucine-rich repeat	312..335	CDD:275380	4/22 (18%)
		LRR_8	334..415	CDD:290566	29/87 (33%)
		leucine-rich repeat	336..359	CDD:275380	7/22 (32%)
		leucine-rich repeat	360..380	CDD:275380	3/26 (12%)
		LRR_8	379..460	CDD:290566	34/92 (37%)
		LRR_4	379..>415	CDD:289563	20/42 (48%)
		leucine-rich repeat	381..404	CDD:275380	10/22 (45%)
		leucine-rich repeat	405..449	CDD:275380	16/48 (33%)
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	49/185 (26%)
		LRR_8	104..164	CDD:290566	17/59 (29%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	9/22 (41%)
		leucine-rich repeat	154..195	CDD:275380	14/73 (19%)
		LRR_RI	194..455	CDD:238064	80/267 (30%)
		LRR_8	194..254	CDD:290566	20/59 (34%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	9/22 (41%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR_8	271..330	CDD:290566	25/107 (23%)
		leucine-rich repeat	272..295	CDD:275380	9/43 (21%)
		leucine-rich repeat	296..319	CDD:275380	10/50 (20%)
		LRR_8	319..380	CDD:290566	27/60 (45%)
		leucine-rich repeat	320..343	CDD:275380	10/22 (45%)
		leucine-rich repeat	344..369	CDD:275380	11/24 (46%)
		LRR_8	368..428	CDD:290566	12/42 (29%)
		leucine-rich repeat	370..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..417	CDD:275380	6/16 (38%)
		leucine-rich repeat	418..441	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472904
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940