DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and ltl

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	199/946 - (21%)
Similarity:	331/946 - (34%)	Gaps:	311/946 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NKLNLTHRDLRTFNSTGGQWKGDFQVITAMDL--SSNQLESLSLD-----NFNQLRQLDLGNNSL 154
            |.:.|:...|.:||:............|.:||  :.:||:.|.:.     ||| |.:|.:..|||
  Fly    34 NHVELSCEKLESFNAVVDSLANKLNADTNIDLKITHSQLDDLEMRSFTDMNFN-LYKLRMQWNSL 97

  Fly   155 EVIP------------LSLADTNMS---------LP-FVTLDLSCNKFSQISTSFFAQRLPQLKN 197
            :.:|            ||:.|.::.         :| .:|||:...|...:....| :.:.::.|
  Fly    98 KSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDF-RGIQRVTN 161

  Fly   198 LNLAHNELLNISRESF---------------------YNLLELQTLVLSHNNISDIDYETFLALP 241
            |.|..|.:..:.|.||                     ::|..|::|.::.|||:.:|.|    ||
  Fly   162 LILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDE----LP 222

  Fly   242 N---LQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNP--------DVGVAMQEFVASWSLKELD 295
            :   |:.|...:|||...... :.|:..|.::.|..|.        ...|.:.|.:|  ...||:
  Fly   223 DGGQLRLLMAHNNRLERLPAN-MAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMA--DNNELE 284

  Fly   296 ASGTGLCQVPAALAQSVRTLKLSDNWLKAINC---------------GDMDSYPL--------LQ 337
            .    |.|...|....|.||::..|.:|::|.               .|::.:.:        |:
  Fly   285 Y----LAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLK 345

  Fly   338 YLDLSHSRIAQVEDDALGRLEL-LESLFLDRNLLMRVPSSLP--PSLEHLFLQHNQIMELPPQAF 399
            .|.||.:||.::..|..|..|| |.:|.||.|.:..:..:|.  .:|..|.|..|::..|....|
  Fly   346 TLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDF 410

  Fly   400 VGLVNLQTLDLSNNRLIFLPPL--------------------------SLPKLLTLNLESSGVES 438
            .|::.|..|||:.|:|..|.||                          .||.|...||.::.:.:
  Fly   411 DGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQIST 475

  Fly   439 VSQSIV-------HTLPQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDLKT 496
            :|..:|       |.:|...::.|:||||.|.  :|:.|.   ||.:...:   |.:.||
  Fly   476 ISSELVTNTRCKNHNVPGKLEIHLDDNPIMCD--VGLNEL---CRLMAVQE---ARIRGR----- 527

  Fly   497 EYLQFHNFYENFSSRECGIRKPENDTKPPSCSLTRASATLTTTPRSMSKVEKSQEAQATATSVEV 561
                 ...:|| ....|.:.....:...| ..:|....|....|:.|.:|
  Fly   528 -----SQCFEN-DQEVCTVLPMLYNVNLP-IMVTNLKLTGREVPKPMVRV--------------- 570

  Fly   562 AAATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGNIPAQLTT 626
                                           .:.:...::....|.|     |.:.|| |..::|
  Fly   571 -------------------------------IVPSLIKANNELLPPL-----IATLGN-PVLIST 598

  Fly   627 KTLRPTETTSLAQLQRRQQMPGMPAKTTETPAKNLP---SLAQTKATTALPILATRDAATATTEI 688
            ..:.|.    ::.|    ..|.:.|.||..|...||   .:.:.::|||.|:         .|..
  Fly   599 DLVNPV----ISPL----PPPLLLATTTPPPPLPLPVESEVEKNESTTANPV---------PTNY 646

  Fly   689 NSDKPTNISGATKTVATSAAEIATPPAIEVPQTILAGKKSDKMPADKAHETLLKYPTRDTSGQVA 753
            ..:..|..|..|.|..|..:....|  ||:..|..                    ||..|:.  .
  Fly   647 TQETTTTTSTTTTTTTTETSSQVAP--IEIITTTA--------------------PTTTTTS--T 687

  Fly   754 TTPHKHATLQLHVKDRHLIGTPLLMHKGDVLLVDA---EQLLLPGTATVADADSEVLDPSQQHQS 815
            |||..:.||            |:::...|....|.   :..|:|..         ||||.||...
  Fly   688 TTPKPNETL------------PVIVELQDPNPPDTTVNQTALVPPV---------VLDPLQQDLE 731

  Fly   816 AEQEKHQSATDKRQAD---------------------AINGD--TKSPAKGHKKKPSLSIKKMTY 857
            .|:|:.:....:|..|                     .:..|  |..|:|.:
  Fly   732 RERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKAN------------- 783

  Fly   858 STKHAAKTVEDMAATSKTPQHQHSSVNTPKEAAPEE 893
            :.:..:::|...:..::.| |...|:..|:| .|||
  Fly   784 ALEEDSESVHSNSVHAEYP-HAAQSLQIPEE-PPEE 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	72/314 (23%)
		leucine-rich repeat	124..143	CDD:275380	8/25 (32%)
		leucine-rich repeat	144..167	CDD:275380	9/34 (26%)
		leucine-rich repeat	172..194	CDD:275380	5/21 (24%)
		LRR_8	193..253	CDD:290566	20/83 (24%)
		leucine-rich repeat	195..218	CDD:275380	8/43 (19%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_8	241..301	CDD:290566	15/70 (21%)
		leucine-rich repeat	243..311	CDD:275380	17/75 (23%)
		leucine-rich repeat	312..335	CDD:275380	7/37 (19%)
		LRR_8	334..415	CDD:290566	28/91 (31%)
		leucine-rich repeat	336..359	CDD:275380	8/22 (36%)
		leucine-rich repeat	360..380	CDD:275380	6/21 (29%)
		LRR_8	379..460	CDD:290566	28/113 (25%)
		LRR_4	379..>415	CDD:289563	12/35 (34%)
		leucine-rich repeat	381..404	CDD:275380	7/22 (32%)
		leucine-rich repeat	405..449	CDD:275380	17/76 (22%)
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	5/20 (25%)
		LRR_8	86..145	CDD:290566	14/59 (24%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		leucine-rich repeat	135..158	CDD:275380	5/23 (22%)
		LRR_8	158..214	CDD:290566	11/55 (20%)
		leucine-rich repeat	159..180	CDD:275380	7/20 (35%)
		leucine-rich repeat	181..203	CDD:275380	1/21 (5%)
		leucine-rich repeat	204..226	CDD:275380	9/25 (36%)
		LRR_RI	226..451	CDD:238064	56/231 (24%)
		leucine-rich repeat	227..249	CDD:275380	6/22 (27%)
		leucine-rich repeat	250..272	CDD:275380	3/21 (14%)
		leucine-rich repeat	273..296	CDD:275380	7/28 (25%)
		leucine-rich repeat	297..315	CDD:275380	6/17 (35%)
		LRR_8	319..402	CDD:290566	21/82 (26%)
		leucine-rich repeat	320..335	CDD:275378	1/14 (7%)
		leucine-rich repeat	344..366	CDD:275380	8/21 (38%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		LRR_8	369..426	CDD:290566	18/56 (32%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		LRR_8	438..>479	CDD:290566	6/40 (15%)
		leucine-rich repeat	440..462	CDD:275380	1/21 (5%)
		leucine-rich repeat	463..483	CDD:275380	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453605
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840