DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and rdo

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	164/660 - (24%)
Similarity:	237/660 - (35%)	Gaps:	152/660 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 QLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAI 258
            :|:.|.:..:.|..|..|||:.|..|:.|.||.|||::|....|....||..||||.|::...|.
  Fly    83 KLEILRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS 147

  Fly   259 RALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSV---RTLKLSDN 320
            ...:.:.||..|::|.|..|.:..:.|.....||.||.||..|..:...:.:.|   :.||..:.
  Fly   148 STFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNC 212

  Fly   321 WLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSL---PPSLE 382
            .||.||....:..|||..|||..:....::.|....::.|..:.||.|.|..|...|   ..||.
  Fly   213 QLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLN 277

  Fly   383 HLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPP---LSLPKLLTLNLESSGVESV----- 439
            ||.|.:|::.::|..:|:.|.||..||||.|:|:.|.|   .||..|||||:..:.:..:
  Fly   278 HLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRE 342

  Fly   440 -------------SQSIVHTLPQLRDLLLED---------NPIKCSDLLGIA---------EWAS 473
                         |:.....:|||..|.:.|         :|.|....|.|:         |...
  Fly   343 TFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQLRYLNISGNSLNNTALEVID 407

  Fly   474 PCRSVDAGQSNGASVSGRVDLKTEYLQFHNFYENFSSRECGIRKPENDTKPPSCSLTRASATLTT 538
            |||.::.           :||...  |.|...|:...|..|||....|..|..|........:..
  Fly   408 PCRELEF-----------LDLSRN--QLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINV 459

  Fly   539 T---------------PRSMSKVE----------------KSQEAQATATS-------------- 558
            .               |:|:...|                ..:|..|.:||
  Fly   460 VRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAI 524

  Fly   559 ----------VEVAAATAATSEKTGIQAT-----SAAQSTAAATTAEREAIAT---ATSSDTTAT 605
                      |.:.:..|..|:......|     :.::|.......|...|.|   .:|..||.|
  Fly   525 LGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKCLEKNLEATTITTLGNGSSPTTTTT 589

  Fly   606 PTLAAAAAI--------QSAGNIPAQLTT----------KTLRPTETTSLAQLQRRQQMPGMPAK 652
            .|||.:.|.        |.....||..:|          |.:..|...........:.||..|..
  Fly   590 LTLATSPAAPNGPKTNGQGLSLSPANGSTPVHGISDDKGKEINFTFPVDDRVCTIDELMPSPPPP 654

  Fly   653 TTETPAKNLPSL------AQTKATTALPILATRDAATATTEINSDKPTNISGATKT-VATSAAEI 710
            ..:.|..|:.||      :...|||...:      |.|.|.|....|::.|..|.| ....|..:
  Fly   655 PQQHPHPNMGSLMYSVSHSPNSATTLAAV------AAAATVIPPGAPSHSSMPTPTPTPAEAVVV 713

  Fly   711 ATPPAIEVPQ 720
            ..||....||
  Fly   714 VLPPPPLPPQ 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	53/163 (33%)
		leucine-rich repeat	124..143	CDD:275380
		leucine-rich repeat	144..167	CDD:275380
		leucine-rich repeat	172..194	CDD:275380	164/660 (25%)
		LRR_8	193..253	CDD:290566	24/58 (41%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR_8	241..301	CDD:290566	21/59 (36%)
		leucine-rich repeat	243..311	CDD:275380	21/67 (31%)
		leucine-rich repeat	312..335	CDD:275380	7/25 (28%)
		LRR_8	334..415	CDD:290566	30/83 (36%)
		leucine-rich repeat	336..359	CDD:275380	5/22 (23%)
		leucine-rich repeat	360..380	CDD:275380	7/22 (32%)
		LRR_8	379..460	CDD:290566	32/110 (29%)
		LRR_4	379..>415	CDD:289563	16/35 (46%)
		leucine-rich repeat	381..404	CDD:275380	8/22 (36%)
		leucine-rich repeat	405..449	CDD:275380	17/64 (27%)
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..190	CDD:290566	21/58 (36%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_RI	151..422	CDD:238064	77/283 (27%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR_8	178..262	CDD:290566	25/83 (30%)
		leucine-rich repeat	180..203	CDD:275380	8/22 (36%)
		leucine-rich repeat	204..251	CDD:275380	13/46 (28%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	274..334	CDD:290566	26/59 (44%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		LRR_4	298..342	CDD:289563	17/43 (40%)
		leucine-rich repeat	300..323	CDD:275380	11/22 (50%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453582
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930