DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 2mit and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001276671.1	Gene:	Lrrc4c / 241568	MGIID:	2442636	Length:	640	Species:	Mus musculus

Alignment Length:	797	Identity:	179/797 - (22%)
Similarity:	279/797 - (35%)	Gaps:	246/797 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 FNQLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSC-NKFSQ--------------ISTSFFAQ 190
            |:.|..:.|....|.|..|..|.|..|:      .|| |:||:              |||:   .
Mouse    23 FDPLLVVLLALQLLVVAGLVRAQTCPSV------CSCSNQFSKVICVRKNLREVPDGISTN---T 78

  Fly   191 RLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSG 255
            ||     |||..|::..|...||.:|..|:.|.||.|:|..|:...|..|.||..|:|..|||:
Mouse    79 RL-----LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLT- 137

  Fly   256 SAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSDN 320
                   .||:                ..||....||||
Mouse   138 -------TIPN----------------GAFVYLSKLKEL-------------------------- 153

  Fly   321 WLKAINCGDMDSY-----PLLQYLDLSH-SRIAQVEDDALGRLELLESLFLDRNLLMRVPSSLP- 378
            ||:......:.||     |.|:.|||.. .|::.:.:.|...|..|..|.|....|..:|:..|
Mouse   154 WLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPL 218

  Fly   379 PSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPL---SLPKLLTLNLESSGVESVS 440
            ..|:.|.|..|.:..:.|.:|.||::||.|.:..:::..:...   :|..|:.:||..:.:..:.
Mouse   219 IKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLP 283

  Fly   441 QSIVHTLPQLRDLLLEDNPIKCS-DLLGIAEWASPCRSVDAGQSNGA---------SVSGRV--D 493
            ..:...|..|..:.|..||..|: |:|.::.|..     |...||.|         ::.||.  :
Mouse   284 HDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIR-----DMAPSNTACCARCNTPPNLKGRYIGE 343

  Fly   494 LKTEYLQFHNFYENFSSRECGIRKPEND---TKPPSCSL-TRASATLTT----TPRSMSKVEKSQ 550
            |...|         |:.....|.:|..|   |:..:..| .|||.:||:    ||........:.
Mouse   344 LDQNY---------FTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAY 399

  Fly   551 EAQATATSVEVAAATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQ 615
            :.:....|......|..|.:.||:.....:.|.                .:|||:.||...||..
Mouse   400 KVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSV----------------GNTTASATLNVTAATT 448

  Fly   616 SAGNIPAQLTTKTLRPTETTSLAQLQRRQQMPGMPAKTTETPAKNLPSL--AQTKATTALPILAT 678
            :..:..:.:|.:|:.|::.               .|:||:......|.:  ..|..||:|...:|
Mouse   449 TPFSYFSTVTVETMEPSQD---------------EARTTDNNVGPTPVIDWETTNVTTSLTPQST 498

  Fly   679 RDA----ATATTEINSDKPTNISGATKTVATSAAEIATPPAIEVPQTILAGKKSDKMPADKAHET 739
            |..    ....|:|||    .|.|..:.:.|:...|....||    |::|           |...
Mouse   499 RSTEKTFTIPVTDINS----GIPGIDEVMKTTKIIIGCFVAI----TLMA-----------AVML 544

  Fly   740 LLKYPTRDTSGQVATTPHKHATLQLHVKDRHLIGTPLLMHKGDVLLVDAEQLLLPGTATVADADS 804
            ::.|..|.               |.|.::.|   .|                    |.||
Mouse   545 VIFYKMRK---------------QHHRQNHH---AP--------------------TRTV----- 566

  Fly   805 EVLDPSQQHQSAEQEKHQSATDKRQADAINGDTKSPAKGHKKKPSLSIKKMTYSTKHAAKTVEDM 869
            |:::..                    |.|.|||  |.:.|...|::..:.:.:...:  |:..:.
Mouse   567 EIINVD--------------------DEITGDT--PMESHLPMPAIEHEHLNHYNSY--KSPFNH 607

  Fly   870 AATSKTPQHQHSSVNTP 886
            ..|..|....||||:.|
Mouse   608 TTTVNTINSIHSSVHEP 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	62/234 (26%)
		leucine-rich repeat	124..143	CDD:275380	1/1 (100%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..194	CDD:275380	10/36 (28%)
		LRR_8	193..253	CDD:290566	22/59 (37%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR_8	241..301	CDD:290566	15/59 (25%)
		leucine-rich repeat	243..311	CDD:275380	14/67 (21%)
		leucine-rich repeat	312..335	CDD:275380	4/27 (15%)
		LRR_8	334..415	CDD:290566	25/82 (30%)
		leucine-rich repeat	336..359	CDD:275380	7/23 (30%)
		leucine-rich repeat	360..380	CDD:275380	6/20 (30%)
		LRR_8	379..460	CDD:290566	19/83 (23%)
		LRR_4	379..>415	CDD:289563	11/35 (31%)
		leucine-rich repeat	381..404	CDD:275380	8/22 (36%)
		leucine-rich repeat	405..449	CDD:275380	8/46 (17%)
Lrrc4c	NP_001276671.1	LRRNT	47..80	CDD:214470	9/41 (22%)
		PPP1R42	65..235	CDD:411060	59/227 (26%)
		LRR 1	77..98		9/28 (32%)
		leucine-rich repeat	78..101	CDD:275380	10/27 (37%)
		LRR 2	101..122		8/20 (40%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR 3	125..146		10/44 (23%)
		leucine-rich repeat	126..149	CDD:275380	10/46 (22%)
		LRR 4	149..170		8/46 (17%)
		leucine-rich repeat	150..173	CDD:275380	8/48 (17%)
		LRR 5	173..195		6/21 (29%)
		leucine-rich repeat	174..198	CDD:275380	7/23 (30%)
		LRR 6	198..219		6/20 (30%)
		leucine-rich repeat	199..220	CDD:275380	6/20 (30%)
		LRR_8	220..279	CDD:404697	15/58 (26%)
		LRR 7	220..241		6/20 (30%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		LRR 8	244..265		3/20 (15%)
		leucine-rich repeat	245..268	CDD:275380	4/22 (18%)
		LRR_8	267..>301	CDD:404697	6/33 (18%)
		LRR 9	268..289		3/20 (15%)
		leucine-rich repeat	269..290	CDD:275380	3/20 (15%)
		LRRCT	301..>339	CDD:214507	10/42 (24%)
		IG	360..443	CDD:214652	21/98 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..482		5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910