DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 2mit and Lrrc66

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_705796.1	Gene:	Lrrc66 / 231296	MGIID:	2387634	Length:	872	Species:	Mus musculus

Alignment Length:	979	Identity:	182/979 - (18%)
Similarity:	300/979 - (30%)	Gaps:	332/979 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 QRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFL---------------A 239
            |:...:|..:..|:.:..::.:...:|..|:.|.||:..|.....:..|               .
Mouse    75 QKERHIKPPDRTHHRISKVTLDPLAHLHALEILNLSNKAIHYFSLDQPLPPSSHQKRHGGHSHSR 139

  Fly   240 LPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQV 304
            ||.||.|.|..|:|||:.    :|:                        |.||
Mouse   140 LPRLQVLILQRNQLSGTP----KGL------------------------WKLK------------ 164

  Fly   305 PAALAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNL 369
                  |:|:|.||.|  :.::.|..|.:..||
Mouse   165 ------SLRSLDLSFN--RIVHIGLSDFHGCLQ-------------------------------- 189

  Fly   370 LMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESS 434
                       ||.::|:.|:|..:.|:||.||..||.:||.:|.|..|.|     ::|:.||
Mouse   190 -----------LESIYLKSNKICTIHPKAFKGLKKLQVVDLRSNALTTLVP-----IVTIALE-- 236

  Fly   435 GVESVSQSIVHTLPQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDLKTEYL 499
                        ||.| :|.|.||..:||                  :||              :
Mouse   237 ------------LPHL-ELGLADNQWQCS------------------ESN--------------V 256

  Fly   500 QFHNFYENFSSRE-----CGI----RKPENDTKPPSCSLTRASATLTTTPRSM-SKVEKSQEAQA 554
            .|.|...: |.||     |.:    ::|..:|.  ....:|.:..|.:.|..: |.::...|...
Mouse   257 NFQNITSS-SWREIWKAICNMSVENKRPNAETH--QIRKSRDTHLLLSPPSDLKSLIQSKAERPQ 318

  Fly   555 TATSVEVAAATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGN 619
            ....:.::|......:..|.......||......::.|.:   |.......|.|..|..:.....
Mouse   319 AGMDMHLSALGKEAKDGYGDLRGMWPQSPVELRDSQDEQV---TDRKDDKPPALELAICLSVFIT 380

  Fly   620 IPAQLTTKTLRPTETTSLAQLQRRQQMPGMPAKTTETPAKNLPSLAQTKATTALPILATRDAATA 684
            .................|.|.:...:.||     ::....|.......:....:....| |....
Mouse   381 FVVAFCLGAFARPYIDRLRQQRCSNKRPG-----SDNAYSNKGFHGDIEGAQHMEYQGT-DLHQT 439

  Fly   685 TTEINSDKPTNISGATKTVATSAAEIATPPAIEVPQTILAGKKSDKMPADKAHETLLKYPTRDTS 749
            |..::..:..|.|...:.:..||.:                  |::|                 .
Mouse   440 THHLHLSENQNPSWVAEPIPHSAVQ------------------SEQM-----------------L 469

  Fly   750 GQVATTP-HKHATLQLHVKDRHLIGTPLLMHKGDVLLVDAEQLLLPGTATVADADSEVLDPSQQH 813
            |...|.| |:.:..||...:....|..:::..|.|     ..|.|.|... ||| .:.:.|.|.|
Mouse   470 GSNGTDPGHQQSPEQLKDSNESRSGDSIVLPSGPV-----AHLALHGLPN-ADA-HKAISPVQHH 527

  Fly   814 QSAEQEKHQSAT--------DKRQADAINGDTKS-PAKGHKKKPSLSIKKMTYSTKHAAKTVEDM 869
            ....:|.|....        |.....:|.|...: |:....::..|          |.::..:.:
Mouse   528 HDFLEEAHYDTVAQEYSLIDDVMDRSSITGPLGTFPSSVESRRDDL----------HPSQPRDVV 582

  Fly   870 AATSKTPQHQHS--SVNTPKEAAPEELSTF-AQLKAYVELKSESKPEHLMDQR--------EENH 923
            |:.|||..|.::  :..:.:...||.|... :|:.:..|.:..:....|..|:        ||.
Mouse   583 ASFSKTLAHANTREAEGSMETGCPEPLGAMDSQMGSSEERQVSNSIRELATQQPSFQGVDAEER- 646

  Fly   924 HNLTGNHPGVMLLVACVLFIVLLAGLAHVYRCELPWQRSNRSGQLRPHHQRHLNETDDAHSFLHY 988
                                     |:|||...|    .|....|||.....           ||
Mouse   647 -------------------------LSHVYSEVL----HNDPPSLRPRWGSG-----------HY 671

  Fly   989 QGSVNSNGGDPARLQKWHHSTRREAPYSSPLHNLQARELQQQRCQQFYSSSLADKSSSTSSSSSG 1053
               |....|:|         ..|:||: .|.::|...          |.|...:.|..|.||...
Mouse   672 ---VIPATGEP---------VERDAPF-DPHYDLVTN----------YESDSDEGSLFTLSSEGS 713

  Fly  1054 SSRSSLHSPSRDDSYYIEMAPSSPPAANLPSLPMELLGSRSNALGCRTDRVAATDLGGTTEAVPS 1118
            ....||    .::...:|...:|.|      ||...||...:::   |...:..||  |::.:|.
Mouse   714 EDTRSL----AEEQASVENDGTSQP------LPSRNLGEYKDSV---TSAESVEDL--TSQRIPE 763

  Fly  1119 SAAA 1122
            ...|
Mouse   764 KCEA 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	34/179 (19%)
		leucine-rich repeat	124..143	CDD:275380
		leucine-rich repeat	144..167	CDD:275380
		leucine-rich repeat	172..194	CDD:275380	1/3 (33%)
		LRR_8	193..253	CDD:290566	16/74 (22%)
		leucine-rich repeat	195..218	CDD:275380	3/22 (14%)
		leucine-rich repeat	219..242	CDD:275380	7/37 (19%)
		LRR_8	241..301	CDD:290566	13/59 (22%)
		leucine-rich repeat	243..311	CDD:275380	12/67 (18%)
		leucine-rich repeat	312..335	CDD:275380	7/22 (32%)
		LRR_8	334..415	CDD:290566	17/80 (21%)
		leucine-rich repeat	336..359	CDD:275380	2/22 (9%)
		leucine-rich repeat	360..380	CDD:275380	0/19 (0%)
		LRR_8	379..460	CDD:290566	28/80 (35%)
		LRR_4	379..>415	CDD:289563	15/35 (43%)
		leucine-rich repeat	381..404	CDD:275380	10/22 (45%)
		leucine-rich repeat	405..449	CDD:275380	12/43 (28%)
Lrrc66	NP_705796.1	LRR	<95..326	CDD:227223	76/376 (20%)
		leucine-rich repeat	104..142	CDD:275380	7/37 (19%)
		LRR 1	142..164		10/49 (20%)
		leucine-rich repeat	143..165	CDD:275380	12/67 (18%)
		LRR_8	165..224	CDD:338972	25/103 (24%)
		LRR 2	165..186		8/22 (36%)
		leucine-rich repeat	166..189	CDD:275380	7/24 (29%)
		LRR 3	189..210		9/63 (14%)
		leucine-rich repeat	190..213	CDD:275380	10/22 (45%)
		LRR 4	213..234		9/25 (36%)
		LRR 5	239..259		9/52 (17%)
		leucine-rich repeat	240..263	CDD:275380	11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..363		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..501		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..579		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..761		19/90 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100