DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 2mit and ECM2

DIOPT Version :9

Sequence 1:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001384.1	Gene:	ECM2 / 1842	HGNCID:	3154	Length:	699	Species:	Homo sapiens

Alignment Length:	347	Identity:	91/347 - (26%)
Similarity:	141/347 - (40%)	Gaps:	90/347 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 ELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAM 282
            ::.:|.|:.|:|:.|..|.|..||||:.||||.|.::.|                      |:..
Human   344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSS----------------------GIGP 386

  Fly   283 QEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRI- 346
            :.|.....|..|:..|..|.|:|:.|..::..||:::|.|:||:...:.....|..|:|..:.:
Human   387 KAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451

  Fly   347 -AQVEDDALGRLELLESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIME----------------- 393
             |.|...|...|:.|..|.|.:|....:|..||.|:|.|:|::|||.|
Human   452 EANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVL 516

  Fly   394 ---------LPPQAFVGLVNLQTLDLSNNRLIFLPPLSLPK-LLTLNLESSGVESVSQSIV-HTL 447
                     :.|.|::...||:::|||.|:|..:|.. ||| ||.|.|..:.:|.:...:. |..
Human   517 RYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSY-LPKSLLHLVLLGNQIERIPGYVFGHME 580

  Fly   448 PQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDLKTEYLQFHNFYENFSSRE 512
            |.|..|.|..|.:                 .|.|          :|..:.|..:|:..|.|..
Human   581 PGLEYLYLSFNKL-----------------ADDG----------MDRVSFYGAYHSLRELFLD-- 616

  Fly   513 CGIRKPENDTK--PPSCSLTRA 532
                  .||.|  ||.....:|
Human   617 ------HNDLKSIPPGIQEMKA 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	38/138 (28%)
		leucine-rich repeat	124..143	CDD:275380
		leucine-rich repeat	144..167	CDD:275380
		leucine-rich repeat	172..194	CDD:275380
		LRR_8	193..253	CDD:290566	16/34 (47%)
		leucine-rich repeat	195..218	CDD:275380	91/347 (26%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR_8	241..301	CDD:290566	14/59 (24%)
		leucine-rich repeat	243..311	CDD:275380	16/67 (24%)
		leucine-rich repeat	312..335	CDD:275380	6/22 (27%)
		LRR_8	334..415	CDD:290566	30/108 (28%)
		leucine-rich repeat	336..359	CDD:275380	7/24 (29%)
		leucine-rich repeat	360..380	CDD:275380	7/19 (37%)
		LRR_8	379..460	CDD:290566	32/108 (30%)
		LRR_4	379..>415	CDD:289563	16/61 (26%)
		leucine-rich repeat	381..404	CDD:275380	9/48 (19%)
		leucine-rich repeat	405..449	CDD:275380	16/45 (36%)
ECM2	NP_001384.1	VWC	103..157	CDD:278520
		Amnionless	<116..>213	CDD:317263
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..316
		Cell attachment site. /evidence=ECO:0000255	294..296
		NEL	<320..>572	CDD:330839	72/250 (29%)
		leucine-rich repeat	321..344	CDD:275380	91/347 (26%)
		leucine-rich repeat	345..368	CDD:275380	8/22 (36%)
		LRR 1	368..388		9/41 (22%)
		leucine-rich repeat	369..394	CDD:275380	9/46 (20%)
		LRR 2	394..415		7/20 (35%)
		leucine-rich repeat	395..415	CDD:275380	7/19 (37%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		LRR 3	416..436		6/19 (32%)
		LRR 4	439..459		5/19 (26%)
		leucine-rich repeat	440..465	CDD:275380	7/24 (29%)
		LRR 5	465..484		5/18 (28%)
		leucine-rich repeat	466..486	CDD:275380	7/19 (37%)
		LRR 6	486..507		8/20 (40%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		LRR	491..>673	CDD:227223	42/178 (24%)
		LRR 7	510..530		1/19 (5%)
		leucine-rich repeat	511..536	CDD:275380	2/24 (8%)
		LRR 8	536..557		10/21 (48%)
		LRR 9	558..578		5/19 (26%)
		LRR 10	582..602		7/46 (15%)
		leucine-rich repeat	583..606	CDD:275380	8/49 (16%)
		LRR 11	609..630		7/28 (25%)
		leucine-rich repeat	610..632	CDD:275380	7/29 (24%)
		LRR 12	632..653		1/1 (100%)
		leucine-rich repeat	633..653	CDD:275380	91/347 (26%)
		LRR 13	661..684
		leucine-rich repeat	662..687	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40317
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000