DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment timeout and TIMELESS

DIOPT Version :9

Sequence 1:	NP_524341.3	Gene:	timeout / 41615	FlyBaseID:	FBgn0038118	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_003911.2	Gene:	TIMELESS / 8914	HGNCID:	11813	Length:	1208	Species:	Homo sapiens

Alignment Length:	1254	Identity:	432/1254 - (34%)
Similarity:	701/1254 - (55%)	Gaps:	97/1254 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSILLADIDATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVY 65
            :.::..::.|||:||||.:|..|..|||..|.:|.||..||.:.:..:.|:.||.:::||:||:.
Human     3 LHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLP 67

  Fly    66 MLPDYVHHEE--LSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKV 128
            :|..  ||::  |.|.:|||:|.||.|.||.: ...||:...|..|::::..||.||.|||.:|.
Human    68 ILTQ--HHQDKPLFDAVIRLMVNLTQPALLCF-GNLPKEPSFRHHFLQVLTYLQAYKEAFASEKA 129

  Fly   129 WSALFEKLKQALEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALH 193
            :..|.|.|.:.|::.:..|.||.||||||||:||||:|.|||:.:.|.:.|:|||.|||::||:|
Human   130 FGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKIDDDASAHDQLLWAIH 194

  Fly   194 QTGMLDLVLFVISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRR 258
            .:|:.||:||:.||..|||:.||.||||.|:||:|:.|.||.....|...|:..|..||...|:|
Human   195 LSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQR 259

  Fly   259 ERARRQAR--PPPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFDREKQQQK-RSHRHI 320
            |.|.::.|  ....|||||||:|:::.:||:.:||:|.|:.|..:.:...|..||.:| ...|..
Human   260 EMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQA 324

  Fly   321 QEEAQVTRRSAFTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEF 385
            ..|..:.||||..|||.||::|.|.|.:.||.|:..|:..|.|.. :..||::|.:||:.|||.|
Human   325 ARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREK-AQQHDETYYMWALAFFMAF 388

  Fly   386 NRLSGLQLQLVSESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLAL 450
            ||.:..:..||||:|||:.||::...:.:..:|:::|:|:|..||:|:|:||..::|||.::..:
Human   389 NRAASFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEM 453

  Fly   451 QKLKDDNNARALFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFC 515
            . :..|...|....::.||:.||:||||..|.|...::|....:.||||:|||.::|:||:||||
Human   454 D-ISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLERFC 517

  Fly   516 QD--SVVVQDKKRGRGASRKK--KQAATKSKPPAAPQPTEEELSSKWAELATEV-CSLLSTELEM 575
            :.  ::|||:|::.|...:||  .||......|::|    ||:.:.|..||.:: |...::||.|
Human   518 RSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSP----EEVEAVWPALAEQLQCCAQNSELSM 578

  Fly   576 PEDEQPLPFDAASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPE 640
               :..:|||||||..:::||.:.|:||...|.:.:..||:.|||:|||||||.:|||:...:||
Human   579 ---DSVVPFDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGDVFGSQDISPE 640

  Fly   641 DELLLLREIFMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARR 705
            :|:.||::|..:.:...:..::...::::::|.|:|:        |.|...::||.|.|.|:.:|
Human   641 EEIQLLKQILSAPLPRQQGPEERGAEEEEEEEEEEEE--------ELQVVQVSEKEFNFLDYLKR 697

  Fly   706 LLNPKIVRACTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVH 770
            .....:|||..|:|..:......:....|.:|||:|:..|...:|||..:|.:|.::.|......
Human   698 FACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGA 762

  Fly   771 QEELRRLAIFVVRKFVEVAPTNPKIYAELLFYKGIREANELESGY---CDAYEAGTKGAWTEEQE 832
            .:||...|.:::.||..:|..|.|.:.||||:|......|:..||   .|...:.....|:.|:|
Human   763 YKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEE 827

  Fly   833 SELRFLFEENQRNPETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQ-SGK 896
            :.||.|:..|:  ....:||::.||.:|....|.|:.::..|.::||      ..|.|..| .|.
Human   828 AHLRELYLANK--DVEGQDVVEAILAHLNTVPRTRKQIIHHLVQMGL------ADSVKDFQRKGT 884

  Fly   897 NV--WQPEEDDELRSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADK--------- 950
            ::  |..:::.||:.|:::.|...|.|..::.....:||:.:|:.::|.:.|:|::
Human   885 HIVLWTGDQELELQRLFEEFRDSDDVLGHIMKNITAKRSRARIVDKLLALGLVAERRELYKKRQK 949

  Fly   951 ---SEILPAKKGRGKDKPKKDVEMEGEGDEFDFAEEPMFEDQGYKKPKSKPKKVQKRQMVRTPLD 1012
               |.|||......||..::|:|.|....|.|..||   |:.|     |:.::|| ..:|.:..:
Human   950 KLASSILPNGAESLKDFCQEDLEEEENLPEEDSEEE---EEGG-----SEAEQVQ-GSLVLSNEN 1005

  Fly  1013 VGTIRALIGQVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQKNAMEDGD 1073
            :|.      .:..|.:...:.|||.||..|::|.||     ||    |||:||.|..:.|||:..
Human  1006 LGQ------SLHQEGFSIPLLWLQNCLIRAADDREE-----DGCSQAVPLVPLTEENEEAMENEQ 1059

  Fly  1074 FQKVLVALGMQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDEDGEEAEESD 1138
            ||::|..||::||.||.|.:||||..|:...|...:..|:..|.:.:.:.|......||:.  ||
Human  1060 FQQLLRKLGVRPPASGQETFWRIPAKLSPTQLRRAAASLSQPEEEQKLQPELQPKVPGEQG--SD 1122

  Fly  1139 EEEDFLEKHSRQRKENIATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASEKKAKRKVKGKAK 1203
            ||.  .::|..|....:....::|..  :.:..:::...:.|.||..|        ||::....:
Human  1123 EEH--CKEHRAQALRALLLAHKKKAG--LASPEEEDAVGKEPLKAAPK--------KRQLLDSDE 1175

  Fly  1204 ESKDCNDDGTDKA-ELEKP 1221
            |.::  |:|.::| ||..|
Human  1176 EQEE--DEGRNRAPELGAP 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	118/261 (45%)
timeout	NP_524341.3	TIMELESS_C	736..1217	CDD:252956	141/503 (28%)
TIMELESS	NP_003911.2	Required for homodimerization and for interaction with CRY1 and CHEK1. /evidence=ECO:0000250\|UniProtKB:Q9R1X4	1..309		133/308 (43%)
		TIMELESS	25..284	CDD:282651	118/261 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..679		3/31 (10%)
		TIMELESS_C	728..1200	CDD:252956	144/509 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..994		9/30 (30%)
		Interaction with PARP1. /evidence=ECO:0000269\|PubMed:26344098	1000..1098		39/108 (36%)
		Required for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q9R1X4	1082..1208		29/127 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1131		11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1143..1208		14/62 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1630
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31206
Inparanoid	1	1.050	670	1.000	Inparanoid score	I743
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49276
OrthoDB	1	1.010	-	-		D191401at33208
OrthoFinder	1	1.000	-	-		FOG0004685
OrthoInspector	1	1.000	-	-		oto90917
orthoMCL	1	0.900	-	-		OOG6_102693
Panther	1	1.100	-	-	LDO	PTHR22940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1424
SonicParanoid	1	1.000	-	-		X5023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870