DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment timeout and TOF1

DIOPT Version :9

Sequence 1:	NP_524341.3	Gene:	timeout / 41615	FlyBaseID:	FBgn0038118	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_014126.1	Gene:	TOF1 / 855448	SGDID:	S000005217	Length:	1238	Species:	Saccharomyces cerevisiae

Alignment Length:	1573	Identity:	278/1573 - (17%)
Similarity:	529/1573 - (33%)	Gaps:	562/1573 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSILLADIDATCAALG---YS---DGQKYQAEPDAAEGLKHL-IWILRRDLDNHEYRRHLGRS-- 56
            :::|.|.|.....|:|   |:   |...|:...|....||.| .|.  :.:|:.:.|..:..:
Yeast    17 LTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKRWF--KLVDDQQKRWDVAMAVA 79

  Fly    57 --KVLQTDLVYMLPDYVH--------------HEELSDL---------LIRLLVILTNPTLLLYR 96
              ::|..||:.:|.|:.:              |||..:.         .::|||::|.|.::..:
Yeast    80 EYRILTDDLLPILIDWENKCSLAAKLAKNNPDHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQ 144

  Fly    97 EGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQALEIAFAI-------RSEEQNLL 154
            ..:.:        :.|...|:.::..:.|..:.....:.|:.|:.:|..:       |:...|::
Yeast   145 SSSNQ--------ITLYGELKKHQLVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMV 201

  Fly   155 IERILVLVRNVLQV------------------------PANPEAECRADNDASLHDQVIWALHQT 195
            ::.:|...|||:.:                        |.|...:     |.|| :.||.:.|:.
Yeast   202 LKLVLNFFRNVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMD-----DISL-NTVISSFHKN 260

  Fly   196 GMLDLVLFVISSP----DEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAAR 256
            .:...:|.:.||.    |::..::..|||:....::.:.|.|.....:.....|..::.|..:|.
Yeast   261 KVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRQFETGTHSKVVNKNESSSAN 325

  Fly   257 --------------RRERARRQ--ARPPPGRHSRFGGTYVIRNMKSVSDRD-----VICHQAL-- 298
                          ::|...|:  .:....|||||||      :.|:...|     |...|||
Yeast   326 NIVTSAGFELSKLLQKEHQMRKNVIKHTSARHSRFGG------LLSIQTPDKTRLTVSGSQALVD 384

  Fly   299 ERVSSIDFDREKQQQKR---SHRHIQEE--------AQVTRRSAFTVR--LCLREYCIEVLRSAY 350
            |:::....|..|:..||   .|:.:..|        :|..:...||..  ...:|:....:.|.:
Yeast   385 EKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGF 449

  Fly   351 NTLVRQVRR--VLERNAGSSSHDDSYLL---WAIRFFMEFNRL-SGLQLQLVSESLSVQCFHWV- 408
            |.|:..|..  ..|::...:.....|||   |.:::.:..::: :...::.|||:|....|..|
Yeast   450 NILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEVTFILVS 514

  Fly   409 -LTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKLKDDNNARALFDMLLNNVCY 472
             |.|..:|:          :.|.. .|..::.|.||| :|::..|...:.::..: :.:::.:
Yeast   515 SLLRSAYDL----------KNWTV-THAGMIAFNELL-NLVSRTKAAQEEDSTDI-EFIVSRL-- 564

  Fly   473 VLEYRETVLHLLMNYNEAHS--TKVFLRDVVETANVFIKMMERFCQDSVVVQDKKRGRGASRKKK 535
               :.:..:.||.|..:..|  :..|::..:|..:..:|::|::..|..:|.:     |.||::|
Yeast   565 ---FSDERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSDDKTLVIE-----GKSRRQK 621

  Fly   536 QAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPFDAASEKSIDDQREDCM 600
                                                :..:.|.:
Yeast   622 ------------------------------------KFNISEGD--------------------- 629

  Fly   601 IRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLLREIFMSNITTVESEDKENE 665
              |.||:..|.:|:                          ||.|   :|..|::.::|...:
Yeast   630 --ITKLIEEENVDR--------------------------DEAL---DILTSSLRSIEVNFQ--- 660

  Fly   666 KDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFK-FDDFARRLLNPKIVRACTLVLSDWADIPTRS 729
                                :.|.|.:||...: :.:|..|                :.::...|
Yeast   661 --------------------KVQANYMTEPVIETYINFLER----------------FRELEDDS 689

  Fly   730 LKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEELRRLA-----IFVVR--KFVE 787
            :|...:..||:....|...:||:..|..:.:::.|.:........|:..     .|:.|  |.::
Yeast   690 IKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRKYVSQFSDYFLARLKKRLK 754

  Fly   788 VAPT-------NPKIYAELLFYKGIREANELESGYCDAYEAGTKGAWTEEQESELRFLFEENQRN 845
            .:|.       .|...:|:.||:...|.|.|                    .:|..:....:|..
Yeast   755 KSPAWFVGLLFPPLHNSEVGFYQRYGEYNVL--------------------NNESMYAAPASQFK 799

  Fly   846 PETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKNVWQPEEDDELRSL 910
            |..|::.:.             .::|..:| .|:|                          :.:|
Yeast   800 PIPDEEALP-------------PSILLDMK-YGVL--------------------------VSTL 824

  Fly   911 YDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGKDKPKKDVEMEGEG 975
            .|..:.|  .|::|:.....   ...|.|..|.:::.|.|..:.|         |.:...:.|.
Yeast   825 LDDGKTE--LLDQLLKHITH---TLDIFKSWLTVNVNAGKETVNP---------PNEYFTLTGV- 874

  Fly   976 DEFDFAEEPMFEDQGYKK-----PKSKPKKVQKRQMVRTPLDVGTIRALIGQVDSEKYQSAIEWL 1035
                ...:|:|:|:.|:.     ..|.|:|:.:...:...::|..:......|  :||.|.
Yeast   875 ----LNNDPIFKDKDYRALLLLIGYSIPRKINEPCFLPGTVEVSDLTVSCELV--KKYLST---- 929

  Fly  1036 QECLQDASEDTEEAVEDDDGVPLLPLMENQKNAMEDGDFQKVLVALGMQPPISGMEAYWRIPIYL 1100
                         ..|..:|:|
Yeast   930 -------------PFETPNGLP------------------------------------------- 938

  Fly  1101 NSADLILRSKILAGEEVDAEPEDEAADDEDGEEAEESDEEEDFLEKHSRQRKENIATQQQ--RKL 1163
             |:..:||        |.:|.:..:.:::||   .|.|::.|:.:.:       |....|  .|.
Yeast   939 -SSSYLLR--------VRSEKDSFSHNEQDG---WEGDDDYDYNDPY-------IVPDDQILSKS 984

  Fly  1164 DSLMFNQSDDETEQRAPPKAKDKPKA---------SEKKAKRK-VKGKAKESKDCNDDGTDKAEL 1218
            |:..|...|:        .|.||.|.         |:||.||| .||:||.:.....|..|
Yeast   985 DAAYFKDLDN--------NASDKLKGTKFSKGIARSKKKDKRKRRKGEAKTNLPMFGDQDD---- 1037

  Fly  1219 EKPNTDDLFNQLRAKRA--TKIKLSDMALNESTNAAQEADDDAFN---FNSEDYRARLLELEDEE 1278
            |:|.|      :|.:..  :|..:||          .|.|:|..|   |.:|.|...||:..:.:
Yeast  1038 ERPQT------VRERHGVFSKEFISD----------SEDDEDLMNPIFFENETYMRWLLDKNNGQ 1086

  Fly  1279 -------QNSKDADE---NG----GDKENITNKSLQRARRVNVIDSDSDNDDDGAL--------- 1320
                   |.:|.|.|   ||    ||..::...|:.....:...:|.|...|...:
Yeast  1087 LTEDRYIQFAKFAAERMNNGGVVTGDYTSLFGGSIPSIESIRATESSSFAPDKSLISLASHVASE 1151

  Fly  1321 ----PADKTNKRPRSDDDGDSGHMDANAEEDSDEEANFLARKKPAKVDG----------EPAKRR 1371
                ..:..|....||||.:|            |..|.|...:|:....          |..||.
Yeast  1152 MSIFDVNNNNNNQLSDDDVNS------------ESRNSLGSSQPSNSQNMFQSEVYSRKESTKRS 1204

  Fly  1372 -RLAIIDDDDEDD 1383
             ..:..|:.|||:
Yeast  1205 LEASAADESDEDE 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	62/336 (18%)
timeout	NP_524341.3	TIMELESS_C	736..1217	CDD:252956	87/511 (17%)
TOF1	NP_014126.1	TIMELESS	45..366	CDD:398476	62/342 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004685
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102693
Panther	1	1.100	-	-	LDO	PTHR22940
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1424
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860