| Sequence 1: | NP_524341.3 | Gene: | timeout / 41615 | FlyBaseID: | FBgn0038118 | Length: | 1384 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_112630.2 | Gene: | Timeless / 83508 | RGDID: | 620939 | Length: | 1205 | Species: | Rattus norvegicus |
| Alignment Length: | 1230 | Identity: | 425/1230 - (34%) |
|---|---|---|---|
| Similarity: | 683/1230 - (55%) | Gaps: | 90/1230 - (7%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 10 ATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHE 74
Fly 75 ELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQA 139
Fly 140 LEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFV 204
Fly 205 ISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQAR--P 267
Fly 268 PPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFDREKQQQK-RSHRHIQEEAQVTRRSA 331
Fly 332 FTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRLSGLQLQLV 396
Fly 397 SESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKLKDDNNARA 461
Fly 462 LFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFCQD--SVVVQDK 524
Fly 525 KRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPFDAASE 589
Fly 590 KSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLLREIFMSNI 654
Fly 655 TTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNPKIVRACTLVL 719
Fly 720 SDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEELRRLAIFVVRK 784
Fly 785 FVEVAPTNPKIYAELLFYKGIREANELESGYCDAYEAGT----KGAWTEEQESELRFLFEENQRN 845
Fly 846 PETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQ-SGKNV--WQPEEDDEL 907
Fly 908 RSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGKDKPKKDVEME 972
Fly 973 GEGDEFD-FAEEPMFEDQGYKKPKSKPKKVQKRQMVRTPLDVGTIRALIGQVDSEKYQSA----- 1031
Fly 1032 ----------IEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQKNAMEDGDFQKVLVALG 1082
Fly 1083 MQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDEDGEEAEESDEEEDFLEKH 1147
Fly 1148 SRQRKENIATQQQRKLDSLMF--NQSDDETEQRAPPKAKDKPKASEKKAKRKVKGKAKES 1205 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| timeout | NP_524341.3 | TIMELESS | 23..281 | CDD:282651 | 119/259 (46%) |
| TIMELESS_C | 736..1217 | CDD:252956 | 135/499 (27%) | ||
| Timeless | NP_112630.2 | Required for homodimerization and for interaction with CRY1 and CHEK1. /evidence=ECO:0000250|UniProtKB:Q9R1X4 | 1..309 | 135/297 (45%) | |
| TIMELESS | 25..284 | CDD:398476 | 119/259 (46%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 651..676 | 6/28 (21%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 942..997 | 18/69 (26%) | |||
| Interaction with PARP1. /evidence=ECO:0000250|UniProtKB:Q9UNS1 | 999..1097 | 37/103 (36%) | |||
| TIMELESS_C | 1005..1091 | CDD:398621 | 34/91 (37%) | ||
| Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q9R1X4 | 1081..1205 | 27/112 (24%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1092..1205 | 22/100 (22%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C166354364 | |
| Domainoid | 1 | 1.000 | 274 | 1.000 | Domainoid score | I1710 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1974 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 1 | 1.000 | - | - | H31206 | |
| Inparanoid | 1 | 1.050 | 650 | 1.000 | Inparanoid score | I759 |
| OMA | 1 | 1.010 | - | - | QHG49276 | |
| OrthoDB | 1 | 1.010 | - | - | D191401at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0004685 | |
| OrthoInspector | 1 | 1.000 | - | - | oto98012 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_102693 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR22940 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X5023 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 15 | 14.770 | |||||