DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment timeout and tim

DIOPT Version :9

Sequence 1:	NP_524341.3	Gene:	timeout / 41615	FlyBaseID:	FBgn0038118	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_001334730.1	Gene:	tim / 33571	FlyBaseID:	FBgn0014396	Length:	1421	Species:	Drosophila melanogaster

Alignment Length:	1706	Identity:	277/1706 - (16%)
Similarity:	507/1706 - (29%)	Gaps:	693/1706 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSILLA--DIDATCAALGYSDGQKYQAEPDAAEGLKHLIWILR-RDLDNHEYRRHLGRSKVLQTD 62
            |..|||  .:.:..::||..:|..|...|:|...|:.:.:.|. .|.....:||.:|..:.:::|
  Fly    24 MDWLLATPQLYSAFSSLGCLEGDTYVVNPNALAILEEINYKLTYEDQTLRTFRRAIGFGQNVRSD 88

  Fly    63 LVYMLPDYVHHEELSDLLIRLLVILTNPTLLLYR-EGAPKDNHGRKVFMELIDILQGYKAAFAKD 126
            |:.:| :....:.:.:.:||:||.||.|...|:. :...:.:.||....||..:|...|.||.:.
  Fly    89 LIPLL-ENAKDDAVLESVIRILVNLTVPVECLFSVDVMYRTDVGRHTIFELNKLLYTSKEAFTEA 152

  Fly   127 KVWSALFEKLKQALEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAEC------RADNDASLH 185
            :...::.|.:|..||....: |..:...|...|:|:||:|.:| ...|.|      ...:..|:.
  Fly   153 RSTKSVVEYMKHILESDPKL-SPHKCDQINNCLLLLRNILHIP-ETHAHCVMPMMQSMPHGISMQ 215

  Fly   186 DQVIWALHQTGMLDLVLFVISSPDEEQFHLHGLEIVCLLFREQ---SAESLADASLQRSLSEKQR 247
            :.::|.|....:..|:|::::.|....:.:..::::.|::::|   :.:.|.....:.||||...
  Fly   216 NTILWNLFIQSIDKLLLYLMTCPQRAFWGVTMVQLIALIYKDQHVSTLQKLLSLWFEASLSESSE 280

  Fly   248 DQQ----------------------------------------ELLAARRRERARR-------QA 265
            |.:                                        |..||..:|.:|:       .|
  Fly   281 DNESNTSPPKQGSGDSSPMLTSDPTSDSSDNGSNGRGMGGGMREGTAATLQEVSRKGQEYQNAMA 345

  Fly   266 RPP----------------------------PGRHSRFGGTYVIRNMKSVS-------DRDVI-- 293
            |.|                            |...|...|.|..:..:.::       |.|.:
  Fly   346 RVPADKPDGSEEASDMTGNDSEQPGSPEQSQPAGESMDDGDYEDQRHRQLNEHGEEDEDEDEVEE 410

  Fly   294 ----------------------------------------------------------------- 293

  Fly   411 EEYLQLGPASEPLNLTQQPADKVNNTTNPTSSAPQGCLGNEPFKPPPPLPVRASTSAHAQMQKFN 475

  Fly   294 ------------------------------CHQA---------------------LERVSSIDFD 307
                                          |.|.                     .|.:|:...|
  Fly   476 ESSYASHVSAVKLGQKSPHAGQLQLTKGKCCPQKRECPSSQSELSDCGYGTQVENQESISTSSND 540

  Fly   308 REKQQQKRSH----------------------RHIQEEAQVTRRSAFTVRL-------------- 336
            .:..|.|..|                      :.::.:..|.|..:..:.:
  Fly   541 DDGPQGKPQHQKPPCNTKPRNKPRTIMSPMDKKELRRKKLVKRSKSSLINMKGLVQHTPTDDDIS 605

  Fly   337 -CLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRLSGLQLQLVSESL 400
             .|:|:.::.|...|:.||.::...|..|| ....|.|:..|.:.:|::|    ..||:|..|.:
  Fly   606 NLLKEFTVDFLLKGYSYLVEELHMQLLSNA-KVPIDTSHFFWLVTYFLKF----AAQLELDMEHI 665

  Fly   401 SVQCFHWVLTRMQHD----MDMIVSDKKQ----ARLWAKRLHVALLTFRELLQSLLALQK---LK 454
            .....:.||:.:.::    .:.:..:.:|    .:.:.:|:|:.:...||.||::....|   |.
  Fly   666 DTILTYDVLSYLTYEGVSLCEQLELNARQEGSDLKPYLRRMHLVVTAIREFLQAIDTYNKVTHLN 730

  Fly   455 DDNNARALFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFCQDSV 519
            :|:.|.  ...|...:..:.:.|...:.||..:|.:..:|.:|:|:|.|.::.:.:::.
  Fly   731 EDDKAH--LRQLQLQISEMSDLRCLFVLLLRRFNPSIHSKQYLQDLVVTNHILLLILDS------ 787

  Fly   520 VVQDKKRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPF 584
                                               |:|.....|
  Fly   788 -----------------------------------SAKLGGCQT--------------------- 796

  Fly   585 DAASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLLREI 649
                            ||:     ||.:.|...|     ||.   ..:|          :||
  Fly   797 ----------------IRL-----SEHITQFATL-----EVM---HYYG----------ILL--- 819

  Fly   650 FMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNPKIVRA 714
                                        :|.:|                         |.:.|..
  Fly   820 ----------------------------EDFNN-------------------------NGEFVND 831

  Fly   715 CTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEELRRLAI 779
            |..                 |::|.|.......|:|||..:.:.:.:::..:.:: .::...|..
  Fly   832 CIF-----------------TMMHHIGGDLGQIGVLFQPIILKTYSRIWEADYEL-CDDWSDLIE 878

  Fly   780 FVVRKFVEVAPTNPKIYAELLFYKGIREANELESGYCDAYEAGTKGAWTEEQESELRFLFEENQR 844
            :|:.||:...|.:|.........:..:|.|: |...|         :|::|:...|.:.:.::::
  Fly   879 YVIHKFMNTPPKSPLTIPTTSLTEMTKEHNQ-EHTVC---------SWSQEEMDTLYWYYVQSKK 933

  Fly   845 NPETDKDVIDWIL---DNLVDKTRNRRTVLKKLKELGL--------------------LFKAPTK 886
            |    .|::..|:   .|..:|.:.|.:::::|.:..:                    |...||.
  Fly   934 N----NDIVGKIVKLFSNNGNKLKTRISIIQQLLQQDIITLLEYDDLMKFEDAEYQRTLLTTPTS 994

  Fly   887 RSTKSAQSGKNVWQPEEDDELRSLYD--------QHRIEPDCLERLVNEFAERRSKQQIIKRMLQ 943
            .:|:|....|.....:..|:::.|.|        ||.:   .|:|::.|..       .:|..|:
  Fly   995 ATTESGIEIKECAYGKPSDDVQILLDLIIKENKAQHLL---WLQRILIECC-------FVKLTLR 1049

  Fly   944 IHLIADKSEILPAKKGRGKDKPKKDVEMEGEGDEFDFAEEPMFEDQGYK---KPKSKPKKVQKRQ 1005
                            .|...|        |||.       :.|...|.   |.||.|
  Fly  1050 ----------------SGLKVP--------EGDH-------IMEPVAYHCICKQKSIP------- 1076

  Fly  1006 MVRTPLDVGTIRALIGQVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDGVPLLPLMENQKNAME 1070
                                     .::|..|                           |...|.
  Fly  1077 -------------------------VVQWNNE---------------------------QSTTML 1089

  Fly  1071 DGDFQKVLVALGMQPPISGMEAYWRIPIYLNSADLI-----------LRSKILAGEEVDAEPEDE 1124
            ...|..:|..||:|.|......:.|||.|.....:.           |..|..|.|..||.....
  Fly  1090 YQPFVLLLHKLGIQLPADAGSIFARIPDYWTPETMYGLAKKLGPLDKLNLKFDASELEDATASSP 1154

  Fly  1125 A------------------ADDEDGEEAEESDEEEDFLEK-HSR----QRKENIATQQQRKLDSL 1166
            :                  .|..|.||.....|.:..:|| |:.    ...|..|..:.:..:|:
  Fly  1155 SRYHHTGPRNSLSSVSSLDVDLGDTEELALIPEVDAAVEKAHAMASTPSPSEIFAVPKTKHCNSI 1219

  Fly  1167 MFNQSDDETEQRAPPKAKDKPKASEKKAKRKVKGKAKESKDC--------NDDGTDKA------- 1216
            : ..:.|.|    ||...........|...:. |.:.:..||        :|:|..|:
  Fly  1220 I-RYTPDPT----PPVPNWLQLVMRSKCNHRT-GPSGDPSDCIGSSSTTVDDEGFGKSISAATSQ 1278

  Fly  1217 ------ELEKPNTDDLFNQLRAKR-------------ATKIKLSDMALNESTNAA--------QE 1254
                  ....|.|....|.|....             .|...||.:|| .||.||        .|
  Fly  1279 AASTSMSTVNPTTTLSLNMLNTFMGSHNENSSSSGCGGTVSSLSMVAL-MSTGAAGGGGNTSGLE 1342

  Fly  1255 ADDDAFNFNSEDYRARLLELEDEEQNSKDADENGGDKENITNKSLQRARRVNVIDSDSD-NDDDG 1318
            .|.||...:|.:   ||     |...|..:..|..|:|       ..|...:|.:.:.: |.|:.
  Fly  1343 MDVDASMKSSFE---RL-----EVNGSHFSRANNLDQE-------YSAMVASVYEKEKELNSDNV 1392

  Fly  1319 ALPADKTNKRPRSDDD 1334
            :|.:|.|......:||
  Fly  1393 SLASDLTRMYVSDEDD 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	68/343 (20%)
timeout	NP_524341.3	TIMELESS_C	736..1217	CDD:252956	95/569 (17%)
tim	NP_001334730.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1974
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22940
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930