DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment timeout and timeless

DIOPT Version :9

Sequence 1:	NP_524341.3	Gene:	timeout / 41615	FlyBaseID:	FBgn0038118	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_001265529.1	Gene:	timeless / 325855	ZFINID:	ZDB-GENE-030131-8978	Length:	1278	Species:	Danio rerio

Alignment Length:	1427	Identity:	459/1427 - (32%)
Similarity:	735/1427 - (51%)	Gaps:	214/1427 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHE 74
            |||:||||.:|..|..|||..|.:|.||..||.:.|..:.|:.||..::||.||:.::..:...:
Zfish    12 ATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDK 76

  Fly    75 ELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQA 139
            .|.|..|||:|.||.|.||.:.: .|.|...|..|:::...||.||.|||.:||::.|.|.|...
Zfish    77 PLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNL 140

  Fly   140 LEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFV 204
            |::.:..|.||.||||||||:||||||.|||:|..|...|:|||:||:::||:|.:|:.||:.|:
Zfish   141 LQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFL 205

  Fly   205 ISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQARP-- 267
            ..:..|:|:..|.|||:.|:||:|:||.|..|...||..|||:|.|||...|::|.|.:::|.
Zfish   206 ACAQSEQQWSFHILEIISLMFRDQTAELLVSAGQMRSAQEKQKDMQELELLRQKETAEKRSRTLM 270

  Fly   268 PPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFD---------REKQQQKRSHRHIQEE 323
            ...|||||.|:|||..:||:.:.||:.||.|....|...|         :.||..|.|..|
Zfish   271 RGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSH---- 331

  Fly   324 AQVTRRSAFTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRL 388
                ||||..|||.|||:||:.|.:.||.|:..|:..|.|.. :..||::|.:||:.|||.||||
Zfish   332 ----RRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRER-AQQHDETYYMWALTFFMAFNRL 391

  Fly   389 SGLQLQLVSESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKL 453
            ...:..:|||::|::.||::...:.:..:|:::||..|..|::|:|:||..::|||.::..:.:.
Zfish   392 QNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRS 456

  Fly   454 KDDNNARALFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFC--Q 516
            ||: |.|....::.:|:.|::|:||..|.||..|:|....:.||||:||:|::|::|:||||  :
Zfish   457 KDE-NIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLERFCKGR 520

  Fly   517 DSVVVQDKKRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPED--E 579
            :::|||.|:    ..|||:   ::.||..  :.:.|:|...|..::.|   |.::..::||.  |
Zfish   521 NNLVVQKKR----VKRKKR---SQKKPEM--ETSAEDLEQSWQIVSEE---LRASGFQLPESLTE 573

  Fly   580 QPLPFDAASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELL 644
            ..:||||||:..:::||.:.::||...|.|....:|::||||||.||||.:.||::...||:||.
Zfish   574 GAVPFDAASDTPVNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGDTFGSVEVEPEEELE 638

  Fly   645 LLREIFMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNP 709
            ||::|..:.:......|...|:       ||.|:.::.||.|..  .::|..|.|.||.:|..:|
Zfish   639 LLKQILFTKLPRTVPLDSAVEE-------EDGDELVEEEELESV--AVSETEFNFLDFIKRFAHP 694

  Fly   710 KIVRACTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEEL 774
            .|||...::|..::.....:......:|||:|...|...:|:|..:|.:|.::.........:||
Zfish   695 NIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQEL 759

  Fly   775 RRLAIFVVRKFVEVAPTNPKIYAELLFYKGIREANELESGYC-DAYEAGTKGAWTEEQESELRFL 838
            .:.|.:|:.:|...|.||.|.:.||||:|.:....|:..||. |...:..|..||.|:|:||:.|
Zfish   760 VKFAKYVLNRFFVFAATNNKAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRL 824

  Fly   839 FEENQRN--PETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKNV--W 899
            :||::.:  |    ||::.:|. |:..:|.||.|:..|..:||:   .:.:..|..:.|..:  |
Zfish   825 YEEHKDSGVP----DVVETLLP-LLSSSRTRREVVSHLVSMGLV---DSVKDLKKEKKGTRIVLW 881

  Fly   900 QPEEDDELRSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGK-- 962
            ..|::.||:.|::..:...|.|..::.....:||:.:|:.::|.:.|::|:.| |..|:.||.
Zfish   882 TEEQEQELQGLFEDFQDSDDVLGNILKRITAKRSRARIVDKILSMGLVSDRKE-LYKKRQRGAHG 945

  Fly   963 ---------------DKPKKDVEMEGEGDEFDFAEEPMFED-QGYKKPKS--KPKKVQKRQMVRT 1009
                           :..:||:|.|.:.||.|..:....|| |.|:|.::  ..||.||    .|
Zfish   946 KSTGMTEEQFFDMTGEMQEKDIEDEEDDDEDDDDKSDQDEDEQHYEKQQTVRSAKKHQK----ST 1006

  Fly  1010 PLDVG-----TIRALIGQVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQ 1065
            ..|:.     ::|.::..:..|.....:.|||..|...::|.||     ||    |.|:||.|..
Zfish  1007 SRDISSEKIHSLRKMVQALQLEGLSGPVLWLQNSLNRTADDREE-----DGVSHPVALVPLTEEN 1066

  Fly  1066 KNAMEDGDFQKVLVALGMQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDED 1130
            ::|||:..|||:|.|:|::.|..|.|.:|||...|:...|    :.||   ...||.:|...:.|
Zfish  1067 EDAMENRSFQKLLRAVGIRAPSEGQETFWRISSSLSVNQL----RTLA---ASLEPLEETGAEGD 1124

  Fly  1131 GEEAE----ESDEEEDFLEKHSRQRKENIATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASE 1191
            .||.:    |.||.|:..::...|....:...:|||..|               .|.||.|.
Zfish  1125 SEEKDSRSVEDDENENDNQEMRAQALRALLLSRQRKHTS---------------AKPKDSPS--- 1171

  Fly  1192 KKAKRKVKGKAKESKDCNDDGTDKAELEKPNTDDLFNQLRAKRATKIKLSDMALNESTNAAQEAD 1256
                             .:|.:|..|..:        |..:|:.:::                .|
Zfish  1172 -----------------QEDISDSVESSE--------QKISKKRSRV----------------LD 1195

  Fly  1257 DDAFNFNSEDYRARLLELEDEEQNSKDADENGGDKENITNKSLQRARRVNVIDSDSDNDDDGALP 1321
            ||      ||       .:||:|....:.|:..|....:.:.:.: :|..|:|.|.::|||
Zfish  1196 DD------ED-------KDDEDQKDSPSQEDISDSVESSEQKISK-KRSRVLDDDDEDDDD---- 1242

  Fly  1322 ADKTNKRPRSDDDGDSGHMDANAEEDSDEEANFLARKKPAKVDGEPAKRRRLAIIDDDDEDD 1383
                                   ::|.|..:....|..||    .|||||...::.|::|:|
Zfish  1243 -----------------------QKDVDPSSRSSERDSPA----APAKRRYTRVLSDEEEED 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	115/259 (44%)
timeout	NP_524341.3	TIMELESS_C	736..1217	CDD:252956	143/518 (28%)
timeless	NP_001265529.1	TIMELESS	25..284	CDD:282651	115/259 (44%)
timeless	NP_001265529.1	TIMELESS_C	721..1275	CDD:252956	174/682 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596649
Domainoid	1	1.000	269	1.000	Domainoid score	I1807
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31206
Inparanoid	1	1.050	673	1.000	Inparanoid score	I706
OMA	1	1.010	-	-		QHG49276
OrthoDB	1	1.010	-	-		D191401at33208
OrthoFinder	1	1.000	-	-		FOG0004685
OrthoInspector	1	1.000	-	-		oto39040
orthoMCL	1	0.900	-	-		OOG6_102693
Panther	1	1.100	-	-	LDO	PTHR22940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1424
SonicParanoid	1	1.000	-	-		X5023
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800