Protein Alignment timeout and timeless

DIOPT Version :10

• Sequence 1: NP_524341.3
• Gene: timeout / 41615
• FlyBaseID: FBgn0038118
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: NP_001265529.1
• Gene: timeless / 325855
• ZFINID: ZDB-GENE-030131-8978
• Length: 1278
• Species: Danio rerio
• Alignment Length: 1427
• Identity: 459/1427 - (32%)
• Similarity: 735/1427 - (51%)
• Gaps: 214/1427 - (14%)

  Fly    10 ATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHE 74
            |||:||||.:|..|..|||..|.:|.||..||.:.|..:.|:.||..::||.||:.::..:...:
Zfish    12 ATCSALGYLEGDVYHKEPDCLESVKDLIRYLRHEDDARDIRQQLGAGQILQNDLLPIITQHTQDK 76

  Fly    75 ELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQA 139
            .|.|..|||:|.||.|.||.:.: .|.|...|..|:::...||.||.|||.:||::.|.|.|...
Zfish    77 PLFDACIRLMVNLTQPALLCFGK-IPDDPAFRHHFLQVTSYLQAYKEAFADEKVFTVLSETLYNL 140

  Fly   140 LEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFV 204
            |::.:..|.||.||||||||:||||||.|||:|..|...|:|||:||:::||:|.:|:.||:.|:
Zfish   141 LQLDWEQRDEEDNLLIERILLLVRNVLHVPADPYEEKNVDDDASVHDKLLWAIHISGLDDLLKFL 205

  Fly   205 ISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQARP-- 267
            ..:..|:|:..|.|||:.|:||:|:||.|..|...||..|||:|.|||...|::|.|.:::|.
Zfish   206 ACAQSEQQWSFHILEIISLMFRDQTAELLVSAGQMRSAQEKQKDMQELELLRQKETAEKRSRTLM 270

  Fly   268 PPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFD---------REKQQQKRSHRHIQEE 323
            ...|||||.|:|||..:||:.:.||:.||.|....|...|         :.||..|.|..|
Zfish   271 RGTRHSRFRGSYVIEGLKSIGENDVVYHQGLHNFKSYSHDLGKAVRRVPKRKQMAKDSDSH---- 331

  Fly   324 AQVTRRSAFTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRL 388
                ||||..|||.|||:||:.|.:.||.|:..|:..|.|.. :..||::|.:||:.|||.||||
Zfish   332 ----RRSALNVRLFLREFCIDFLENCYNRLMYLVKEGLIRER-AQQHDETYYMWALTFFMAFNRL 391

  Fly   389 SGLQLQLVSESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKL 453
            ...:..:|||::|::.||::...:.:..:|:::||..|..|::|:|:||..::|||.::..:.:.
Zfish   392 QNFKPDVVSETISIRTFHFIEKNITNYYEMMLTDKSDATSWSRRMHLALKAYQELLLTVNEMDRS 456

  Fly   454 KDDNNARALFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFC--Q 516
            ||: |.|....::.:|:.|::|:||..|.||..|:|....:.||||:||:|::|::|:||||  :
Zfish   457 KDE-NIRHSSSVIKSNIFYLMEFREIFLTLLRKYDERLQPRSFLRDLVESAHLFLRMLERFCKGR 520

  Fly   517 DSVVVQDKKRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPED--E 579
            :::|||.|:    ..|||:   ::.||..  :.:.|:|...|..::.|   |.::..::||.  |
Zfish   521 NNLVVQKKR----VKRKKR---SQKKPEM--ETSAEDLEQSWQIVSEE---LRASGFQLPESLTE 573

  Fly   580 QPLPFDAASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELL 644
            ..:||||||:..:::||.:.::||...|.|....:|::||||||.||||.:.||::...||:||.
Zfish   574 GAVPFDAASDTPVNEQRTEALVRIQDCLMSRAGPEALSLLRAARAVWPEGDTFGSVEVEPEEELE 638

  Fly   645 LLREIFMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNP 709
            ||::|..:.:......|...|:       ||.|:.::.||.|..  .::|..|.|.||.:|..:|
Zfish   639 LLKQILFTKLPRTVPLDSAVEE-------EDGDELVEEEELESV--AVSETEFNFLDFIKRFAHP 694

  Fly   710 KIVRACTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEEL 774
            .|||...::|..::.....:......:|||:|...|...:|:|..:|.:|.::.........:||
Zfish   695 NIVRPYVILLRSYSQNSPHTNHCVTRMLHRLAVDLKMEALLYQLSVFSLFNKILGDPAAAAYQEL 759

  Fly   775 RRLAIFVVRKFVEVAPTNPKIYAELLFYKGIREANELESGYC-DAYEAGTKGAWTEEQESELRFL 838
            .:.|.:|:.:|...|.||.|.:.||||:|.:....|:..||. |...:..|..||.|:|:||:.|
Zfish   760 VKFAKYVLNRFFVFAATNNKAFVELLFWKNVGAVREMTEGYTKDGEGSKKKSKWTPEEEAELQRL 824

  Fly   839 FEENQRN--PETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKNV--W 899
            :||::.:  |    ||::.:|. |:..:|.||.|:..|..:||:   .:.:..|..:.|..:  |
Zfish   825 YEEHKDSGVP----DVVETLLP-LLSSSRTRREVVSHLVSMGLV---DSVKDLKKEKKGTRIVLW 881

  Fly   900 QPEEDDELRSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGK-- 962
            ..|::.||:.|::..:...|.|..::.....:||:.:|:.::|.:.|::|:.| |..|:.||.
Zfish   882 TEEQEQELQGLFEDFQDSDDVLGNILKRITAKRSRARIVDKILSMGLVSDRKE-LYKKRQRGAHG 945

  Fly   963 ---------------DKPKKDVEMEGEGDEFDFAEEPMFED-QGYKKPKS--KPKKVQKRQMVRT 1009
                           :..:||:|.|.:.||.|..:....|| |.|:|.::  ..||.||    .|
Zfish   946 KSTGMTEEQFFDMTGEMQEKDIEDEEDDDEDDDDKSDQDEDEQHYEKQQTVRSAKKHQK----ST 1006

  Fly  1010 PLDVG-----TIRALIGQVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQ 1065
            ..|:.     ::|.::..:..|.....:.|||..|...::|.||     ||    |.|:||.|..
Zfish  1007 SRDISSEKIHSLRKMVQALQLEGLSGPVLWLQNSLNRTADDREE-----DGVSHPVALVPLTEEN 1066

  Fly  1066 KNAMEDGDFQKVLVALGMQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDED 1130
            ::|||:..|||:|.|:|::.|..|.|.:|||...|:...|    :.||   ...||.:|...:.|
Zfish  1067 EDAMENRSFQKLLRAVGIRAPSEGQETFWRISSSLSVNQL----RTLA---ASLEPLEETGAEGD 1124

  Fly  1131 GEEAE----ESDEEEDFLEKHSRQRKENIATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASE 1191
            .||.:    |.||.|:..::...|....:...:|||..|               .|.||.|.
Zfish  1125 SEEKDSRSVEDDENENDNQEMRAQALRALLLSRQRKHTS---------------AKPKDSPS--- 1171

  Fly  1192 KKAKRKVKGKAKESKDCNDDGTDKAELEKPNTDDLFNQLRAKRATKIKLSDMALNESTNAAQEAD 1256
                             .:|.:|..|..:        |..:|:.:::                .|
Zfish  1172 -----------------QEDISDSVESSE--------QKISKKRSRV----------------LD 1195

  Fly  1257 DDAFNFNSEDYRARLLELEDEEQNSKDADENGGDKENITNKSLQRARRVNVIDSDSDNDDDGALP 1321
            ||      ||       .:||:|....:.|:..|....:.:.:.: :|..|:|.|.::|||
Zfish  1196 DD------ED-------KDDEDQKDSPSQEDISDSVESSEQKISK-KRSRVLDDDDEDDDD---- 1242

  Fly  1322 ADKTNKRPRSDDDGDSGHMDANAEEDSDEEANFLARKKPAKVDGEPAKRRRLAIIDDDDEDD 1383
                                   ::|.|..:....|..||    .|||||...::.|::|:|
Zfish  1243 -----------------------QKDVDPSSRSSERDSPA----APAKRRYTRVLSDEEEED 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	22..281	CDD:461444	115/260 (44%)
		TIMELESS_C	1019..1105	CDD:461529	31/89 (35%)
timeless	NP_001265529.1	TIMELESS	24..284	CDD:461444	115/260 (44%)
		TIMELESS_C	1021..1107	CDD:461529	32/94 (34%)