Protein Alignment timeout and swi1

DIOPT Version :9

• Sequence 1: NP_524341.3
• Gene: timeout / 41615
• FlyBaseID: FBgn0038118
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: NP_595358.1
• Gene: swi1 / 2540728
• PomBaseID: SPBC216.06c
• Length: 971
• Species: Schizosaccharomyces pombe
• Alignment Length: 1375
• Identity: 260/1375 - (18%)
• Similarity: 450/1375 - (32%)
• Gaps: 514/1375 - (37%)

  Fly     8 IDATCAALG---YSDGQKYQAEPDAA----EGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVY 65
            |....:|:|   |||.:|.....|.|    :.||..:.::.......:.|..|...:::..|:..
pombe     7 IQGIVSAIGGFDYSDDEKVYVLGDEALACLKDLKRYLQVVDEKYKVWQIRSLLSSLQLVTNDICP 71

  Fly    66 MLPDY------VHHEELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAA-- 122
            :|.|:      ..:..::...:.|||.||.|.         :..|  :.|.|.:|:|...:.|
pombe    72 ILSDWDKDITNYRNWRIALACVELLVPLTWPL---------ETEH--ETFRENVDVLYNLRQAQS 125

  Fly   123 --------FAKDKVWSALFEKLKQALEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRAD 179
                    :.|..|.||:...|.:.|......|:.....:|..:|:|.||:||:
pombe   126 NYKNSILSYKKGSVLSAILAVLLKPLSTPAESRTLRDKGIIRIVLLLFRNILQI----------- 179

  Fly   180 NDASLHDQVIWALHQTGMLDLVLFVISSPDE-EQFHLHGLEIVCLLFREQSAESL-ADASLQRSL 242
            ::....::.|.:..:..:|||::.::|:.|| |.|.::.||||..|.|.....:| :||||..|.
pombe   180 DELKTKNETIISFAKAHILDLIVTLVSNLDEFEHFDVYILEIVYNLIRGCKPSALFSDASLTNSQ 244

  Fly   243 SE------KQRDQQELLAARRRERARRQARPPPGRHSRFGGTYVIRNMKSVSDRD---VICHQAL 298
            :|      |:..|...|        :|.|..   ||:|||      .|.||...|   .|..|.:
pombe   245 TELNSLLLKESTQNRYL--------KRNAHT---RHNRFG------TMLSVQTEDRRFTIASQNI 292

  Fly   299 ERVSSIDFDREKQQQKRSHRHIQEEAQVTRRSAF-----------TVRLCLREYCIEVLRSAYNT 352
            :.....:.|..|:.:||.          |||..|           .....||.:.:|.|.:.:|.
pombe   293 KTDGLDELDSHKRFRKRG----------TRRKHFDDINKSFFINTEAGTALRNFAVEFLEAGFNP 347

  Fly   353 LVRQVRRVLERNAGSSSHDD--------SYLLWAIRFFMEFNRLSGLQLQLVSESLSVQCFHWVL 409
            |.:.:.:.|||       :|        ..||:...||:||.|.|....:  :|.:....:.:.|
pombe   348 LFQSLLKDLER-------EDPRVLPIHKMQLLYVQSFFLEFMRFSSKPKK--TEEIYSNDYSFGL 403

  Fly   410 TRMQHDMDMIVSDKK------QARLWAKRLHVALLTFRELLQSLLALQKLKDDNNARALFDMLLN 468
            .....|...::...:      :.:.|: ....::|:..:||.:|.::.....:...| :.|.||:
pombe   404 AASVFDQRALIMHNRLMVESFEMKQWS-TFQASMLSMTQLLFTLRSMTLCSSEIYQR-IADNLLS 466

  Fly   469 NVCYVLEYRETVLHLLMNYNEAHSTKVF--LRDVVETANVFIKMMERFCQDSVVVQDKKRGRGAS 531
            |:.    |:|.:|.|:.:..:...|:.|  |..:.|...|.:|.:|:|......:..|||.|
pombe   467 NIF----YQEEILLLVYSALKHFKTQSFGYLDAITELTIVLLKELEKFSSAKQYLYVKKRRR--- 524

  Fly   532 RKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPFDAASEKSIDDQR 596
                                                                    ::||:|
pombe   525 --------------------------------------------------------NQKSVD--- 530

  Fly   597 EDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLLREIFMSNITTVESED 661
                   :.:|.|:: |:..:|:.|              :||.||.|
pombe   531 -------SNVLESDE-DEESSLINA--------------NAAVEDRL------------------ 555

  Fly   662 KENEKDQKQDEYEDEDDDLDNEEYEEQ--DNGLTEKTFKFDDFARRLLNPKIVRACTLVLSDWAD 724
                              .|...||.:  |||.      .|.|             .|.|..:.|
pombe   556 ------------------FDFGRYESRYCDNGC------IDSF-------------VLFLQCYQD 583

  Fly   725 IPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQV------FSVERDVHQEELRRLAIFVVR 783
            :.::.:..|::..:||....||...|::....|:..::      ||......| :..:..::.:|
pombe   584 LDSKQIHRAISFFYRIFVKQKCHVYLYRLDFLRVLDKMFNDHVYFSTTNSARQ-DFEQFFVYYMR 647

  Fly   784 KFVEVAPTNPKIYAELLFYKGIREANELESGYCDAYEAGTKGAWTEEQESELRFLFEENQRNPET 848
            |..:.....|.::.||.|.|.......||.|                 :|.| |....:::.|..
pombe   648 KLSDALKDVPALFIELPFPKLTDTFYYLEYG-----------------KSPL-FSIHGSRKGPLY 694

  Fly   849 DKDVIDWILDNLVDKTRNRRTV--LKKLKELGLLFKAPTKRSTKSAQSGKNVWQPEEDDELRSLY 911
            :                   ||  |..|:::..:. |......||                 .|.
pombe   695 E-------------------TVPGLSHLEKVAAVV-ACLINENKS-----------------DLL 722

  Fly   912 DQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGKDKPKKDVEMEGEGD 976
            |:.:::.:||      .:||:           :..:||:::.:  .:| |.|..:....::|:.|
pombe   723 DELKVQLNCL------ISERK-----------LITLADENKYI--NEG-GNDGERMGKNLKGDTD 767

  Fly   977 EFDFAEEPMFEDQGYKKPKSKPKKVQKRQMVRTPLDVGTIRALIGQVDSEKYQSAIEWLQECLQD 1041
            .|:.|
pombe   768 SFNTA------------------------------------------------------------ 772

  Fly  1042 ASEDTEEAVEDDDGVPLLPLMENQKNAMEDGDFQKVLVALGMQPPISG--MEAYWRIPIYLNSA- 1103
                                      .::||.|:.:|...|.:...:.  ::|.|::|   ||.
pombe   773 --------------------------LLKDGKFRLLLELCGFEESDNNIDVQALWKLP---NSVI 808

  Fly  1104 -DLILRSKILAGEEVDAEPEDEAADDED--------------GEEAEESDEEEDF-----LEKHS 1148
             |.::...:|.....|..|..|....||              ..|.|.||||.:|     :...:
pombe   809 IDELVEHAMLLRRFTDDPPTFEGTKPEDLLVRKQRGNVRLPSSSEGETSDEEIEFEADDPITFAN 873

  Fly  1149 RQRKENIATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASE-------KKAKRKVKGKAKESK 1206
            |:...|..|.::||                       |.|.:|       :|.|......||...
pombe   874 RREALNKITDRKRK-----------------------KMKTNETIIDHTTRKKKENHLRSAKYIV 915

  Fly  1207 DCNDDGTDKAELEKPNTDDLFNQLRAKRATKIKLSDMALNESTNAAQEADDDAFNFNSEDYRARL 1271
            |.:||.         .||..|.|           |:.||.|..  ||:|.......:..:...:|
pombe   916 DSDDDS---------ETDIAFFQ-----------SEAALREKN--AQKASALFKRIDDLEMEGKL 958

  Fly  1272 LELEDEEQNS 1281
            .|:|...:||
pombe   959 QEIEQLSENS 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	67/285 (24%)
		TIMELESS_C	736..1217	CDD:252956	84/518 (16%)
swi1	NP_595358.1	TIMELESS	26..278	CDD:282651	68/290 (23%)
		TIMELESS_C	595..>956	CDD:252956	95/570 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	49	1.000	Domainoid score	I3451
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004685
OrthoInspector	1	1.000	-	-		oto101741
orthoMCL	1	0.900	-	-		OOG6_102693
Panther	1	1.100	-	-	LDO	PTHR22940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1424
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840