Protein Alignment timeout and Timeless

DIOPT Version :9

• Sequence 1: NP_524341.3
• Gene: timeout / 41615
• FlyBaseID: FBgn0038118
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: XP_006513643.1
• Gene: Timeless / 21853
• MGIID: 1321393
• Length: 1258
• Species: Mus musculus
• Alignment Length: 1233
• Identity: 418/1233 - (33%)
• Similarity: 681/1233 - (55%)
• Gaps: 105/1233 - (8%)

  Fly    10 ATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHE 74
            |||:||||.:|..|..|||..|.:|.||..||.:.:..:.|:.||.:::||:||:.:|..:...:
Mouse    73 ATCSALGYLEGGTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHRQDK 137

  Fly    75 ELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQA 139
            .|.|.:|||:|.||.|.||.: ...|||:..|..|::::..||.||.|||.:|.:..|.|.|.:.
Mouse   138 PLFDAVIRLMVNLTQPALLCF-GSVPKDSSVRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYEL 201

  Fly   140 LEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFV 204
            |::.:..|.||.||||||||:||||:|.||||.|.|...|:|||:||:::||:|.:||.||:||:
Mouse   202 LQLGWEDRQEEDNLLIERILLLVRNILHVPANLEQEKSIDDDASIHDRLLWAIHLSGMDDLLLFL 266

  Fly   205 ISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQAR--P 267
            .||..|:|:.||.|||:.|:||:|:.|.||.....|...|:..|..||...|:||.|.::||  .
Mouse   267 SSSSAEQQWSLHVLEIISLMFRDQTPEQLAGVGQGRLAQERSTDVAELEVLRQREMAEKRARALQ 331

  Fly   268 PPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFDREKQQQK-RSHRHIQEEAQVTRRSA 331
            ...|||||||:|:::.:||:.::||:.|:.|..:.:...|..||.:: ...|...:|..|.|||.
Mouse   332 RGNRHSRFGGSYIVQGLKSIGEKDVVFHKGLHNLQNYSSDLGKQPRRVPKRRQAAQELSVHRRSV 396

  Fly   332 FTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRLSGLQLQLV 396
            ..|||.||::|.|.|.:.||.|:..|:..|.|.. :..||::|.:||:.|||.|||.:..:..||
Mouse   397 LNVRLFLRDFCSEFLENCYNPLMGAVKDHLLRER-AQQHDETYYMWAMAFFMAFNRAATFRPGLV 460

  Fly   397 SESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKLKDDNNARA 461
            ||:||::.||:|...:.:..:|:::|:|:|..||:|:|:||..::|||.::..:....|: ..|.
Mouse   461 SETLSIRTFHFVEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDMCPDE-AVRE 524

  Fly   462 LFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFCQD--SVVVQDK 524
            ...::.||:.|::||||..|.|...::|.:..:.||||:|||.::|:||:||||:.  :::||:|
Mouse   525 SSRIIKNNIFYMMEYRELFLALFRKFDERYHPRSFLRDLVETTHLFLKMLERFCRSRGNLMVQNK 589

  Fly   525 KRGRGASRKKK---QAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPED-----EQP 581
            ::.|  .:|||   |....|:.|.       ||.:.|..||.::       |:..:|     :..
Mouse   590 RKKR--KKKKKVQDQGVAFSQSPG-------ELEAMWPALAEQL-------LQCAQDPELSVDPV 638

  Fly   582 LPFDAASEKSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLL 646
            :|||||||..:::||.:.|:||...|.:.:..||:||||:|||||||...||:...:|.:|:.||
Mouse   639 VPFDAASEVPVEEQRVEAMVRIQDCLTAGQAPQALALLRSAREVWPEGNAFGSPVISPGEEMQLL 703

  Fly   647 REIFMSNITTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNPKI 711
            ::|..   |.:..:.:..|.|.:::|.|:|:::|       |...::||.|.|.::.:|..:..|
Mouse   704 KQILS---TPLPRQQEPEEGDAEEEEEEEEEEEL-------QVVQVSEKEFNFLEYLKRFASSTI 758

  Fly   712 VRACTLVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEELRR 776
            |||..|:|..:......:......:|||:|:|.....:|||..||.:|.::.|.......:||..
Mouse   759 VRAYVLLLRSYRQNSAHTNHCIAKMLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVT 823

  Fly   777 LAIFVVRKFVEVAPTNPKIYAELLFYKGIREANELESGYCDAYEAGTKG----AWTEEQESELRF 837
            .|.:::.||..:|..|.|.:.||||:|......|:..|| .:.::|:..    .|:.|:|::|:.
Mouse   824 FAKYIIGKFFALAAVNQKAFVELLFWKNTAVVREMTQGY-GSLDSGSSSHRAPLWSPEEEAQLQE 887

  Fly   838 LFEENQRNPETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKN----V 898
            |:..::  ....:||::.||.:|....|.|:.|:..|..:||      ..|.|..|..|.    :
Mouse   888 LYLAHK--DVEGQDVVETILAHLKVVPRTRKQVIHHLVRMGL------ADSVKEFQKRKGTQIVL 944

  Fly   899 WQPEEDDELRSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGKD 963
            |..:::.||:.|:::.|...|.|.:::.....:||:.:::.::|.:.|::::.::.  ||.|.|.
Mouse   945 WTEDQELELQRLFEEFRDSDDVLGQIMKNITAKRSRARVVDKLLALGLVSERRQLY--KKRRKKL 1007

  Fly   964 KPKKDVEMEGEGDEFD-FAEEPMFEDQGYKKPKSKPKKVQKRQMVRTPLDVG------TIRALIG 1021
            .|  .....||....| :.|:|..||:...:.:|:.::.::    ..|...|      :...|..
Mouse  1008 AP--SCMQNGEKSPRDPWQEDPEEEDEHLPEDESEDEESEE----GLPSGQGQGSSSLSAENLGE 1066

  Fly  1022 QVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQKNAMEDGDFQKVLVALG 1082
            .:..|...:.:.|||..|..|:.|.||     ||    :||:||.|..:.|||:..||.:|..||
Mouse  1067 SLRQEGLSAPLLWLQSSLIRAANDREE-----DGCSQAIPLVPLTEENEEAMENEQFQHLLRKLG 1126

  Fly  1083 MQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDEDGEEAEESDEEEDFLEK- 1146
            ::||.||.|.:||||..|:|..|...:..|:.:|.:.|.|:|......||:....:...:.|..
Mouse  1127 IRPPSSGQETFWRIPAKLSSTQLRRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALRAL 1191

  Fly  1147 -HSRQRKE---------------NIATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASEKK 1193
             .:|:||.               |.|.::::.|||  ..:.|||..::|   ....|:...||
Mouse  1192 LSARKRKAGLGPTEEEATGEEEWNSAPKKRQLLDS--DEEEDDEGRRQA---VSGTPRVHRKK 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
timeout	NP_524341.3	TIMELESS	23..281	CDD:282651	118/259 (46%)
		TIMELESS_C	736..1217	CDD:252956	135/494 (27%)
Timeless	XP_006513643.1	TIMELESS	86..345	CDD:368140	118/259 (46%)
		TIMELESS_C	783..1251	CDD:252956	135/494 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850663
Domainoid	1	1.000	265	1.000	Domainoid score	I1893
eggNOG	1	0.900	-	-		E1_KOG1974
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31206
Inparanoid	1	1.050	649	1.000	Inparanoid score	I785
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49276
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004685
OrthoInspector	1	1.000	-	-		oto94500
orthoMCL	1	0.900	-	-		OOG6_102693
Panther	1	1.100	-	-	LDO	PTHR22940
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1424
SonicParanoid	1	1.000	-	-		X5023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790