DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment timeout and timeless

DIOPT Version :9

Sequence 1:NP_524341.3 Gene:timeout / 41615 FlyBaseID:FBgn0038118 Length:1384 Species:Drosophila melanogaster
Sequence 2:XP_002934575.1 Gene:timeless / 100126683 XenbaseID:XB-GENE-985242 Length:1287 Species:Xenopus tropicalis


Alignment Length:1418 Identity:468/1418 - (33%)
Similarity:736/1418 - (51%) Gaps:187/1418 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 ATCAALGYSDGQKYQAEPDAAEGLKHLIWILRRDLDNHEYRRHLGRSKVLQTDLVYMLPDYVHHE 74
            |||:||||.:...|..|||..|.:|.||..||.:.|..:.|:.||.:::||.||:.::..:.:.:
 Frog    12 ATCSALGYLESDTYHKEPDCLESVKDLIRYLRHEDDTRDIRQQLGAAQILQNDLIPLVIQHHNDK 76

  Fly    75 ELSDLLIRLLVILTNPTLLLYREGAPKDNHGRKVFMELIDILQGYKAAFAKDKVWSALFEKLKQA 139
            :|.|.:|||:|.:|.|.||.:.: .|:|...|..|::::..||.||.|||.::::..|.|||...
 Frog    77 QLFDAVIRLMVNVTQPALLCFGK-VPQDPTFRHHFLQVVSYLQAYKEAFANERLFGVLSEKLYDL 140

  Fly   140 LEIAFAIRSEEQNLLIERILVLVRNVLQVPANPEAECRADNDASLHDQVIWALHQTGMLDLVLFV 204
            |::.:..|.||.||||||||:||||:|.||.:||.|...|:|||:||:|:||:|.:||.||:.|:
 Frog   141 LQMEWEQREEEHNLLIERILLLVRNILHVPPDPEEEKSVDDDASIHDRVLWAIHMSGMDDLIKFL 205

  Fly   205 ISSPDEEQFHLHGLEIVCLLFREQSAESLADASLQRSLSEKQRDQQELLAARRRERARRQAR--P 267
            .||..|:|:.:|.||.|.|:||:|.||.||.....||.:|:..|.:.|...|:||.|.::.|  .
 Frog   206 ASSETEQQWSMHVLETVSLMFRDQIAEHLAATGQARSTAERDTDIKNLEILRQRESAEKKNRALQ 270

  Fly   268 PPGRHSRFGGTYVIRNMKSVSDRDVICHQALERVSSIDFDREKQQQKRSHRHIQ-EEAQVTRRSA 331
            ...|||||||:|:::.:||:.|:|||.|:.:....:...|..|:.::...|..| :|.:..||||
 Frog   271 RGTRHSRFGGSYIVQGLKSIGDKDVIYHKGIHNFKNYTHDLGKEVRRVPKRKQQAKETEARRRSA 335

  Fly   332 FTVRLCLREYCIEVLRSAYNTLVRQVRRVLERNAGSSSHDDSYLLWAIRFFMEFNRLSGLQLQLV 396
            ..|||.|:|:||:.|.:.||.|:..|:..|.|.. :..||::|.||::.|||.||||...|.:||
 Frog   336 LNVRLFLKEFCIDFLENCYNRLMYIVKDNLIREK-AQQHDETYYLWSMAFFMGFNRLFRFQPELV 399

  Fly   397 SESLSVQCFHWVLTRMQHDMDMIVSDKKQARLWAKRLHVALLTFRELLQSLLALQKLKDDNNARA 461
            ||::|::.||::...:.:..:|:::|||:|..||:|:|:||..::|||.::..:...|:: ..|.
 Frog   400 SETVSIRTFHFIEQNLTNYYEMMLTDKKEATSWARRMHLALKAYQELLSTVHEMDHSKEE-AVRE 463

  Fly   462 LFDMLLNNVCYVLEYRETVLHLLMNYNEAHSTKVFLRDVVETANVFIKMMERFC--QDSVVVQDK 524
            ...::.||:.|::||||..|.|...::|....:.||:|:|||.::|:||:|:||  :.:||||.:
 Frog   464 SSKIIKNNIFYLMEYRELFLALFRKFDETKQPRSFLKDLVETTHLFLKMLEKFCKGKQTVVVQKR 528

  Fly   525 KRGRGASRKKKQAATKSKPPAAPQPTEEELSSKWAELATEVCSLLSTELEMPEDEQPLPFDAASE 589
            :    ..||||:::........|:.| |||::.|..::.::.:.:.....:|  :..:|||||||
 Frog   529 R----VKRKKKKSSVSGAKEVQPKST-EELAAIWTNVSEQLTTCIVNSENLP--DSVVPFDAASE 586

  Fly   590 KSIDDQREDCMIRINKLLRSEKLDQAIALLRAAREVWPENEVFGAISAAPEDELLLLREIFMSNI 654
            ..:::||.:.::||...|.|....:|:.|||:|||||||.:||||....||:|..||::|..:.:
 Frog   587 IPVEEQRAEALVRIQDGLFSGCAAEALVLLRSAREVWPEGDVFGAAEIEPEEETELLKQILFAEL 651

  Fly   655 ---TTVESEDKENEKDQKQDEYEDEDDDLDNEEYEEQDNGLTEKTFKFDDFARRLLNPKIVRACT 716
               |..|||....         |:|:|:::.||.....  ::|:.|.|.|:.:|..|..:|:...
 Frog   652 PRSTQAESEVLGE---------EEEEDEIEEEELTSVQ--VSEREFNFLDYMKRFANSNVVKTYV 705

  Fly   717 LVLSDWADIPTRSLKAAVTILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQEELRRLAIFV 781
            |:|.::......:......:||||||..|...:|||..:|.||.::.........:||...:.::
 Frog   706 LLLKNYQQNSAHTNHCVAKMLHRIAYDLKMEALLFQLSVFCIFNKILGDPAASAYKELVAFSKYI 770

  Fly   782 VRKFVEVAPTNPKIYAELLFYKGIREANELESGYC----DAYEAGTKG-AWTEEQESELRFL--- 838
            :.||..:|.||.|.|.||||:|......|:..||.    :..||..|. .||.|.|.|||.|   
 Frog   771 LNKFFSLAATNNKAYVELLFWKNTNVIREMTEGYRKLGEEESEANRKRIKWTPEDEDELRRLYLQ 835

  Fly   839 FEENQRNPETDKDVIDWILDNLVDKTRNRRTVLKKLKELGLLFKAPTKRSTKSAQSGKNV--WQP 901
            |:|.:     |.||:|.|:.||...||.|:.|:..|.::||   |.:.:..|....|..:  |..
 Frog   836 FKEIE-----DADVVDNIVANLKPGTRTRKQVINHLVQMGL---ADSVKDFKQETKGTRIVLWTE 892

  Fly   902 EEDDELRSLYDQHRIEPDCLERLVNEFAERRSKQQIIKRMLQIHLIADKSEILPAKKGRGKDKPK 966
            :::.||:.||:..:...|.|..::.....:|||.:||::::.:.|:.|:.|:...::.:||....
 Frog   893 DQELELQRLYEDFKDSDDILGNIMKNVTAKRSKARIIEKLISMGLVCDRKELYKKRRKKGKSSGM 957

  Fly   967 K-----------------DVEMEGEGDEFDFA-EEPMFEDQGYKKPKSKPKKVQKRQM--VRTPL 1011
            .                 |||.|.|.:|.:.: ||...||..|       |::.|.|.  ...|.
 Frog   958 SEEEFLNDLGFDGKHSVDDVEEEEEEEEEEASEEEEECEDLNY-------KQIAKEQTGGRMDPF 1015

  Fly  1012 DVGTIRALIGQVDSEKYQSAIEWLQECLQDASEDTEEAVEDDDG----VPLLPLMENQKNAMEDG 1072
            ....|:.|:.::..|.....:.|||.||...:||.||     ||    :||:||.|:.::|||:.
 Frog  1016 TDKNIKHLVHKLQQEGLSGPLLWLQNCLNRTAEDREE-----DGSSQAIPLVPLTEDNEDAMENK 1075

  Fly  1073 DFQKVLVALGMQPPISGMEAYWRIPIYLNSADLILRSKILAGEEVDAEPEDEAADDEDGEEAEES 1137
            .|:|:|..||::.|.:..|::||||..|:...|...:..|.       |...|...|....|||.
 Frog  1076 TFKKLLKKLGIRAPANEQESFWRIPGKLSPEQLRKAASCLV-------PLAAAVACEVLANAEEQ 1133

  Fly  1138 DEEEDFLEKHSRQRKENI-ATQQQRKLDSLMFNQSDDETEQRAPPKAKDKPKASEKKAKRKVKGK 1201
                   |.:..||.|.: |....||..|....|...|..|::|    ||...|:.|.:|     
 Frog  1134 -------EVNVEQRAEALRALLLARKKKSSEAQQDLQEENQKSP----DKSLQSQSKTRR----- 1182

  Fly  1202 AKESKDCNDDGTDKAELEKPNTDDLFNQLRAKRATKIKLSDMALNESTNAAQEADDDAFNFNSED 1266
                               |.|        ||:.:|:..||          :|...|..|.|.| 
 Frog  1183 -------------------PKT--------AKKRSKMVDSD----------EENSVDNTNENKE- 1209

  Fly  1267 YRARLLELEDEEQNSKDADENGGDKENITNKSLQRARRVNVIDSDSDN--DDDGALPADKTNKRP 1329
                      .||...||......|.|...||.:|:|   ::|||.|:  ::.|....:...|  
 Frog  1210 ----------SEQLPMDAITERETKPNRPKKSKKRSR---IVDSDDDSVTEEHGKEMLEVDQK-- 1259

  Fly  1330 RSDDDGDSGHMDANAEEDSDEEANFLARKKPAKVDGEPAKRRRLAIIDDDDED 1382
                         .:..:||.|.|.           :|.|::|| :|:|:|||
 Frog  1260 -------------GSFSESDTEENV-----------QPTKKKRL-VIEDEDED 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
timeoutNP_524341.3 TIMELESS 23..281 CDD:282651 114/259 (44%)
TIMELESS_C 736..1217 CDD:252956 151/515 (29%)
timelessXP_002934575.1 TIMELESS 25..284 CDD:398476 114/259 (44%)
TIMELESS_C 1023..1109 CDD:398621 33/90 (37%)
CDC27 <1155..>1287 CDD:370537 49/218 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1760
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H31206
Inparanoid 1 1.050 686 1.000 Inparanoid score I692
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D191401at33208
OrthoFinder 1 1.000 - - FOG0004685
OrthoInspector 1 1.000 - - oto104702
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5023
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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