DRSC/TRiP Functional Genomics Resources

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Protein Alignment sim and ARNT2

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_055677.3 Gene:ARNT2 / 9915 HGNCID:16876 Length:717 Species:Homo sapiens


Alignment Length:701 Identity:166/701 - (23%)
Similarity:272/701 - (38%) Gaps:138/701 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLK-MRQVFPDGLGEAWG 89
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::| ||     |.|....
Human    65 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR-----GTGNKST 124

  Fly    90 SSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .........|.:||...:|:..|||:||||.: |:::|:|::.:..|...|.|..|::::|.:|.
Human   125 DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHP 189

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKC---- 214
            .|.:::...|....:.....:....|......|.|  |:.....||     .::|..||:|    
Human   190 DDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQ--SSMRMCMGS-----RRSFICRMRCGNAP 247

  Fly   215 ----------VLAKR---NAGLTTSG---FKVIHCSGYLKARIYP---------DRGDGQGSLIQ 254
                      .:.||   ..|....|   :.|:||:||:||  :|         |...||||   
Human   248 LDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKA--WPPAGMTIPEEDADVGQGS--- 307

  Fly   255 NLGLVAVGH-SLPSSAI----------TEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDL 308
            ...|||:|. .:.||.:          ||       |:.|...|..:.|.|.|...:.||:||||
Human   308 KYCLVAIGRLQVTSSPVCMDMNGMSVPTE-------FLSRHNSDGIITFVDPRCISVIGYQPQDL 365

  Fly   309 IEKTLYQYIHAADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVF 372
            :.|.:.::.|..|...:|.| .|::..||||.:..|||.||...|:.:::.:....|..|....:
Human   366 LGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEY 430

  Fly   373 IVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQ 437
            |:..|     ..||.|...:.:..|.:|:.:| :...:|.......|...:|.::...|.|:.:|
Human   431 IICTN-----TNVKQLQQQQAELEVHQRDGLS-SYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQ 489

  Fly   438 ----------VVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTP 492
                      ..:...:..::....|..|.|....|:|.....|..           ....:|..
Human   490 ERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGK-----------AFSSSVVH 543

  Fly   493 VPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSA 557
            ||..|:..|||:....:        .|.|..::...:::|...||.....:.|.||   .|.||.
Human   544 VPGVNDIQSSSSTGQNM--------SQISRQLNQSQVAWTGSRPPFPGQQIPSQSS---KTQSSP 597

  Fly   558 GGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSS 622
            .|           ..|...||...:             .|......|||     |.:.|:.||.:
Human   598 FG-----------IGTSHTYPADPS-------------SYSPLSSPATS-----SPSGNAYSSLA 633

  Fly   623 ESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQ 673
            ..    :.|.|.....:...|...|::...::..:....|.:||.|||..|
Human   634 NR----TPGFAESGQSSGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQ 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 17/60 (28%)
PAS 102..215 CDD:395786 31/127 (24%)
PAS_3 291..377 CDD:430001 28/86 (33%)
ARNT2NP_055677.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..74 1/8 (13%)
bHLH-PAS_ARNT 62..124 CDD:381517 18/63 (29%)
PAS 137..243 CDD:395786 30/112 (27%)
PAS_11 336..436 CDD:464214 33/111 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..717 38/177 (21%)
Blue background indicates that the domain is not in the aligned region.

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