Protein Alignment sim and CLOCK

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_004889.1
• Gene: CLOCK / 9575
• HGNCID: 2082
• Length: 846
• Species: Homo sapiens
• Alignment Length: 865
• Identity: 190/865 - (21%)
• Similarity: 300/865 - (34%)
• Gaps: 284/865 - (32%)

  Fly    26 KEKSKNAARTRREKE-----NTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMR-----QVF 80
            |:|:|..:|.:.||:     |....||..:||..|   .::||::|::.:..:|:..     |..
Human    31 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLRKHKEITAQSD 92

  Fly    81 PDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 145
            ...:.:.|  .|.........:|   :|:.||||...:..||.|:|:||:.:..|.....:|...
Human    93 ASEIRQDW--KPTFLSNEEFTQL---MLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ 152

  Fly   146 SIFEYIHNYDQDEMNAILSLH--------PHI----NQ-----HPLAQTHTPIGSPNGVQHPSAY 193
            |||.:|...:..|:..|||.|        |..    ||     |.|..|..|       :.||.|
Human   153 SIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDP-------KEPSTY 210

  Fly   194 DHDR--GSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNL 256
            ::.:  |:         |..:..|.:..:     :||:     |.::....|...|       .:
Human   211 EYVKFIGN---------FKSLNSVSSSAH-----NGFE-----GTIQRTHRPSYED-------RV 249

  Fly   257 GLVAVGHSLPSSAITE---IKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIH 318
            ..||.........|.|   ::.....|..|..|:.|.:|.|.|...:.||.|.:::..:.|.|.|
Human   250 CFVATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH 314

  Fly   319 AADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSER 383
            ..|:..:...|:.|:..|:..:.||||||||..|:|:|::..:.::..:||..|||..:.|:|..
Human   315 VDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYA 379

  Fly   384 EV-----KDLVL------------------NEIQTGVVKREPI-------SPAAQAAQAAQAAQA 418
            ||     ::|.:                  |.|.| |..:|.:       :|:|.:..:.:::..
Human   380 EVRAERRRELGIEESLPETAADKSQDSGSDNRINT-VSLKEALERFDHSPTPSASSRSSRKSSHT 443

  Fly   419 AQAAQAA--------------------------QAAHVAQAVQAQVVVVPQQSVVVQPQCAGATG 457
            |.:..::                          :::..:|::.:|.|    .|.:.||..:.||.
Human   444 AVSDPSSTPTKIPTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSV----GSSLTQPVMSQATN 504

  Fly   458 QPVGPGT---PVSLALSASPKLDPYFEP-------------------------------ELPLQP 488
            .|:..|.   ..|..|.|...|....|.                               ::.||.
Human   505 LPIPQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQEELRKIQEQLQMVHGQGLQMFLQQ 569

  Fly   489 A---------------------VTP------VPPTNNSSSSSNNNNGVWHHHHVQQQ-------- 518
            :                     :.|      |.|||...|..|..:.....|.:|||
Human   570 SNPGLNFGSVQLSSGNSSNIQQLAPINMQGQVVPTNQIQSGMNTGHIGTTQHMIQQQTLQSTSTQ 634

  Fly   519 -QQ---SGSMDHDSL-SYTQ--LYPPLNDLVVSSSSSVGG--GTASSAGGGSSASAS-------- 566
             ||   ||.....|| |.||  |..||.:.:|.|..:.|.  ...||....|:.||:
Human   635 SQQNVLSGHSQQTSLPSQTQSTLTAPLYNTMVISQPAAGSMVQIPSSMPQNSTQSAAVTTFTQDR 699

  Fly   567 ----SSG------------------VYSTEMQ------YPDTTTGNLYYNNNNHYYYDYDATVDV 603
                |.|                  |.||.:.      ||                     |...
Human   700 QIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYP---------------------TFAT 743

  Fly   604 ATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQ-------------TTYSDLSHNFEL 655
            .....:..|........||:.::..|....|....|.|.|             :|...||..|.|
Human   744 QQQQSQTLSVTQQQQQQSSQEQQLTSVQQPSQAQLTQPPQQFLQTSRLLHGNPSTQLILSAAFPL 808

  Fly   656 --SYFSDNSSQQHQHQQQQQ 673
              |.|..:..||||.|||||
Human   809 QQSTFPQSHHQQHQSQQQQQ 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	17/69 (25%)
		PAS	102..215	CDD:395786	35/131 (27%)
		PAS_3	291..377	CDD:430001	29/85 (34%)
CLOCK	NP_004889.1	bHLH-PAS_CLOCK	29..89	CDD:381577	16/60 (27%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785	32..47		5/14 (36%)
		PAS	109..>175	CDD:395786	23/68 (34%)
		PAS_11	274..377	CDD:464214	34/102 (33%)
		Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785	371..845		93/484 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411		0/18 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..495		7/78 (9%)
		Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785	450..570		17/123 (14%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564		5/49 (10%)
		SP1-4_N	550..>694	CDD:425404	33/143 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..654		10/29 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..783		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..846		11/18 (61%)