Protein Alignment sim and hif1aa

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001295488.1
• Gene: hif1aa / 797150
• ZFINID: ZDB-GENE-080917-55
• Length: 717
• Species: Danio rerio
• Alignment Length: 678
• Identity: 194/678 - (28%)
• Similarity: 304/678 - (44%)
• Gaps: 133/678 - (19%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||.||.||:..|.||::.||||.::||.||||||:||..|||::|::.         :
Zfish    17 KEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLL---------N 72

  Fly    91 SPAMQRGATI-KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154
            |..:::...: .:.....|:.||||:.|::.||.|:|:||..|..|||.|:||||:|:||:.|..
Zfish    73 SDVLEKETALDTQWNGSFLKALDGFLLVLSADGDIVYLSENVSKCLGLPQIELTGHSVFEFTHPC 137

  Fly   155 DQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK- 218
            |.:|:..:|:                          ..:...:.|......::|.|||||.|..
Zfish   138 DHEELREMLA--------------------------HRFGLSKKSKDQNTNRSFLLRMKCTLTSR 176

  Fly   219 -RNAGLTTSGFKVIHCSGYLKARIYPDRGDG-QGSLIQNLG-----LVAVGHSLPSSAITEIKLH 276
             |...:.::.:||:.|||    ||:  ..|| :..:.:...     ||.:..|:|..|..|..|.
Zfish   177 GRTVNVKSASWKVLRCSG----RIH--TADGVEKEVCEEKNTCSTYLVLICESIPHPANIEAPLD 235

  Fly   277 QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTK 341
            ...|:.|..|||:..:.|.|:::|.|::|:|:::.::|:|.||.|...|..:|..|..||||.|.
Zfish   236 SRTFLSRHTLDMRFTYCDERITELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQVCTG 300

  Fly   342 YYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLS--EREVKDLVLNEIQTGVVKREPIS 404
            .||.|.|.||:||.::.||:::||::|:...:|.|||:||  |:..:.|.|.:..:..:|:|...
Zfish   301 QYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEHQ 365

  Fly   405 PAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPV--- 466
            ...:...|....:..:..:..:     :.||.          |||........:.:....||
Zfish   366 EEVEVTMAELKEEEKEMDKEDE-----ECVQP----------VVQHNSLKGETEALTVADPVLTL 415

  Fly   467 -----SLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNN---NNGVWHHHHVQQQQQSGS 523
                 ..|:|...::..|.:..||....:.|:.|.:...||.|:   :.|...|.....||.|.|
Zfish   416 DINITDSAISVLTEIPLYNDVMLPSSDVLLPLSPLSPPCSSLNDDEASTGHLQHDQFPFQQSSDS 480

  Fly   524 ------MDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGV-YSTEMQYPDTT 581
                  :..||....||.|   |.|....|             ....:.:.|| ...||..|
Zfish   481 SRSQVDLPVDSELCDQLKP---DHVEKHFS-------------MDIESKTQGVGLDLEMLAP--- 526

  Fly   582 TGNLYYNNNNHYYYDYDATVDVAT-SMIRPFSANSNSC-------SSSSESERQLSTGNASIVNE 638
                        |...|....:.| |.:||..  |:.|       |||:::...||......::
Zfish   527 ------------YIPMDDDFQLRTVSPVRPMC--SSPCSGLDLTPSSSTQTSPALSAATPDSLS- 576

  Fly   639 TSPSQ----TTYSDLSHNFELSYFSDNS 662
            ..|.|    ||..|  |:.|:...||.|
Zfish   577 CDPVQQKNKTTVQD--HSREIIQDSDIS 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	32/59 (54%)
		PAS	102..215	CDD:395786	34/112 (30%)
		PAS_3	291..377	CDD:430001	33/85 (39%)
hif1aa	NP_001295488.1	bHLH_SF	11..79	CDD:469605	33/70 (47%)
		PAS	85..150	CDD:214512	28/90 (31%)
		PAS	236..335	CDD:238075	38/98 (39%)
		HIF-1	<519..541	CDD:463274	6/36 (17%)
		HIF-1a_CTAD	683..716	CDD:430212