DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sim and hif1aa

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001295488.1	Gene:	hif1aa / 797150	ZFINID:	ZDB-GENE-080917-55	Length:	717	Species:	Danio rerio

Alignment Length:	678	Identity:	194/678 - (28%)
Similarity:	304/678 - (44%)	Gaps:	133/678 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||.||.||:..|.||::.||||.::||.||||||:||..|||::|::.         :
Zfish    17 KEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLL---------N 72

  Fly    91 SPAMQRGATI-KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154
            |..:::...: .:.....|:.||||:.|::.||.|:|:||..|..|||.|:||||:|:||:.|..
Zfish    73 SDVLEKETALDTQWNGSFLKALDGFLLVLSADGDIVYLSENVSKCLGLPQIELTGHSVFEFTHPC 137

  Fly   155 DQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK- 218
            |.:|:..:|:                          ..:...:.|......::|.|||||.|..
Zfish   138 DHEELREMLA--------------------------HRFGLSKKSKDQNTNRSFLLRMKCTLTSR 176

  Fly   219 -RNAGLTTSGFKVIHCSGYLKARIYPDRGDG-QGSLIQNLG-----LVAVGHSLPSSAITEIKLH 276
             |...:.::.:||:.|||    ||:  ..|| :..:.:...     ||.:..|:|..|..|..|.
Zfish   177 GRTVNVKSASWKVLRCSG----RIH--TADGVEKEVCEEKNTCSTYLVLICESIPHPANIEAPLD 235

  Fly   277 QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTK 341
            ...|:.|..|||:..:.|.|:::|.|::|:|:::.::|:|.||.|...|..:|..|..||||.|.
Zfish   236 SRTFLSRHTLDMRFTYCDERITELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQVCTG 300

  Fly   342 YYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLS--EREVKDLVLNEIQTGVVKREPIS 404
            .||.|.|.||:||.::.||:::||::|:...:|.|||:||  |:..:.|.|.:..:..:|:|...
Zfish   301 QYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEHQ 365

  Fly   405 PAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPV--- 466
            ...:...|....:..:..:..:     :.||.          |||........:.:....||
Zfish   366 EEVEVTMAELKEEEKEMDKEDE-----ECVQP----------VVQHNSLKGETEALTVADPVLTL 415

  Fly   467 -----SLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNN---NNGVWHHHHVQQQQQSGS 523
                 ..|:|...::..|.:..||....:.|:.|.:...||.|:   :.|...|.....||.|.|
Zfish   416 DINITDSAISVLTEIPLYNDVMLPSSDVLLPLSPLSPPCSSLNDDEASTGHLQHDQFPFQQSSDS 480

  Fly   524 ------MDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGV-YSTEMQYPDTT 581
                  :..||....||.|   |.|....|             ....:.:.|| ...||..|
Zfish   481 SRSQVDLPVDSELCDQLKP---DHVEKHFS-------------MDIESKTQGVGLDLEMLAP--- 526

  Fly   582 TGNLYYNNNNHYYYDYDATVDVAT-SMIRPFSANSNSC-------SSSSESERQLSTGNASIVNE 638
                        |...|....:.| |.:||..  |:.|       |||:::...||......::
Zfish   527 ------------YIPMDDDFQLRTVSPVRPMC--SSPCSGLDLTPSSSTQTSPALSAATPDSLS- 576

  Fly   639 TSPSQ----TTYSDLSHNFELSYFSDNS 662
            ..|.|    ||..|  |:.|:...||.|
Zfish   577 CDPVQQKNKTTVQD--HSREIIQDSDIS 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	31/51 (61%)
		PAS	102..215	CDD:279347	34/112 (30%)
		PAS	102..163	CDD:214512	27/60 (45%)
		PAS	278..376	CDD:238075	38/97 (39%)
		PAS_3	291..377	CDD:285623	33/85 (39%)
hif1aa	NP_001295488.1	HLH	13..71	CDD:238036	32/53 (60%)
		PAS	85..150	CDD:214512	28/90 (31%)
		PAS	236..335	CDD:238075	38/98 (39%)
		PAS_3	249..336	CDD:285623	33/86 (38%)
		HIF-1	<519..541	CDD:288296	6/36 (17%)
		HIF-1a_CTAD	683..716	CDD:285931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810