Protein Alignment sim and SIM1

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_005059.2
• Gene: SIM1 / 6492
• HGNCID: 10882
• Length: 766
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 319/730 - (43%)
• Similarity: 386/730 - (52%)
• Gaps: 160/730 - (21%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWG 89
            |||||||||||||||||:||.|||||||||:||||||||||:|||||||||||.|||:|||||||
Human     1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWG 65

  Fly    90 ----SSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEY 150
                :||....|   :||||||||||||||||||||||||||||||||||||||||||||||:||
Human    66 HSSRTSPLDNVG---RELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEY 127

  Fly   151 IHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCV 215
            ||..|.|||.|:|:.|...:.|.:.:                         .|||::||||||||
Human   128 IHPADHDEMTAVLTAHQPYHSHFVQE-------------------------YEIERSFFLRMKCV 167

  Fly   216 LAKRNAGLTTSGFKVIHCSGYLKARIYP-DRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNM 279
            |||||||||..|:||||||||||.|.|. |.....| ..||:||||||||||.||:||||||.||
Human   168 LAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG-CYQNVGLVAVGHSLPPSAVTEIKLHSNM 231

  Fly   280 FMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYR 344
            |||||.|||||||.|:||::|||||||||||||||.::|..|...:||:|.:||.||||||||||
Human   232 FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296

  Fly   345 FLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQA 409
            ||.|.|||||||||||:||||||||...||||||||::.|.|.|.|:..|....|     ||...
Human   297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASK-----PAFSY 356

  Fly   410 AQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASP 474
            ..::.... ....:.|::...:...:::....||.|.....:.........| |:|  |..:|||
Human   357 TSSSTPTM-TDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWG-GSP--LTDTASP 417

  Fly   475 K-LDP------------------------------------------------------YF--EP 482
            : |||                                                      ||  .|
Human   418 QLLDPADRPGSQHDASCAYRQFSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTP 482

  Fly   483 ELPLQP-----AVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLV 542
            :...:|     |..|:...:..|..:..|: :.|...|.:....|..|.||             |
Human   483 QAGREPWWGSRAALPLTKASPESREAYENS-MPHIASVHRIHGRGHWDEDS-------------V 533

  Fly   543 VSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSM 607
            |||...   |:||.:|..          |.||.           |.::.|.....:..:.....|
Human   534 VSSPDP---GSASESGDR----------YRTEQ-----------YQSSPHEPSKIETLIRATQQM 574

  Fly   608 IRPFSANSNSCSSSSESERQLSTGNAS-------IVNETSPSQTTYSDLSHNFELSYFSDNSSQQ 665
            |:   ...|..........||::.|.:       ..|...|..|  .::.|...|:     ::..
Human   575 IK---EEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPT--GEVCHGSALA-----NTSP 629

  Fly   666 HQHQQQQQHLMEQQH 680
            ..|.||::..|...|
Human   630 CDHIQQREGKMLSPH 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	54/60 (90%)
		PAS	102..215	CDD:395786	67/112 (60%)
		PAS_3	291..377	CDD:430001	62/85 (73%)
SIM1	NP_005059.2	bHLH-PAS_SIM1	1..71	CDD:381581	59/69 (86%)
		PAS	88..>158	CDD:238075	51/94 (54%)
		PAS_3	243..329	CDD:430001	62/85 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..431		15/81 (19%)
		SIM_C	359..669	CDD:461963	57/338 (17%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..563		16/71 (23%)