Protein Alignment sim and arnt2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_009301213.1
• Gene: arnt2 / 64277
• ZFINID: ZDB-GENE-001207-3
• Length: 738
• Species: Danio rerio
• Alignment Length: 700
• Identity: 158/700 - (22%)
• Similarity: 274/700 - (39%)
• Gaps: 130/700 - (18%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLK-MRQVFPDGLGEAWG 89
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::| ||     |.|....
Zfish    80 RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMR-----GTGNTST 139

  Fly    90 SSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            .........|.:||...:|:..|||:||||.: |:::|:|::.:..|...|.|..|:::||.:|.
Zfish   140 DGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNHPQSEWFGSTLFEQVHP 204

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLA- 217
            .|.|::...||...:.....:....|......|.|  |:.....||     .::|..||:|..|
Zfish   205 DDVDKLREQLSTSENSMTGRILDLKTGTVKKEGQQ--SSMRMCMGS-----RRSFICRMRCGSAP 262

  Fly   218 ----------------KRNAGLTTSG---FKVIHCSGYLKARIYPDRG------DGQGSLIQNLG 257
                            :...|.:..|   :.|:||:||:||  :|..|      |.:........
Zfish   263 LDHISLNRLSSMRKRYRNGLGPSKEGEAQYSVVHCTGYIKA--WPPAGMTIPDEDTEAGQTSKYC 325

  Fly   258 LVAVGHSLPSSAITEIKLH----QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIH 318
            |||:|....:|:...:.::    ...|:.|...|..:.|.|.|...:.||:||||:.|.:.::.|
Zfish   326 LVAIGRLQVTSSPVSMDMNGLSVPTEFLSRHNSDGIITFVDPRCINVIGYQPQDLLGKDILEFCH 390

  Fly   319 AADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSE 382
            ..|...:|.| .|::..||||.:..|||..|...|:.:::.:....|..|....:|:..|
Zfish   391 PEDQSHLRESFQQVVKLKGQVLSVMYRFRMKNREWMLIRTSSFTFQNPYSDEIEYIICTN----- 450

  Fly   383 REVKDL-VLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQV-------- 438
            ..||.| ...:.:..|.:|:.:: |...:|...:..:|...::.::....:::.:|.
Zfish   451 TNVKQLQQQQQAELEVHQRDGLT-AYDLSQVPVSGVSAGVHESGKSIDKTESLFSQERDPRFSDI 514

  Fly   439 ---VVVPQQSVVVQPQCAG-----ATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPP 495
               :...::.::|....:|     :.|.|..||.. ..:.|:|                |..||.
Zfish   515 YTGISTSEKKMMVPSSTSGGQQLYSQGSPFQPGHS-GKSFSSS----------------VIHVPG 562

  Fly   496 TNN--SSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAG 558
            .|:  |::.|...|.......:...|.|.|.:....|..|..|..::...||...:|...:..|.
Zfish   563 VNDIQSTAGSAGQNLSQISRQINTGQVSWSGNRPPFSGQQQIPAQSNKAQSSPFGIGSSHSYQAD 627

  Fly   559 GGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSE 623
            ..|.:..||....|        .:||.|.|..|.     :...||:              ..||:
Zfish   628 PSSYSPLSSPATSS--------PSGNAYSNLANR-----NTAFDVS--------------GESSQ 665

  Fly   624 SERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQ 673
            |..|.              |...|::...::..:.|..:...|.|.|..|
Zfish   666 SGGQF--------------QGRPSEVWSQWQSQHHSQQAGDPHPHTQASQ 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	17/60 (28%)
		PAS	102..215	CDD:395786	33/113 (29%)
		PAS_3	291..377	CDD:430001	27/86 (31%)
arnt2	XP_009301213.1	bHLH-PAS_ARNT	75..139	CDD:381517	18/63 (29%)
		PAS	152..258	CDD:395786	33/112 (29%)
		PAS_11	351..451	CDD:464214	31/104 (30%)