Protein Alignment sim and NPAS3

DIOPT Version :9

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_016877071.1
• Gene: NPAS3 / 64067
• HGNCID: 19311
• Length: 986
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 235/848 - (27%)
• Similarity: 364/848 - (42%)
• Gaps: 235/848 - (27%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDG------- 83
            ||||::|||:||.|||.||.||||||||||||||||||||:||||.||||||.....|
Human    89 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLR 153

  Fly    84 ----------LG-EAWGSSPAMQR------GATIK-------------ELGSHLLQTLDGFIFVV 118
                      .| :.|.|...|::      ||..:             .||||:||:||||:|.:
Human   154 MEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFAL 218

  Fly   119 APDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQ------- 176
            ..:||.:|||||.|::||||||||||:|:|:|:|..|..||...|.:.....:..|:|
Human   219 NQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGA 283

  Fly   177 ----------THTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVI 231
                      |..|:.|.:    ||....|.     .:|::||:|||..|.||...:.:||:|||
Human   284 SSASSSSQSETPEPVESTS----PSLLTTDN-----TLERSFFIRMKSTLTKRGVHIKSSGYKVI 339

  Fly   232 HCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDAR 296
            |.:|.|:.|:....|....|  |.:|||.|.|:||...|.|:::..:||:.|..:|:.:|:.:.|
Human   340 HITGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENR 402

  Fly   297 VSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATL 361
            :|......|.|::.|..|.:|||.|:..:|.||..||.|||..|||||::.|.||::|:||.||:
Human   403 ISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATI 467

  Fly   362 VHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQ------------------------TGVVKREP 402
            ..|::::.|..|:.|||:||..|.||..::..|                        :|:.:...
Human   468 AINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNE 532

  Fly   403 ISPAAQAAQAAQAAQAAQ--------------------------------------------AAQ 423
            .|.:.:....::.::..:                                            |.:
Human   533 NSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGE 597

  Fly   424 AAQAAHVAQAVQAQVVVVPQQSVVVQPQC-------------AGATG----------------QP 459
            ....|..|..::.:..|..:..:.:| .|             ||..|                |.
Human   598 DGFGALGAMQIKVERYVESESDLRLQ-NCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQK 661

  Fly   460 VGPGTPVSLALSASP------KLDPYFEPEL---PLQPAVTPVPPTNNSSSSSNNNNGVWHHHHV 515
            .|..:...|:.::||      .::|   |.|   |...:|..:....:...:.:|::.:|::
Human   662 GGSASRRRLSSASSPGGLDAGLVEP---PRLLSSPNSASVLKIKTEISEPINFDNDSSIWNY--- 720

  Fly   516 QQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGG---------------TASSAGG------ 559
               ..:..:..:...|:...||.::...|.....|||               |...|.|
Human   721 ---PPNREISRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKT 782

  Fly   560 --GSSASASSSGVYSTEMQYP------DTTTGN---------------LYYNNNNHYYYDYDATV 601
              |:||:|:.:.|.|..:..|      |...||               ...:|:..|..|.:|..
Human   783 QFGASATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQ 847

  Fly   602 DV-ATSMIRPF--SANSNSCSSSSESERQLSTGNASIVNETSPSQTT---YSDLSHNFELSYFSD 660
            .: |.:::.|.  .......::|:.::|..:||..    ..:|::.|   .|:|..|.....|.|
Human   848 RLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTI----RYAPAEVTLAMQSNLLPNAHAVNFVD 908

  Fly   661 NSS 663
            .:|
Human   909 VNS 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	43/51 (84%)
		PAS	102..215	CDD:279347	51/129 (40%)
		PAS	102..163	CDD:214512	36/60 (60%)
		PAS	278..376	CDD:238075	39/97 (40%)
		PAS_3	291..377	CDD:285623	35/85 (41%)
NPAS3	XP_016877071.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850