DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sim and Clock

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_001376183.1 Gene:Clock / 60447 RGDID:620271 Length:864 Species:Rattus norvegicus


Alignment Length:816 Identity:182/816 - (22%)
Similarity:297/816 - (36%) Gaps:227/816 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKE-----NTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMR-----QVF 80
            |:|:|..:|.:.||:     |....||..:||..|   .::||::|::.:..:|:..     |..
  Rat    31 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNA---RKMDKSTVLQKSIDFLRKHKEITAQSD 92

  Fly    81 PDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 145
            ...:.:.|  .|.........:|   :|:.||||...:..||.::|:|||.:..|.....:|...
  Rat    93 ASEIRQDW--KPTFLSNEEFTQL---MLEALDGFFLAIMTDGSVVYVSETVTSLLEHLPSDLVDQ 152

  Fly   146 SIFEYIHNYDQDEMNAILSLH------------PHINQ-----HPLAQTHTPIGSPNGVQHPSAY 193
            |||.:|...:..|:..|||.|            ...||     |.|..|..|       :.||.|
  Rat   153 SIFNFIPEGEHSEVYKILSTHLLESDSLTPEDLKSKNQLEFCCHMLRGTIDP-------KEPSTY 210

  Fly   194 DHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGL 258
            ::.|          |....|.:.:...:  |.:||:     |.::....|...|       .:..
  Rat   211 EYVR----------FIGNFKSLNSVSTS--THNGFE-----GTIQRTHRPSYED-------RVCF 251

  Fly   259 VAVGHSLPSSAITE---IKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAA 320
            ||.........|.|   ::.....|..|..|:.|.:|.|.|...:.||.|.:::..:.|.|.|..
  Rat   252 VATVRLATPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVD 316

  Fly   321 DIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREV 385
            |:.::...|:.|:..|:..:.||||||||..|:|:|::..:.::..:||..|||..:.|:|..||
  Rat   317 DLESLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEV 381

  Fly   386 -----KDLVL------------------NEIQTGVVKREPI-------SPAAQAAQAAQAAQAAQ 420
                 ::|.:                  |.|.| |..:|.:       :|:|.:..:.:::..|.
  Rat   382 RAERRRELGIEESLPETAADKSQDSGSDNRINT-VSLKEALERFDHSPTPSASSRSSRKSSHTAV 445

  Fly   421 AAQAA--------------------------QAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQP 459
            :..::                          :::..:|::.:|.|    .|.:.||..:.|...|
  Rat   446 SDPSSTPTKIPTDTSTPPRPHLPAHEKMTQRRSSFSSQSINSQSV----GSSLTQPAMSQAANLP 506

  Fly   460 VGPGT---PVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQ--- 518
            :..|.   .:|..|.|...|....|....:..|              |.:........:|:|   
  Rat   507 IPQGMSQFQLSAQLGAMQHLKDQLEQRTRMIEA--------------NIHRQQEELRKIQEQLQM 557

  Fly   519 ----------QQS------GSMDHDS--LSYTQLYP--------PLNDLVVSSSSSVGGG----- 552
                      |||      ||:...|  .:..||.|        |:|.:    .|.|..|     
  Rat   558 VHGQGLQMFLQQSNPGLNFGSVQLSSGNSNIQQLTPINMQGQVVPVNQI----QSGVNAGHVSTG 618

  Fly   553 ----------TASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSM 607
                      :.|:.....|..:..|...|...|.|.|.|..||    |.......|    |.||
  Rat   619 QHMIQQQTLQSTSTQQSQQSVMSGHSQPTSLPNQTPSTLTAPLY----NTMVISQPA----AGSM 675

  Fly   608 IR-PFSANSNSCSSSS----ESERQL--STGNASIVNETS----------PSQ-------TTYSD 648
            :. |.|...||..|::    ..:||:  |.|...:....:          ||.       |.|..
  Rat   676 VPIPSSMPQNSTQSATVTTFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPT 740

  Fly   649 LSHNFELSYFSDNSSQQHQHQQQQQHLMEQQHLQYQ 684
            .:...:.:.....:.||.|.|||||...:||..|.|
  Rat   741 FATQQQQAQALSVTQQQQQQQQQQQQQQQQQPQQAQ 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 17/69 (25%)
PAS 102..215 CDD:395786 35/129 (27%)
PAS_3 291..377 CDD:430001 29/85 (34%)
ClockNP_001376183.1 bHLH-PAS_CLOCK 29..89 CDD:381577 16/60 (27%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785 32..47 5/14 (36%)
PAS 109..202 CDD:395786 27/95 (28%)
PAS_11 274..377 CDD:464214 34/102 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..497 13/113 (12%)
Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785 450..570 19/137 (14%)
Implicated in the circadian rhythmicity. /evidence=ECO:0000250 514..564 9/63 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..864
Blue background indicates that the domain is not in the aligned region.

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