Protein Alignment sim and bmal2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_571653.3
• Gene: bmal2 / 58099
• ZFINID: ZDB-GENE-000509-2
• Length: 631
• Species: Danio rerio
• Alignment Length: 590
• Identity: 154/590 - (26%)
• Similarity: 236/590 - (40%)
• Gaps: 136/590 - (23%)

  Fly    21 KTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLG 85
            |...::|......:.||:|.|....|||.::|....::.:|||.:|:|:...:||..:.......
Zfish    86 KIKCIREPHSQIEKRRRDKMNNLIDELAAMIPTCNPMSRKLDKLTVLRMAVQHLKSLKGATSSFA 150

  Fly    86 EAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFE 149
            || ...||......:|.|   :|:..|||:|||..| |||:::||:.|..|..|:.||.|.|:|:
Zfish   151 EA-NYKPAFLPDDELKHL---VLRAADGFLFVVGCDRGKIVFVSESVSKTLNYSRTELIGQSLFD 211

  Fly   150 YIHNYDQDEMNAILS---LHPH-----INQHPLAQTHTPIGSP---NGVQHPSAYDHDRGSHTIE 203
            |:|..|..::...||   |:|.     .......|...|:||.   :|.:
Zfish   212 YVHPKDIGKVKEQLSASELYPRERLIDAKTGLQVQAELPVGSARLCSGAR--------------- 261

  Fly   204 IEKTFFLRMKC--VLAKRNAGLTTSGFK--------VIHCSGYLKARIYPDR---GDGQGSLIQN 255
              ::||.|||.  :..|..........|        .:||:||:  |.:|.|   .:|:....:.
Zfish   262 --RSFFCRMKYNKITVKEEKDFQAGASKKKESQRYCTVHCTGYM--RTWPTRQLATEGEAEADKE 322

  Fly   256 LG----LVAVG----HSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKT 312
            ..    |||:|    |:|| .|..|||:....|:.|..:|.|..|.|.|.:.:.||.||:|:..:
Zfish   323 SSHFSCLVAMGRVHPHTLP-QANGEIKVKPTEFVTRYAMDGKFTFVDQRATTILGYLPQELLGTS 386

  Fly   313 LYQYIHAADIMAMRCSH-QILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSV 376
            .|:|.|..|:..:...| ::|..|.::.|..|:|.||.|.:|.:||......|..:....:|||.
Zfish   387 CYEYFHLDDLPHLAERHRKVLRSKEKIETNCYKFKTKSGSFVNLQSQWFSFINPWTKEVEYIVST 451

  Fly   377 NYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVV 441
            |.|:|.                |..|.....:|.|.:.:..:...|:.:|          ||.::
Zfish   452 NTVVSG----------------KSNPGGSGDKAEQPSSSKASEDDAKKSQ----------QVPII 490

  Fly   442 PQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNN 506
            |..|.......||..|..:           |:..:|  |.              ..|||.||.|.
Zfish   491 PGISSASGMIYAGCIGTQI-----------ANEIMD--FN--------------RMNSSPSSGNT 528

  Fly   507 NGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSA---GGGSSASASSS 568
            :                    ..|..|...||  .:..:||:|..|.|...   |..||...:..
Zfish   529 S--------------------PFSLLQDKSPL--ALAQASSNVPNGEAKDVEMPGKSSSEEEARG 571

  Fly   569 GVYST 573
            |.:||
Zfish   572 GPFST 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	16/60 (27%)
		PAS	102..215	CDD:395786	39/126 (31%)
		PAS_3	291..377	CDD:430001	28/86 (33%)
bmal2	NP_571653.3	None