Protein Alignment sim and AHRR

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001364165.1
• Gene: AHRR / 57491
• HGNCID: 346
• Length: 697
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 119/501 - (23%)
• Similarity: 190/501 - (37%)
• Gaps: 131/501 - (26%)

  Fly    27 EKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF----------P 81
            ||| |.::..|::.|.|...||.|||.|..|.|:|||.||:||:.|||:::..|          |
Human    28 EKS-NPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQP 91

  Fly    82 DGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNS 146
            .....:.|.|..:...|.::  |..||::|:||..||:.:|.|.|.|.|...:||..|.::...:
Human    92 AAGAPSPGDSCPLAGSAVLE--GRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQN 154

  Fly   147 IFEYIHNYDQDEMNAILSLH-----PHI--NQHPLAQTHTPI-------GSPNGVQHPSAYDHDR 197
            |::|||..|:.:.  ...||     |.:  .|.|..:|....       ....|...|:.|
Human   155 IYDYIHVDDRQDF--CRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEY---- 213

  Fly   198 GSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQ---NLGLV 259
               :..:.:.|..|::|:|.      :||||..:...|.||......:....|:::.   :|..:
Human   214 ---SAFLTRCFICRVRCLLD------STSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCI 269

  Fly   260 AVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMA 324
            |....|||:|  |:|:...:...:.:.|.... .||:|...|.....:|..|..|.        |
Human   270 AAPVLLPSAA--EMKMRSALLRAKPRADTAAT-ADAKVKATTSLCESELHGKPNYS--------A 323

  Fly   325 MRCSHQ--ILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKD 387
            .|.|.:  :|:.:.|         |..|.|..|.:.|.                  .|..|...|
Human   324 GRSSRESGVLVLREQ---------TDAGRWAQVPARAP------------------CLCLRGGPD 361

  Fly   388 LVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQC 452
            |||:. :.|...||                                         ::...:..:.
Human   362 LVLDP-KGGSGDRE-----------------------------------------EEQHRMLSRA 384

  Fly   453 AGATGQPVGPGTPVSLALSASPKLD----PYFEPELPLQPAVTPVP 494
            :|.||:...||....|..:|....:    |..:|.....|::.|:|
Human   385 SGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMP 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	27/68 (40%)
		PAS	102..215	CDD:395786	32/126 (25%)
		PAS_3	291..377	CDD:430001	17/87 (20%)
AHRR	NP_001364165.1	bHLH-PAS_AhRR	26..85	CDD:381441	26/57 (46%)
		PAS	113..176	CDD:214512	22/64 (34%)