DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sim and npas3

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_017207251.1	Gene:	npas3 / 570491	-ID:	-	Length:	979	Species:	Danio rerio

Alignment Length:	797	Identity:	230/797 - (28%)
Similarity:	353/797 - (44%)	Gaps:	231/797 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDG------- 83
            ||||::|||:||.|||.||.||||:|||||||||||||||:||||.||||||.....|
Zfish    91 KEKSRDAARSRRGKENFEFYELAKMLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLR 155

  Fly    84 ------------LGEAWGSSP-AMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHL 135
                        :|.....|| ||........||||:||:||||:|.:..:|:.:|||||.|::|
Zfish   156 IEGPPPNTSVKAIGSQRRRSPNAMASDIFEPHLGSHILQSLDGFVFALNKEGRFLYISETVSIYL 220

  Fly   136 GLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSH 200
            |||||||||:|:|:|:|..|..||...|.:.....:..|:|   ..|:.:|....|:..|.....
Zfish   221 GLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQ---GTGAEDGASSASSSSHSETPE 282

  Fly   201 TIE------------IEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARI-------YPDRG 246
            .:|            :|::||:|||..|.||...:.:||:||||.:|.|:.|:       .|:
Zfish   283 PVESSSPSLLSPDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRIRMALTHSRSVPN-- 345

  Fly   247 DGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEK 311
                   |.:|:|.|.|:||...|.|:::...||:.|..:|:.:::.:.|:|......|.|::.|
Zfish   346 -------QIMGMVVVAHALPPPTINEVRIDCQMFVTRVNMDLNIVYCENRISDYMDLTPVDIVGK 403

  Fly   312 TLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSV 376
            ..|.:|||.|:..:|.||..||.|||..|||||::.|.||::|:||.||:..|::::.|..|:.|
Zfish   404 RCYHFIHAEDVEGIRQSHLDLLNKGQCVTKYYRWIQKNGGYIWIQSSATIAINAKNANEKNIIWV 468

  Fly   377 NYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQA-----------------AQAAQA 424
            |||||..|.||..::      :.:.|..| .:|:::::.:.:                 .:..|:
Zfish   469 NYVLSNPEYKDTPMD------IAQLPNLP-EKASESSETSDSESDSKENSEDNENSKSDGKGNQS 526

  Fly   425 AQAAHVAQA-VQAQVVVVPQQSVVVQPQ------------------------------------- 451
            ::.:...:| .:.|....|:|.:..|.:
Zfish   527 SENSEDPEADSKKQTGRPPEQEMRRQEEGDSSSNPESQDSDDSLEPSDCETDHKEGRLGGLHIKV 591

  Fly   452 -----------------CA----------------GATGQPVGP------------------GTP 465
                             |:                .:.|:..||                  |:.
Zfish   592 EHYGDGEMEGLQDSSSSCSSEDEEEDDVEDIVKDCNSGGELSGPAMSKHQKRKKRRKKQKWDGSR 656

  Fly   466 VSLALSASPKLDP---YFEPELPLQPAVTPVPPTNNSSS------------SSNNNNGVWHH--- 512
            ..|.||.|....|   ..:|.|..||.:. :||:..|||            :.:|::.:|::
Zfish   657 QRLRLSPSAAATPSPGSLDPTLGDQPPLL-LPPSPTSSSVLKIKTEMSEPINFDNDSSIWNYPPN 720

  Fly   513 HHVQQQQQSGSM--DHDSLSYTQLYPPLNDLVVSSSSSV--------GGGTA-------SSAGGG 560
            ..:.:.:...||  .||:..    .||...|.||...||        |||:.       ||:|..
Zfish   721 REISRNESPYSMTKPHDTFP----SPPPAGLQVSIPDSVLTPPGAESGGGSRKPNFNGNSSSGNN 781

  Fly   561 SSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMI----------RPFSANS 615
            ::|:.|.|...|..:..|.::|                 |.|..:..:          .|.|:.|
Zfish   782 NNAATSVSSATSGSLVPPSSST-----------------TADPLSPPLSASPRDKQQGTPTSSGS 829

  Fly   616 NSCSSSSESERQLSTGN 632
            ...:|..|:.::|..||
Zfish   830 LLYTSDLEALQRLQAGN 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	42/51 (82%)
		PAS	102..215	CDD:279347	49/124 (40%)
		PAS	102..163	CDD:214512	35/60 (58%)
		PAS	278..376	CDD:238075	38/97 (39%)
		PAS_3	291..377	CDD:285623	34/85 (40%)
npas3	XP_017207251.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920