Protein Alignment sim and npas3

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_017207251.1
• Gene: npas3 / 570491
• ZFINID: ZDB-GENE-090811-1
• Length: 979
• Species: Danio rerio
• Alignment Length: 797
• Identity: 230/797 - (28%)
• Similarity: 353/797 - (44%)
• Gaps: 231/797 - (28%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDG------- 83
            ||||::|||:||.|||.||.||||:|||||||||||||||:||||.||||||.....|
Zfish    91 KEKSRDAARSRRGKENFEFYELAKMLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLR 155

  Fly    84 ------------LGEAWGSSP-AMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHL 135
                        :|.....|| ||........||||:||:||||:|.:..:|:.:|||||.|::|
Zfish   156 IEGPPPNTSVKAIGSQRRRSPNAMASDIFEPHLGSHILQSLDGFVFALNKEGRFLYISETVSIYL 220

  Fly   136 GLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSH 200
            |||||||||:|:|:|:|..|..||...|.:.....:..|:|   ..|:.:|....|:..|.....
Zfish   221 GLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQ---GTGAEDGASSASSSSHSETPE 282

  Fly   201 TIE------------IEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARI-------YPDRG 246
            .:|            :|::||:|||..|.||...:.:||:||||.:|.|:.|:       .|:
Zfish   283 PVESSSPSLLSPDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRIRMALTHSRSVPN-- 345

  Fly   247 DGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEK 311
                   |.:|:|.|.|:||...|.|:::...||:.|..:|:.:::.:.|:|......|.|::.|
Zfish   346 -------QIMGMVVVAHALPPPTINEVRIDCQMFVTRVNMDLNIVYCENRISDYMDLTPVDIVGK 403

  Fly   312 TLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSV 376
            ..|.:|||.|:..:|.||..||.|||..|||||::.|.||::|:||.||:..|::::.|..|:.|
Zfish   404 RCYHFIHAEDVEGIRQSHLDLLNKGQCVTKYYRWIQKNGGYIWIQSSATIAINAKNANEKNIIWV 468

  Fly   377 NYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQA-----------------AQAAQA 424
            |||||..|.||..::      :.:.|..| .:|:::::.:.:                 .:..|:
Zfish   469 NYVLSNPEYKDTPMD------IAQLPNLP-EKASESSETSDSESDSKENSEDNENSKSDGKGNQS 526

  Fly   425 AQAAHVAQA-VQAQVVVVPQQSVVVQPQ------------------------------------- 451
            ::.:...:| .:.|....|:|.:..|.:
Zfish   527 SENSEDPEADSKKQTGRPPEQEMRRQEEGDSSSNPESQDSDDSLEPSDCETDHKEGRLGGLHIKV 591

  Fly   452 -----------------CA----------------GATGQPVGP------------------GTP 465
                             |:                .:.|:..||                  |:.
Zfish   592 EHYGDGEMEGLQDSSSSCSSEDEEEDDVEDIVKDCNSGGELSGPAMSKHQKRKKRRKKQKWDGSR 656

  Fly   466 VSLALSASPKLDP---YFEPELPLQPAVTPVPPTNNSSS------------SSNNNNGVWHH--- 512
            ..|.||.|....|   ..:|.|..||.:. :||:..|||            :.:|::.:|::
Zfish   657 QRLRLSPSAAATPSPGSLDPTLGDQPPLL-LPPSPTSSSVLKIKTEMSEPINFDNDSSIWNYPPN 720

  Fly   513 HHVQQQQQSGSM--DHDSLSYTQLYPPLNDLVVSSSSSV--------GGGTA-------SSAGGG 560
            ..:.:.:...||  .||:..    .||...|.||...||        |||:.       ||:|..
Zfish   721 REISRNESPYSMTKPHDTFP----SPPPAGLQVSIPDSVLTPPGAESGGGSRKPNFNGNSSSGNN 781

  Fly   561 SSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMI----------RPFSANS 615
            ::|:.|.|...|..:..|.::|                 |.|..:..:          .|.|:.|
Zfish   782 NNAATSVSSATSGSLVPPSSST-----------------TADPLSPPLSASPRDKQQGTPTSSGS 829

  Fly   616 NSCSSSSESERQLSTGN 632
            ...:|..|:.::|..||
Zfish   830 LLYTSDLEALQRLQAGN 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	44/78 (56%)
		PAS	102..215	CDD:395786	49/124 (40%)
		PAS_3	291..377	CDD:430001	34/85 (40%)
npas3	XP_017207251.1	bHLH-PAS_NPAS3_PASD6	86..162	CDD:381575	44/70 (63%)
		PAS	190..248	CDD:214512	33/57 (58%)
		PAS_3	382..469	CDD:430001	34/86 (40%)
		PHA03269	711..>913	CDD:165527	34/157 (22%)