Protein Alignment sim and epas1a

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_695262.7
• Gene: epas1a / 566886
• ZFINID: ZDB-GENE-030131-4490
• Length: 843
• Species: Danio rerio
• Alignment Length: 716
• Identity: 198/716 - (27%)
• Similarity: 310/716 - (43%)
• Gaps: 186/716 - (25%)

  Fly     1 MTNHRRVRKDCYESRLHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKAS 65
            ||..|..::...|.|          ||||::|||.||.||...|.|||..||||.:|:|.|||||
Zfish     1 MTAEREKKRHPSERR----------KEKSRDAARCRRSKETEVFYELAHQLPLPHSISSHLDKAS 55

  Fly    66 VIRLTTSYLKMRQVFPDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISET 130
            ::||..|:|:.|::|..      |.:....|.....::.:..|::|:||:.||..||.::::||.
Zfish    56 IMRLAISFLRTRKLFSS------GQTVQQMRSQNGSQMDNLYLKSLEGFVIVVTSDGDMIFLSEN 114

  Fly   131 ASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDH 195
            .|..:||:||||||:|||::.|..|.:|:...||:           ...|:.|..|.:..::.|
Zfish   115 VSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSI-----------KSGPVYSRKGKEMSTSRD- 167

  Fly   196 DRGSHTIEIEKTFFLRMKCVLAK--RNAGLTTSGFKVIHCSGYLKARIYPDR------GDGQGSL 252
                        ||:||||.:..  |...|.::.:||:||:|:|  ::...|      |..:..|
Zfish   168 ------------FFMRMKCTVTNRGRTVNLKSASWKVLHCTGHL--QVCSSRPPQILCGFSEPPL 218

  Fly   253 IQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYI 317
            .....|.|   .:|..:..:..|....||.|..:|||.|:.|.|||.|.||.|::|:.:::|::.
Zfish   219 TCITMLCA---PIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFC 280

  Fly   318 HAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSE 382
            ||.|...|..|||.|..||||.:..||.|.|.||:|||::.||:::|:|:|:...|:.:||:||.
Zfish   281 HALDSENMTKSHQNLCNKGQVVSGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSS 345

  Fly   383 REVKDLVLNEIQT------------------------------GVVKREPISPAAQAAQAAQAAQ 417
            .|.:.::.:..||                              ..:|.||...|..|.....|..
Zfish   346 VEEQSVIFSLDQTEALFKPYHTYDMGEIFSQNTSISEPQNNLFTTLKEEPEELAQLAPMPGDAII 410

  Fly   418 AA--QAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLD--- 477
            |.  :.|:..:|...:::.:...                     |||...|......||:.:
Zfish   411 ALDFERAEFEEATFFSKSSKLPA---------------------VGPSWVVDTPPDGSPERNLSS 454

  Fly   478 ---PYFEPELP----LQPAVTPVPPTNNSSSSSNN-----NNGVWH----------------HHH 514
               .:..|::|    ..|..||...:.:|.|:.::     .:|.|.                .:.
Zfish   455 LPSSFTVPQVPPAGKCTPCTTPCLSSCSSCSTPSSPVDCCGSGEWDLKVELTEKLFASESGATNP 519

  Fly   515 VQQQQQSGSMDHDSLS-YT-------QLYP-----PLNDLVVSSSSSVGGGTASSAGGGSSAS-- 564
            ...|.....:|.::|: |.       ||:|     |:.|                ||.|.||:
Zfish   520 TDSQLNLSDLDLETLAPYIPMDGEDFQLHPICLEEPVPD----------------AGPGLSAAVQ 568

  Fly   565 ---ASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESER 626
               :|.:.::....|||.       ||.|.      .:|...||. |:|:....| ...|||.:|
Zfish   569 HSFSSVADLFQPLGQYPP-------YNKNR------PSTCPDATH-IQPYQTTPN-IPLSSEKQR 618

  Fly   627 Q 627
            |
Zfish   619 Q 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	32/60 (53%)
		PAS	102..215	CDD:395786	36/112 (32%)
		PAS_3	291..377	CDD:430001	38/85 (45%)
epas1a	XP_695262.7	None