Protein Alignment sim and sim1b

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001153057.1
• Gene: sim1b / 566656
• ZFINID: ZDB-GENE-041210-5
• Length: 586
• Species: Danio rerio
• Alignment Length: 666
• Identity: 299/666 - (44%)
• Similarity: 369/666 - (55%)
• Gaps: 115/666 - (17%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWG 89
            ||||||.||||||||||:||.||||:||||:||||||||||:||||:||||||.|||.||||.||
Zfish     1 MKEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMRLVFPQGLGEVWG 65

  Fly    90 SSPAMQRGAT-IKELGSHL--------LQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 145
            .:...:.|.. ..||||||        ||||||||||||.|||||||||||||||||||||||||
Zfish    66 QAGRTRSGENPSHELGSHLLQVIISKMLQTLDGFIFVVAADGKIMYISETASVHLGLSQVELTGN 130

  Fly   146 SIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFL 210
            ||:||:|..|.|||.|:|:..|..:.|.:.:                         .|:|::|||
Zfish   131 SIYEYVHPADHDEMAAVLTPQPSYHSHFVQE-------------------------YEVERSFFL 170

  Fly   211 RMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKL 275
            ||||||||||||||:.|:||||||||||.|.:...........||:|||||||:||.||:|||||
Zfish   171 RMKCVLAKRNAGLTSGGYKVIHCSGYLKIRQFSLDASPFDGCYQNVGLVAVGHTLPPSAVTEIKL 235

  Fly   276 HQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTT 340
            |.|||||||.|||||||.|:|||.|||||||||||||||.::|..|...:||:|.:||.||||||
Zfish   236 HSNMFMFRASLDMKLIFLDSRVSDLTGYEPQDLIEKTLYHHVHCCDSFHLRCAHHLLLVKGQVTT 300

  Fly   341 KYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISP 405
            ||||||:|.|||||||||||:||||||||...||||||||::.|.|.|:|:..|.     .|..|
Zfish   301 KYYRFLSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQL-----NPRKP 360

  Fly   406 AAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQS-------VVVQPQCAGATGQPVGPG 463
            |...|..:.......:......:|.:|...:   ..|.:|       ....|....|:.|.:...
Zfish   361 AFPYANHSDKTHTTNSRSKILLSHYSQQFSS---FPPDRSDSDHDSQWEDSPLTDSASPQRLDRS 422

  Fly   464 TPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVW-------HHHHVQQQQQS 521
            ..|..:|:.|..:....:...||                 .|.:|.|       |.|.|
Zfish   423 DSVCFSLAQSDVMQSCSQTHTPL-----------------FNRDGWWDARAANQHSHAV------ 464

  Fly   522 GSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLY 586
              .|.|               :||||      |.||.|..|...::..:...|..:....:.:..
Zfish   465 --WDED---------------LSSSS------AQSADGAQSLIRAAPELIKVEEAHMRDYSSSSL 506

  Fly   587 YNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASI-VNETSPSQTTYS--- 647
            :::..|...|.|.:         |.|.::.|...|....:.||....:: ...|.||...||
Zfish   507 FSSARHRDGDPDGS---------PASLSALSSPGSDRPSQPLSASPPALETTHTHPSLRAYSAHY 562

  Fly   648 DLSHNFELSYFSDNSS 663
            |::.:|:.|..:.|.:
Zfish   563 DINTHFQSSTTAHNGT 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	51/60 (85%)
		PAS	102..215	CDD:395786	64/120 (53%)
		PAS_3	291..377	CDD:430001	63/85 (74%)
sim1b	NP_001153057.1	bHLH-PAS_SIM1	1..70	CDD:381581	55/68 (81%)
		PAS	92..148	CDD:214512	47/55 (85%)
		PAS_11	99..205	CDD:464214	75/130 (58%)
		PAS_3	251..337	CDD:430001	63/85 (74%)
		SIM_C	357..>498	CDD:461963	34/189 (18%)