Protein Alignment sim and Hif3a

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001156422.1
• Gene: Hif3a / 53417
• MGIID: 1859778
• Length: 664
• Species: Mus musculus
• Alignment Length: 568
• Identity: 170/568 - (29%)
• Similarity: 260/568 - (45%)
• Gaps: 122/568 - (21%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||:||.:|.....:||..||....:::.|||||::|||.|||:|.::...|   .|..
Mouse    16 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG---EWNQ 77

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYD 155
               :::|.  :.|.:..|:.|:||:.|:..:|.:.|:||..|.||||||:||.|:|||::||..|
Mouse    78 ---VEKGG--EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCD 137

  Fly   156 QDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK-- 218
            |:|:...|:..|::::..|             :.|:             |:.|.||||..|..
Mouse   138 QEELQDALTPRPNLSKKKL-------------EAPT-------------ERHFSLRMKSTLTSRG 176

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGS-----LIQNLGLVAVGHSLPSSAITEIKLHQN 278
            |...|..:.:||:||||:::|...|.:....||     .:|.|.|:.  .::|..|..|..|.:.
Mouse   177 RTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLIC--EAIPHPASLEPPLGRG 239

  Fly   279 MFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYY 343
            .|:.|..||||..:.|.|::::.||.|.|||..:.|:||||.|..|:..|...||.|||..|..|
Mouse   240 AFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQY 304

  Fly   344 RFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQ 408
            |||.:.||::|.|:.||:|...|..:...|:.|::::|..|...:||:..||....|.|
Mouse   305 RFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEETGVVLSLEQTEQHTRRP------ 363

  Fly   409 AAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSAS 473
                                             |:.|...|   .|..|..|....|..||....
Mouse   364 ---------------------------------PRLSASSQ---KGIPGNSVDSPAPRILAFLHP 392

  Fly   474 PKL-------DP--YFEPEL-----PL----QPAVTPVPPTNNSSSSS--------NNNNGVWHH 512
            |.|       ||  :..|:|     |:    .||.||..|.......|        ....|:.:.
Mouse   393 PALSEASLAADPRRFCSPDLRRLMAPILDGPPPAATPSTPQATRRPQSPLPADLPDKLTVGLENA 457

  Fly   513 HHVQQQQQSGSM--------DHDSLSYTQLYPPL---NDLVVSSSSSV 549
            |.:...|::.::        |.|:|....|.|.:   :|..::||..:
Mouse   458 HRLSTAQKNKTVETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	27/59 (46%)
		PAS	102..215	CDD:395786	38/112 (34%)
		PAS_3	291..377	CDD:430001	35/85 (41%)
Hif3a	NP_001156422.1	bHLH-PAS_HIF3a_PASD7	12..74	CDD:381572	27/60 (45%)
		PAS	90..145	CDD:214512	27/54 (50%)
		PAS_3	251..338	CDD:430001	35/86 (41%)
		HIF-1	475..506	CDD:463274	8/31 (26%)