Protein Alignment sim and hif1a

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001011165.2
• Gene: hif1a / 496583
• XenbaseID: XB-GENE-946622
• Length: 796
• Species: Xenopus tropicalis
• Alignment Length: 668
• Identity: 188/668 - (28%)
• Similarity: 307/668 - (45%)
• Gaps: 140/668 - (20%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            ||||::|||.||.||:..|.||:..||||..::|.|||||::|||.|||::|::.  ..|:..|.
 Frog    19 KEKSRDAARCRRSKESEVFYELSHELPLPHNVSSHLDKASIMRLTISYLRIRRLL--DAGDLDGE 81

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYD 155
            :      ...|:|....|:.|:||:.|:..:|.::|:||..:..:||:|.||||:|:|::.|..|
 Frog    82 T------ELDKQLNCFYLKALEGFVLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCD 140

  Fly   156 QDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK-- 218
            .:|:..:|:..                  ||   |:    .:|...| .|::|||||||.|..
 Frog   141 HEELREMLTFR------------------NG---PA----KKGKEQI-TERSFFLRMKCTLTSRG 179

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLG--------LVAVGHSLPSSAITEIKL 275
            |...:.::.:||:||:|::  |:|.....      .:.|        :|.:...:|..:..|..|
 Frog   180 RTVNIKSATWKVLHCTGHM--RVYDANNH------NHCGYKKPPMTCMVIICEPIPHPSNIEFPL 236

  Fly   276 HQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTT 340
            ....|:.|..||||..:.|.||::|.||||.:|:.:::|:|.||.|...:..:|..:..||||||
 Frog   237 DSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKAHHNMFTKGQVTT 301

  Fly   341 KYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISP 405
            ..||.|.|.||:|||::.||:::||::|:...||.|||||||...|||:|:..||..|    :||
 Frog   302 GQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTACV----LSP 362

  Fly   406 AAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLAL 470
            .     .:|..:..:........:.|:.:..::...|:...|:.|.    .|..:     :||..
 Frog   363 V-----ESQEMKMPEIFTELNEDNNAECLFEKLKQEPESLTVLAPD----AGDEI-----ISLDF 413

  Fly   471 SASPKLDPYFEPELPL--------------QPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQS 521
            |:.....||  .::||              ...|||:|.:.......:|.:...:...|.:.:.:
 Frog   414 SSGDSDKPY--EDVPLYNDVMLHSTSKKLESTPVTPLPASEMPKPLRSNVDPALNREVVIKMESN 476

  Fly   522 GSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLY 586
            ......:.:..||..|.:...:|||.|                       |||...|.
 Frog   477 PEQLELTFTIPQLSKPDSPSDISSSQS-----------------------STEPSTPP------- 511

  Fly   587 YNNNNHYYYDYDATV------DVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTT 645
                 .|.:|.|:.:      |:...:   |:.::.:.:..|..|..|.      :...:|
 Frog   512 -----EYCFDVDSEIASEFKLDLVEKL---FAIDTEAKAPFSTQETDLD------LEMLAP---- 558

  Fly   646 YSDLSHNFELSYFSDNSS 663
            |..:..:|:|..|...||
 Frog   559 YIPMDDDFQLRTFDQLSS 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	31/59 (53%)
		PAS	102..215	CDD:395786	35/112 (31%)
		PAS_3	291..377	CDD:430001	37/85 (44%)
hif1a	NP_001011165.2	bHLH-PAS_HIF1a_PASD8	13..83	CDD:381570	33/71 (46%)
		PAS	93..148	CDD:214512	21/54 (39%)
		PAS_3	253..338	CDD:430001	37/84 (44%)
		HIF-1	545..575	CDD:463274	8/39 (21%)
		HIF-1a_CTAD	761..795	CDD:430212