Protein Alignment sim and arnt

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001428910.1
• Gene: arnt / 493634
• ZFINID: ZDB-GENE-060126-7
• Length: 747
• Species: Danio rerio
• Alignment Length: 728
• Identity: 166/728 - (22%)
• Similarity: 285/728 - (39%)
• Gaps: 147/728 - (20%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::|..:    |.|.....
Zfish    65 RENHSEIERRRRNKMTAYITELSDMVPACSALARKPDKLTILRMAVSHMKSLR----GTGNTSTD 125

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154
            ........|.:||...:|:..|||:|||:.: |:::|:|::.:..|..:|.:..|:|:::.:|..
Zfish   126 GTYKPSFLTDQELKHLILEAADGFLFVVSCETGRVVYVSDSVTPVLNQAQSDWLGSSLYDQLHPD 190

  Fly   155 DQDEMNAILS-LHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEI----EKTFFLRMKC 214
            |.:::...|| ...:.|...:....|......|           |..|:.:    .::|..||:|
Zfish   191 DVEKLREQLSTTENNNNSGRMLDMKTGTVKKEG-----------GQATVRMSMGARRSFICRMRC 244

  Fly   215 --------------VLAKRN---AGLTTSG---FKVIHCSGYLKARIYPDRG---------DGQG 250
                          .|..||   .|....|   :.|:||:||:  |.:|..|         :.||
Zfish   245 GVCPVEPVSLNRLNFLRTRNRNGLGSAKDGEQQYVVVHCTGYI--RSWPPAGMNLSEEEADNNQG 307

  Fly   251 SLIQNLGLVAVGH----SLPS-SAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIE 310
            :   ...|||:|.    ..|| ::|..|.:... |:.|........|.|.|.:...|::.|:|:.
Zfish   308 N---RFCLVAIGRLQVTCCPSDTSINNISVPVE-FISRHNSQGVYTFVDHRCTATVGFQTQELLG 368

  Fly   311 KTLYQYIHAADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIV 374
            |.:..:.|..|...:|.| .|::..:|||.:..:||.:|...|||:::.:....|..|....:|:
Zfish   369 KNILDFAHPEDQGLLRDSLQQVVKLRGQVMSVMFRFQSKSREWVWMRTSSFTFQNPFSEEIEYII 433

  Fly   375 ----SVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAV- 434
                :||...||..|..|     .:..:.:.|..|:..:.......|..|.........::|..
Zfish   434 CTNTNVNRGSSEGSVSPL-----SSPSLGQSPNCPSTPSPGCVTVRQLQQQQVELDGGGMSQETP 493

  Fly   435 -QAQVVVVPQQSVVVQPQCAG---------------ATGQPVGPGTPVSLALSASPKLDPYFEPE 483
             :...|.:||.||    |..|               ::||.|.|  |.:...|.:...:.:..|.
Zfish   494 YENSQVALPQVSV----QTCGVVSADHSSKAVSSSVSSGQQVYP--PAAAFPSPARPTETFRSPV 552

  Fly   484 LPLQPAVTPV-------------PPTNNSSSSSNNN-----------NGVWH--HHHVQQQQQSG 522
            ||.|  :.||             ..|.:..|.|||:           .|:|:  ......||.:|
Zfish   553 LPQQ--MVPVAHSAGQMLAQMSRQSTPSGVSGSNNSPIQAPSGPTAPPGLWNTTRQPFSTQQVAG 615

  Fly   523 SMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAG--GGSSASASSSGVYSTEMQYPDTTTGNL 585
            .:..:..:      |.|  :...||:....|:||.|  ||:|||.:|:..|.....:.:.:|..
Zfish   616 PIGKNQSA------PFN--MGGFSSASAPSTSSSFGQMGGASASMASTSSYQQINSHSNPSTNG- 671

  Fly   586 YYNNNNHYYYDYDATVDVATSM-IRPFSANSNSCSSSSESERQLSTGNASIVNETS--PSQTTYS 647
                       |.....:|.:. .||....:......|::..|.|.......|:|.  |...:..
Zfish   672 -----------YGDVGQIAAAFGTRPAEGVTGWQQWPSQTHTQASADTQVQNNQTDMFPDVLSML 725

  Fly   648 DLSHNFELSYFSD 660
            |.|.:|....||:
Zfish   726 DQSGSFSNGDFSE 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	15/59 (25%)
		PAS	102..215	CDD:395786	29/132 (22%)
		PAS_3	291..377	CDD:430001	24/90 (27%)
arnt	NP_001428910.1	None