Protein Alignment sim and NPAS2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_054198248.1
• Gene: NPAS2 / 4862
• HGNCID: 7895
• Length: 889
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 158/745 - (21%)
• Similarity: 281/745 - (37%)
• Gaps: 162/745 - (21%)

  Fly     8 RKDCYESRLHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTS 72
            ||:|.|:.:.:..|..|.:.....:.:.||::.|....||:.:||   ..|.::||.:|:.....
Human    58 RKNCIENLMDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIG 119

  Fly    73 YL-KMRQVFPD----GLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETAS 132
            :| |..:|...    .:.:.|  .|:........:|   :|:.|||||..|..||.|:|:|::.:
Human   120 FLQKHNEVSAQTEICDIQQDW--KPSFLSNEEFTQL---MLEALDGFIIAVTTDGSIIYVSDSIT 179

  Fly   133 VHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQ-----------THTPIGSPNG 186
            ..||....::...::..::...:..|:..|||.|..:...|..:           .|...||.|.
Human   180 PLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNP 244

  Fly   187 VQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGS 251
            .:.|: |::                :|.|...|:.....|.    .|:|:......|.|.. .|.
Human   245 KEFPT-YEY----------------IKFVGNFRSYNNVPSP----SCNGFDNTLSRPCRVP-LGK 287

  Fly   252 LIQNLGLV--AVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLY 314
            .:..:..|  |....|....|.:..|.:  |..|..|:.|.:|.|.|...:.||.|.:::..:.|
Human   288 EVCFIATVRLATPQFLKEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGY 350

  Fly   315 QYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYV 379
            .|.|..|:..:...||.|:..|:..:..|||||||..|:|:|::..:.::..:|:..|||..:.|
Human   351 DYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSV 415

  Fly   380 LSEREVK-----DLVLNEIQTGVVKREPISPAAQAAQAAQ---------------AAQAAQAAQA 424
            :|..:|:     :|.|.:..:..:....:.....:.:..|               .:.:|.:..:
Human   416 VSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSS 480

  Fly   425 AQAAHVAQA----------VQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPY 479
            .:::|.|.:          .:|....:|:.:.:  ||.....|.......|..|...:|..|...
Human   481 HKSSHTAMSEPTSTPTKLMAEASTPALPRSATL--PQELPVPGLSQAATMPAPLPSPSSCDLTQQ 543

  Fly   480 FEPELPLQPAVTPVPPTNNSSSSSN---------------NNNGVWHHHHVQQQQQSGSMDHDSL 529
            ..|:..||.  ||.|....|:..|.               ..|..|....:.:.|:...:..||.
Human   544 LLPQTVLQS--TPAPMAQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCLVQDSN 606

  Fly   530 SYTQLYPPLNDLVVSS-------------SSSVGGGTASSAGGG-------SSASASS------S 568
            ....|..|...|..||             |::|   |....|.|       |||..:|      |
Human   607 VQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAV---TQPQLGAGPQLPGQISSAQVTSQHLLRES 668

  Fly   569 GVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNA 633
            .|.||:...|..::..:..:..:            .:|::.|||:.:.:...|
Human   669 SVISTQGPKPMRSSQLMQSSGRS------------GSSLVSPFSSATAALPPS------------ 709

  Fly   634 SIVNETSPSQTTYS--------DLSHNFEL 655
              :|.|:|:.|:..        |.||:.:|
Human   710 --LNLTTPASTSQDASQCQPSPDFSHDRQL 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	14/65 (22%)
		PAS	102..215	CDD:395786	28/123 (23%)
		PAS_3	291..377	CDD:430001	28/85 (33%)
NPAS2	XP_054198248.1	bHLH-PAS_NPAS2_PASD4	66..142	CDD:381580	17/80 (21%)
		PAS	149..260	CDD:395786	29/130 (22%)
		PAS_11	314..417	CDD:464214	33/104 (32%)
		Atrophin-1	628..>823	CDD:460830	27/139 (19%)