DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sim and NPAS1

DIOPT Version :9

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_002508.2 Gene:NPAS1 / 4861 HGNCID:7894 Length:590 Species:Homo sapiens


Alignment Length:568 Identity:199/568 - (35%)
Similarity:278/568 - (48%) Gaps:127/568 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF-----PDGL- 84
            ||||:||||:||.|||.||.|||||||||.||:|||||||::||:.:||::|:..     |.|| 
Human    47 KEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLR 111

  Fly    85 --GEAWGSSPAMQRGATI------KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVE 141
              |...|.:|..:..|.:      :.||.|:||:||||:|.:..:||.:|||||.|::|||||||
Human   112 AAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVE 176

  Fly   142 LTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTI---- 202
            :||:|:|:|||..|..|:...|.|          :|.|| |.|.   .||.......|.::    
Human   177 MTGSSVFDYIHPGDHSEVLEQLGL----------RTPTP-GPPT---PPSVSSSSSSSSSLADTP 227

  Fly   203 EI--------------EKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLI 253
            ||              |::||:|||..|.||...:..||:||||.:|.|:|..            
Human   228 EIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHA------------ 280

  Fly   254 QNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIH 318
              |||||:||:||.:.:.|:.||.:|.:||..|.:.::..::|||......|.:|:.::.||::|
Human   281 --LGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDLGPSELVGRSCYQFVH 343

  Fly   319 AADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSER 383
            ..|...:|.||..||.||||.|.|||:|.:.||:||:||.||:..:.:|..|..::.|::|||:.
Human   344 GQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATVAGSGKSPGEHHVLWVSHVLSQA 408

  Fly   384 EVKDLVLNEIQ--TGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQ-- 444
            |.....|:..|  ..|...|..||..:..:.....:..|||.|...|...|..:.:|...|::  
Human   409 EGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGKQAAPAENEAPQTQGKRIKVEPGPRETK 473

  Fly   445 ----------------------SVV---------VQPQCAGATGQP-----------------VG 461
                                  ||:         |:|......|.|                 ..
Human   474 GSEDSGDEDPSSHPATPRPEFTSVIRAGVLKQDPVRPWGLAPPGDPPPTLLHAGFLPPVVRGLCT 538

  Fly   462 PGT----PVSLA--------LSASPKLDPYFEPELPLQ---PAVTPVP 494
            |||    |..|.        |...|.|...|.|.|.|.   ||.|.:|
Human   539 PGTIRYGPAELGLVYPHLQRLGPGPALPEAFYPPLGLPYPGPAGTRLP 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 HLH 26..78 CDD:238036 37/51 (73%)
PAS 102..215 CDD:279347 52/130 (40%)
PAS 102..163 CDD:214512 34/60 (57%)
PAS 278..376 CDD:238075 37/97 (38%)
PAS_3 291..377 CDD:285623 33/85 (39%)
NPAS1NP_002508.2 HLH 45..96 CDD:238036 36/48 (75%)
PAS 141..198 CDD:214512 32/56 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 10/44 (23%)
PAS_3 315..386 CDD:312074 30/70 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..494 11/68 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3558
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D393498at33208
OrthoFinder 1 1.000 - - FOG0000232
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2563
SonicParanoid 1 1.000 - - X501
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

Return to query results.
Submit another query.