DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and sima

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster

Alignment Length:	803	Identity:	210/803 - (26%)
Similarity:	326/803 - (40%)	Gaps:	220/803 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF 80
            :.|.......||||::|||.||.||...|.||:..|||.....:|||||||:|:|.::||:|::.
  Fly   150 IEDFMNNEKRKEKSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREML 214

  Fly    81 P---------DGLGEAWGSSPAMQ--------------RGATIKELGSHLLQTLDGFIFVVAPDG 122
            .         |.:.:...::...|              .||..:||   |.||:|||:.|::.:|
  Fly   215 QFVPSLRDCNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEAREL---LKQTMDGFLLVLSHEG 276

  Fly   123 KIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGV 187
            .|.|:||....:||:::::..|..|:||.|..|..|:...|||...:.|....:..
  Fly   277 DITYVSENVVEYLGITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQ--------- 332

  Fly   188 QHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK--RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQG 250
            |:.....|.|         ..|:|:||.|..  |:..:.::.:||||.:|:|..       :.:|
  Fly   333 QNSGVSTHHR---------DLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVV-------NAKG 381

  Fly   251 SLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQ 315
            ..:    |:|:|..:|..:..||.|..:.|:.:..|||:..:.|.::..|.||.|:||::.:|:.
  Fly   382 ERL----LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFS 442

  Fly   316 YIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVL 380
            ..|.||...:..:.:.:|.|||..|..||||.|.||:.|:.|.||:|::....:.|  |.||||:
  Fly   443 CQHGADSERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSV--VCVNYVI 505

  Fly   381 SEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQ-------AAQAAHVAQ------ 432
            |..|             .|.|..|.|.|.|.:.|..|..|||:       ||....:||
  Fly   506 SNLE-------------NKHEIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETV 557

  Fly   433 -------AVQAQVVVVPQQS-----------VVVQPQCAGATGQPV------------------- 460
                   .:||:.:.:..:.           ..:.|..|.:|...:
  Fly   558 NTPIHTSELQAKPLQLESEKAEKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLI 622

  Fly   461 -------GPGTPVSLALSAS----------PK------LDPYFEPELPLQPAVTPV--------- 493
                   ||.|..:..||.|          ||      |.|  .|..||.|..|.|
  Fly   623 KRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRP--SPAPPLTPPPTAVLCKKTPLGV 685

  Fly   494 ----PPTNNSS----SSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVG 550
                |||..::    ||||....:.....:|..||                |..|:
  Fly   686 EPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQ----------------PAQDM--------- 725

  Fly   551 GGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYD-----YDATVDVATSMIRP 610
                  :.|..|..|......:...:.||..:.:|  .:.|....|     .|..|.:..:.:.|
  Fly   726 ------SKGFCSLFADDGRGLTMLKEEPDDLSHHL--ASTNCIQLDEMTPFSDMLVGLMGTCLLP 782

  Fly   611 FSAN---SNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSH-NFELSYFSDNSS-------- 663
            ...|   |.:||:::..:...|..::|   .::||.|:.|:.|: |..||..:.||:
  Fly   783 EDINSLDSTTCSTTASGQHYQSPSSSS---TSAPSNTSSSNNSYANSPLSPLTPNSTATASNPSH 844

  Fly   664 ---QQHQHQQQQQHLMEQQHLQY 683
               |||.:|||||...:|.|.|:
  Fly   845 QQQQQHHNQQQQQQQQQQHHPQH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	28/51 (55%)
		PAS	102..215	CDD:279347	33/112 (29%)
		PAS	102..163	CDD:214512	23/60 (38%)
		PAS	278..376	CDD:238075	34/97 (35%)
		PAS_3	291..377	CDD:285623	30/85 (35%)
sima	NP_001287599.1	HLH	156..209	CDD:238036	26/52 (50%)
		PAS	256..392	CDD:279347	46/167 (28%)
		PAS	265..>317	CDD:238075	18/51 (35%)
		PAS	404..505	CDD:238075	37/102 (36%)
		PAS_3	417..502	CDD:285623	30/86 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I7753
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm14250
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020