DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and dysf

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_733137.3	Gene:	dysf / 43174	FlyBaseID:	FBgn0039411	Length:	920	Species:	Drosophila melanogaster

Alignment Length:	825	Identity:	162/825 - (19%)
Similarity:	268/825 - (32%)	Gaps:	278/825 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLK----MRQVFPDGLGEA 87
            :.:|.|::.||:..|.|...|..|||||.:...:|.:..::.|...|::    .:|||     :.
  Fly   155 KSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVF-----KR 214

  Fly    88 WGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT--GNSIFEY 150
            ..:...:........:|  ..:.|.||:.::..:||::|||:.|:.:||.|..:|.  |:|:::.
  Fly   215 HNAMHHLHHQTATPNIG--FSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDI 277

  Fly   151 IHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGS----------HTIEIE 205
            |..  ||..|....|:.::...|...:....|...|...........||          .::|.|
  Fly   278 IDK--QDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGE 340

  Fly   206 KTFFL-RMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGH------ 263
            ...|| ||.   ..||                  ||.....||.:..|:|       ||
  Fly   341 HRMFLCRMN---VSRN------------------ARRQMRFGDQKVVLVQ-------GHYLSFLP 377

  Fly   264 ----------------SLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKT 312
                            ::|.:....::...|:|.....:|||:...|.......||:...|...:
  Fly   378 LCSRNEPVFLATCTPIAMPETRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTS 442

  Fly   313 LYQYIHAADIMAMRCSHQILLYKGQVTT--KYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVS 375
            .|..||:.::...:..|.:::...|..:  ...|.....|.:.||.....:..:..|:::..||.
  Fly   443 WYNLIHSDNLTEAQKKHSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVC 507

  Fly   376 VNYVLSEREVKDLVLN-----------EIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAH 429
            .|.||::||...::.|           :||.|:    |:.
  Fly   508 TNQVLNDREASIMLANSWLYHYYTVQSKIQFGM----PLD------------------------- 543

  Fly   430 VAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVP 494
                                      :|..|.||||.|          .|:.|.....|| ||..
  Fly   544 --------------------------SGIRVPPGTPSS----------GYYSPHSSHPPA-TPGG 571

  Fly   495 PTNNSSSSS--------NNNNGVWHHHHVQQQQQS----------GSMDH--------------- 526
            .|.|...:|        ::::...||||......:          |.:.|
  Fly   572 ATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKAAIELKEDQPLFC 636

  Fly   527 --DSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSS-----------ASASSSGVYSTEMQYP 578
              :.:.|:|:...:|....:|:.:.....:|:......           |..|.:...:.|   |
  Fly   637 FQEPVDYSQVNSHVNPPNATSTPNPPISKSSTPPPPKKRARKLEPLYLHAERSPAAAITPE---P 698

  Fly   579 DTTTGNLYYNNNNHYYYDY--------DATVDVATSM-IRP-------------FSANSNSCSSS 621
            |.      |..:.|....|        ||:|..||.: .||             |....|.....
  Fly   699 DC------YAIHTHPAAAYATSSVVSSDASVIYATIVPTRPRLPNKSLPPDPADFIEQWNPSPPW 757

  Fly   622 SESERQLSTGNASIVNETSPSQTT-----YSDLSHN------------FELSYFSD--------- 660
            |||.::.|..:....:|.||..||     .|...|.            |...:.||
  Fly   758 SESAQKASLDSFGSSHELSPCITTTPPTPTSATPHQSGLGTTQTIGPAFSFEWMSDPLVPVTYQQ 822

  Fly   661 ---------------NSSQQHQH---QQQQQHLM--EQQHLQYQY 685
                           :.||.||:   |||.:.|:  :|.||..|:
  Fly   823 WPPTGDHHQHLSQHLSQSQNHQNPLQQQQNEQLLLGQQPHLHQQH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	15/54 (28%)
		PAS	102..215	CDD:279347	32/125 (26%)
		PAS	102..163	CDD:214512	20/62 (32%)
		PAS	278..376	CDD:238075	21/99 (21%)
		PAS_3	291..377	CDD:285623	16/87 (18%)
dysf	NP_733137.3	PAS	235..292	CDD:214512	20/58 (34%)
		PAS	407..506	CDD:238075	19/98 (19%)
		PAS_11	408..517	CDD:291273	25/108 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010