Protein Alignment sim and ARNT

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001659.1
• Gene: ARNT / 405
• HGNCID: 700
• Length: 789
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 176/765 - (23%)
• Similarity: 282/765 - (36%)
• Gaps: 168/765 - (21%)

  Fly     1 MTN--HRRVRKDCYESRLHDIAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDK 63
            |:|  .|..|.|..:|   ...|....:|......|.||.|......||:.::|..:|:..:.||
Human    67 MSNDKERFARSDDEQS---SADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDK 128

  Fly    64 ASVIRLTTSYLKMRQVFPDGLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYI 127
            .:::|:..|::|..:    |.|.............|.:||...:|:..|||:|:|:.: |:::|:
Human   129 LTILRMAVSHMKSLR----GTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYV 189

  Fly   128 SETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSA 192
            |::.:..|...|.|..|:::::.:|..|.|::...||...:.....:....|......|.|  |:
Human   190 SDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQ--SS 252

  Fly   193 YDHDRGSH---------------TIEIEKTFFLRMKCVLAKRNAGLTTSG---FKVIHCSGYLKA 239
            .....||.               .:.:.:..|:|.:|   :...|....|   |.|:||:||:||
Human   253 MRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRC---RNGLGSVKDGEPHFVVVHCTGYIKA 314

  Fly   240 RIYPDRG---------DGQGSLIQNLGLVAVGH----SLPSSAITEIKLHQNMFMFRAKLDMKLI 291
              :|..|         .||||   ...|||:|.    |.|:............|:.|..::....
Human   315 --WPPAGVSLPDDDPEAGQGS---KFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFT 374

  Fly   292 FFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWV 355
            |.|.|.....||:||:|:.|.:.::.|..|...:|.| .|::..||||.:..:||.:|...|:|:
Human   375 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWM 439

  Fly   356 QSYATLVHNSRSSREVFIV--SVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQA 418
            ::.:....|..|....:|:  :.|...|.:|.:..:.|.||     |..:.|.|.......:.|.
Human   440 RTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQ-----RPQLGPTANLPLEMGSGQL 499

  Fly   419 AQAAQAAQAAHVAQAVQAQVVVVP--------QQSVVVQPQCAGATGQPVGPGTPVSLALSASPK 475
            |...|..         |.::.:||        ..|.||||  ...||.........|..|.|..:
Human   500 APRQQQQ---------QTELDMVPGRDGLASYNHSQVVQP--VTTTGPEHSKPLEKSDGLFAQDR 553

  Fly   476 LDPYF---------EPELPLQPAVTPV-----------PPTNNSSSSSNNNNGVWHHHHVQQQQQ 520
             ||.|         :....:..:..|.           |||...:.:..|:.
Human   554 -DPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSG------------- 604

  Fly   521 SGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEMQYPDTTTGNL 585
                         |.||:.  :|..|:|.|...|..    |..|..:.|  :|....|.|.:|
Human   605 -------------LAPPVT--IVQPSASAGQMLAQI----SRHSNPTQG--ATPTWTPTTRSG-- 646

  Fly   586 YYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLS 650
                   :.....||...|.:....|...|....||..|   :|...|.   ..||....|..|:
Human   647 -------FSAQQVATQATAKTRTSQFGVGSFQTPSSFSS---MSLPGAP---TASPGAAAYPSLT 698

  Fly   651 HNFELSYFSDNSSQQ---------------HQHQQQQQH---LMEQQHLQ 682
            :..  |.|:..:.|.               .|.|.||.|   ...:||:|
Human   699 NRG--SNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQ 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	15/60 (25%)
		PAS	102..215	CDD:395786	28/128 (22%)
		PAS_3	291..377	CDD:430001	26/88 (30%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..97		8/32 (25%)
		bHLH-PAS_ARNT	86..150	CDD:381517	17/67 (25%)
		DNA-binding. /evidence=ECO:0000269|PubMed:28396409	88..128		9/39 (23%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762	112..264		37/157 (24%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762	112..168		13/59 (22%)
		PAS	163..269	CDD:395786	26/107 (24%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762	167..171		1/3 (33%)
		PAS_11	362..462	CDD:464214	28/99 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..492		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..789		20/83 (24%)