DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and hif1al

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_005157628.2	Gene:	hif1al / 393376	ZFINID:	ZDB-GENE-040426-1315	Length:	626	Species:	Danio rerio

Alignment Length:	557	Identity:	158/557 - (28%)
Similarity:	253/557 - (45%)	Gaps:	86/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            |.:|::|||.||.:|...|.|||..||||..|.|.||||:::|:|.|||:|.::...|
Zfish    15 KVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSG------- 72

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYD 155
            |...|...:.........|.|.|||.|:..:|.::::||:.|.::|::|:||.|.|::|::|..|
Zfish    73 STKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCD 137

  Fly   156 QDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK-- 218
            |:|:..||:..|                  ||......:|:           ||||||..|..
Zfish   138 QEELRDILATRP------------------GVSKKKTMEHN-----------FFLRMKSTLTHTG 173

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFR 283
            |...:.::.:||:||:|:::    |..||.:.|......|..:...:|..:..|..|..:.|:.|
Zfish   174 RTVNIKSATWKVLHCTGHMQ----PFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTR 234

  Fly   284 AKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTK 348
            ..||:.....|.||::|.||:|.|||.::.:::.||.|...:..|..||..||||.|..||||.|
Zfish   235 HNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAK 299

  Fly   349 GGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAA 413
            .||:||.::.||:::|||:|:...:|.:|::||..|.:|:|.:..||    .|...|..:.....
Zfish   300 NGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQT----CEKPKPKVERLMVL 360

  Fly   414 QAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPK--- 475
            :..|.....:.:..|.:.    .|:...|::.:.:.|. :|.....:..|..:|.....||.
Zfish   361 KEEQEDSDMEESSTAKLF----LQMKENPEELLQLAPH-SGDAIISLTEGLELSFCCPQSPNSVP 420

  Fly   476 --------------LDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNGVWHHHHVQQQQQSG---- 522
                          |.|.|:......||.:|................:.....:..:.||.
Zfish   421 ECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDE 485

  Fly   523 ----------SMDHD----SLSYTQLYPPLNDLVVSS 545
                      |||.|    .|..:::.|||..|..:|
Zfish   486 LDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	28/51 (55%)
		PAS	102..215	CDD:279347	33/112 (29%)
		PAS	102..163	CDD:214512	21/60 (35%)
		PAS	278..376	CDD:238075	41/97 (42%)
		PAS_3	291..377	CDD:285623	37/85 (44%)
hif1al	XP_005157628.2	HLH	12..65	CDD:238036	27/49 (55%)
		PAS	91..147	CDD:214512	23/55 (42%)
		PAS	228..327	CDD:238075	41/98 (42%)
		PAS_11	231..332	CDD:291273	42/100 (42%)
		HIF-1	479..510	CDD:288296	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910