Protein Alignment sim and trh

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001261207.1
• Gene: trh / 38065
• FlyBaseID: FBgn0262139
• Length: 1022
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 238/905 - (26%)
• Similarity: 356/905 - (39%)
• Gaps: 307/905 - (33%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGE-AW- 88
            ||||::|||:||.|||.||.||||:|||||||||||||||:||||.||||:|..  .|.|: .|
  Fly    88 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWT 150

  Fly    89 --GSSPAMQRGATIK----------ELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVE 141
              .||.:..:.|.|:          ..|:|:||:||||...||.||:.:|||||.|::|||||||
  Fly   151 REASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVE 215

  Fly   142 LTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTH-------------TPIGSPNGVQHPS-- 191
            :||:|||:|||..|..|:         .:|..|:.|.             ...|:..|:..|:
  Fly   216 MTGSSIFDYIHQADHSEI---------ADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSG 271

  Fly   192 AYDHDRGSHTIE------------------IEKTFFLRMKCVLAKRNAGLTTSGFK----VIHC- 233
            |.|...|:|...                  .:::|.:|||..|.||.....:||::    ..:|
  Fly   272 ASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRASDATSNCN 336

  Fly   234 ----------------SGY----LKARIYPDR--GDGQGSLIQNLGLVAVGHSLPSSAITEIKLH 276
                            |.|    |..::.|..  ...:.|....||:||:..:||..::.||:|.
  Fly   337 NGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLE 401

  Fly   277 QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTK 341
            .:||:.|...|:::...:.|||.|..|.|:||:.|:||...||.|...:|.||..|:.||||.|.
  Fly   402 CDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHSDLIEKGQVLTG 466

  Fly   342 YYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLN--------------- 391
            |||.:.|.||:.|:|:.||:|.:::::.|..|:.||||:|.||.::::|:
  Fly   467 YYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDSIKHEE 531

  Fly   392 ----------------------------------------------------------------- 391
                                                                             
  Fly   532 GLGNDKSSGSPGGDASGEGNSHLSAGDMKLNSPKTDSEGHSHRGRGRSAAASHGSSMNSLTMIKD 596

  Fly   392 -------EIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQ 449
                   ||.:||:.....:|...|....|:.:..:..:|:|.|.    .|.|..|:.:|.:...
  Fly   597 SPTPLGVEIDSGVLPTTVATPVPAATPPVQSTKRKRKTKASQHAE----DQGQEQVISEQPLPKL 657

  Fly   450 PQCAGATGQP------VGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNNNG 508
            |.......||      :....|.|.|.||...|:......||...||..|.|.|...|:.:
  Fly   658 PTMEQRDQQPRSRLPSIVDEQPSSAADSAVKDLEQAMSKHLPSPAAVVSVAPPNTDFSADS---- 718

  Fly   509 VWHHHHVQQQQQSGSMDHDSLSYT----------------------QLYPPLNDLVVSSS----S 547
                 .::||||...:|.:..|.|                      |||.....::.:::    :
  Fly   719 -----LLKQQQQQQQLDPNEKSSTIQWIGTPYQQPPAPMPATALLRQLYANRESVIRATARQTPT 778

  Fly   548 SVGGG-----------------------------TASSAG--GGSSASASSSGVYSTEMQYPDTT 581
            .||.|                             :|:|.|  ||...||.:
  Fly   779 GVGPGVFYGDQQTGPLPTPPGSESSYENQYLQLHSAASGGHPGGQKTSADA-------------- 829

  Fly   582 TGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSES-----------------ERQLS 629
                 :.|....|..|.:::|...:|..|.|.:....:...::                 ..|.:
  Fly   830 -----FTNLVSTYGGYHSSIDYHNAMTPPSSVSPRDSNQPGKAAPVLASNGGYDYAPDPLRGQYA 889

  Fly   630 TGNASIVNETSPSQ--------------------TTYSDLSHNFELSYFSDNSSQQHQHQ 669
            |.:..:|..|.|.:                    .|||:|.   :..||:.:||....|:
  Fly   890 TSSGDVVPATLPLKPQASYTATMHPSGSTTTEGGVTYSNLD---QPQYFAPHSSFHLYHK 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	43/59 (73%)
		PAS	102..215	CDD:395786	49/145 (34%)
		PAS_3	291..377	CDD:430001	36/85 (42%)
trh	NP_001261207.1	bHLH-PAS_trachealess_like	83..152	CDD:381576	45/65 (69%)
		PAS	176..236	CDD:214512	35/68 (51%)
		PAS_3	415..502	CDD:430001	36/86 (42%)