Protein Alignment sim and Bmal2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_038963872.1
• Gene: Bmal2 / 362464
• RGDID: 620230
• Length: 625
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 133/592 - (22%)
• Similarity: 235/592 - (39%)
• Gaps: 145/592 - (24%)

  Fly    19 IAKTCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDG 83
            :|....::|......:.||:|.|....:|:.::|.......:|||.|::|....||:.::    |
  Rat    81 VAVPNGIREAHSQTEKRRRDKMNHLIWKLSSMIPPHIPTAHKLDKLSILRRAVQYLRSQR----G 141

  Fly    84 LGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSI 147
            :.|.:....|.......|||...:|:..:||:.||..: |:|:::|::.|..|...|..|.|.::
  Rat   142 MTEFYLGENAKPSFIQDKELSHLILKAAEGFLLVVGCEGGRILFVSKSVSKTLHYDQASLMGQNL 206

  Fly   148 FEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPN-----GVQHPSAYDHDR--------GS 199
            |:::...|..::...||....:.:       .|||:.:     .:..|..:.|..        ||
  Rat   207 FDFLQPKDVAKVKEQLSCDVSLRE-------KPIGTKSEFFLQSLASPQVHSHSHIGRSRVHSGS 264

  Fly   200 HTIEIEKTFFLRMK--CVLAKRNAGLTTS--------GFKVIHCSGYLKARIYP--------DRG 246
                 .::||.|||  |.:..:.....:|        .|..|||:|||  |.:|        :.|
  Rat   265 -----RRSFFFRMKSSCTVPVKEEQRCSSCSKKKDQRKFHTIHCTGYL--RSWPPNVVGTEKEMG 322

  Fly   247 DGQGSLIQNLG----LVAVGHSLPSSAIT---EIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYE 304
            .|:.|     |    |||:|...|.:...   :|.:....|:.|..::.|.::.|.|.:.:.||.
  Rat   323 SGKDS-----GPLTCLVAMGRLQPYTVPPKNGKINVRPAEFITRFAMNGKFVYVDQRATAILGYL 382

  Fly   305 PQDLIEKTLYQYIHAADIMAMRCSHQ-ILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSS 368
            ||:|:..:.|:|.|..|...:...|: :|..|.::.|..|:|..|.|.:|.::|......|..:.
  Rat   383 PQELLGTSCYEYFHQDDHSNLSDKHKAVLQSKEKILTDSYKFRVKDGSFVTLKSKWFSFTNPWTK 447

  Fly   369 REVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQA 433
            :..:|||||         .|||...:|.|     ..|..:::|:::                 .:
  Rat   448 KLEYIVSVN---------TLVLGRSETAV-----SVPQCRSSQSSE-----------------DS 481

  Fly   434 VQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNN 498
            .:...|.||..|          ||..:|.|   |:....:.::       |.||       .:::
  Rat   482 FRQPCVSVPGIS----------TGTLLGAG---SIGTDIANEV-------LSLQ-------RSHS 519

  Fly   499 SSSSSNNNNGVWHHHH--------------------VQQQQQSGSMDHDSLSYTQLYPPLNDLVV 543
            ||....|.:||....|                    .:.:....:..|.|......:.||    :
  Rat   520 SSPEDANPSGVVRDKHSVNFGSAPVPVSTGELFALSPETEGLEAARQHQSAEPAHCHKPL----L 580

  Fly   544 SSSSSVG 550
            |.|:.:|
  Rat   581 SDSTQLG 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	15/60 (25%)
		PAS	102..215	CDD:395786	31/128 (24%)
		PAS_3	291..377	CDD:430001	25/86 (29%)
Bmal2	XP_038963872.1	bHLH_SF	87..146	CDD:469605	16/62 (26%)
		PAS	171..268	CDD:238075	23/108 (21%)
		PAS_11	357..459	CDD:464214	30/110 (27%)