Protein Alignment sim and Met

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 695
• Identity: 138/695 - (19%)
• Similarity: 236/695 - (33%)
• Gaps: 185/695 - (26%)

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF---------P 81
            :|....|.:.||:|.|....|||.::|..|..:.:|||.:|:|..|..|:::.||         .
  Fly    38 REARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFGKSASRRRKK 102

  Fly    82 DGL-GEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGN 145
            .|| |....:||..........|...|:|.||.....:...|:|:.:|.:....||..|.:|.|.
  Fly   103 TGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLVSTSVEQLLGHCQSDLYGQ 167

  Fly   146 SIFEYIHNYDQD---------EMNAILSLHPHINQHPLAQTHTP--------------------- 180
            ::.:..|..|||         ::..:...|.|..|    |.|.|
  Fly   168 NLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQ----QGHNPQQHSTSTSASTSGSDLEEEEM 228

  Fly   181 ------IGSPNG-----VQHPSAYDH-----DRGSHTIEIEKTFFLRMKCVLAKRNAGLT----T 225
                  :|...|     ..||  |:.     .|.:|...|:....:..:|...:.....|    |
  Fly   229 ETEEHRLGRQQGEADDDEDHP--YNRRTPSPRRMAHLATIDDRLRMDRRCFTVRLARASTRAEAT 291

  Fly   226 SGFKVIHCSGYLK----------ARIYP------DRGDGQGSLIQNLGLVAVGHSLP--SSAITE 272
            ..::.:...|..:          |..||      .|......|.....:.|...::|  ..||.:
  Fly   292 RHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAAVAAEAATVPPQHDAIAQ 356

  Fly   273 IKLH----------------------------------------QNMFMFRAKLDMKLIFFDARV 297
            ..||                                        |..:..|..:|..:|..|.|:
  Fly   357 AALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEYHTRHLIDGSIIDCDQRI 421

  Fly   298 SQLTGYEPQDLIEKTLYQYIHAAD----IMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSY 358
            ..:.||...::...:.:.::|..|    |:|:|   |:...........||.|::.|.::::.:.
  Fly   422 GLVAGYMKDEVRNLSPFCFMHLDDVRWVIVALR---QMYDCNSDYGESCYRLLSRNGRFIYLHTK 483

  Fly   359 ATLVHNSRSSREVFIVSVNYVLSEREVKDLV--LNEIQTGVVKRE-------PISPAAQAAQAAQ 414
            ..|..:..|::....:.||.:|.|...:..|  :.|..:.::|.|       |..||:||.|..:
  Fly   484 GFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEKFSTIIKAEMPTQSSSPDLPASQAPQQLE 548

  Fly   415 AAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPY 479
            ...........::...|:.|..|    ..:|::     ......|....|...||.|.:|.|
  Fly   549 RIVLYLIENLQKSVDSAETVGGQ----GMESLM-----DDGYSSPANTLTLEELAPSPTPAL--- 601

  Fly   480 FEPELPLQPAVTPVPPTNNSSSSSNNNNGV-------WHHHHVQQQQQSGSMDHDSLSYTQLYPP 537
                     |:.|..|::..||.|.:.:.|       :...|.:|:::......:..:.||
  Fly   602 ---------ALVPPAPSSVKSSISKSVSVVNVTAARKFQQEHQKQRERDREQLKERTNSTQ---- 653

  Fly   538 LNDLVVSSSSSVGGGTASSA--GGGSSASASSSGVYSTEMQYPDT 580
              .::...||.:.....:|.  ...||.|||.:         |||
  Fly   654 --GVIRQLSSCLSEAETASCILSPASSLSASEA---------PDT 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	22/69 (32%)
		PAS	102..215	CDD:395786	31/158 (20%)
		PAS_3	291..377	CDD:430001	17/89 (19%)
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	18/50 (36%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	24/111 (22%)