Protein Alignment sim and Npas2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_038939510.1
• Gene: Npas2 / 316351
• RGDID: 1309681
• Length: 855
• Species: Rattus norvegicus
• Alignment Length: 776
• Identity: 161/776 - (20%)
• Similarity: 278/776 - (35%)
• Gaps: 183/776 - (23%)

  Fly    26 KEKSKNAARTRREKE-----NTEFCELAKLLPLPAAITSQLDKASVIRLTTSYL-KMRQVFPD-- 82
            |:::|.|:|.:.||:     |....||:.:||   ..|.:|||.:|:.....:| |..:|...
  Rat     6 KDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKLDKTTVLEKVIGFLQKHNEVSAQTE 67

  Fly    83 --GLGEAWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLG--------- 136
              .:.:.|  .|:........:|   :|:.||||:.||..||.|:|:|::.:..||
  Rat    68 ICDIQQDW--KPSFLSNEEFTQL---MLEALDGFVIVVTTDGSIIYVSDSITPLLGHLPGTEEES 127

  Fly   137 ------------------------------LSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQ 171
                                          |.|.::...::..::...:..|:..|||.|..:..
  Rat   128 MKGLHRSRTLRLCLRSEVHPVERASFSLYFLLQSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTD 192

  Fly   172 HPLAQ-----------THTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTT 225
            .|..:           .|...||.|..:.|: |::                :|.|...|:.....
  Rat   193 SPSPEFLKSDNDLEFYCHLLRGSLNPKEFPT-YEY----------------IKFVGNFRSYNNVP 240

  Fly   226 SGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLV--AVGHSLPSSAITEIKLHQNMFMFRAKLDM 288
            |.    .|:|:......|.|.. .|..:..:..|  |....|....:.:..|.:  |..|..|:.
  Rat   241 SP----SCNGFDNTLSRPCRVP-LGKEVCFIATVRLATPQFLKEMCVADEPLEE--FTSRHSLEW 298

  Fly   289 KLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWV 353
            |.:|.|.|...:.||.|.:::..:.|.|.|..|:..:...||.|:..|:..:..|||||||..|:
  Rat   299 KFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWI 363

  Fly   354 WVQSYATLVHNSRSSREVFIVSVNYVLSEREVK-----DLVLNEIQTGVVKREPISPAA------ 407
            |:|::..:.::..:|:..|||..:.|:|..:|:     :|.|.:..|     |.:.|:|
  Rat   364 WLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPT-----EAMHPSALKEKDS 423

  Fly   408 --------------QAAQAAQAAQAAQAAQAAQAAHVAQA----------VQAQVVVVPQQSVVV 448
                          .:...:..:.:|.:..:.:::|.|.:          .:.....:|:.:.:
  Rat   424 SLEPQPHFNALDMGASGLTSSPSPSASSRSSHKSSHTAMSEPTSTPTKLMAENSTTALPRSATL- 487

  Fly   449 QPQCAGATGQPVGPGTPVSLALSAS----PKLDPYFEPELPLQPAVTPVPPTNNSSSSSN----- 504
             ||.....|.......|..|..|:|    .:|.|...|:..||.  .|.|.|..|:..|.
  Rat   488 -PQELPVQGLSQAATMPAPLLSSSSCDLAKQLLPQSLPQTVLQS--PPAPVTQFSAQFSMFQTIK 549

  Fly   505 ----------NNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGG 559
                      ..|..|....:.:.|:...:..|  |..|::  |....||.|.|.....|:....
  Rat   550 DQLEQRTRILQANIRWQQEELHKIQEQLCLVQD--SNVQMF--LQQPAVSLSFSGAQRPAAQQPL 610

  Fly   560 GSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYD-----ATVDVATSMIRPFSANSNSC- 618
            ....||.|..........|...|....  .|.|...:.:     ....:.:|.:.|.|:.|.|.
  Rat   611 QQRPSAPSQPPLVVNTPLPGQITSTQV--TNQHLLRESNVMSAQGPKPIRSSQLLPASSRSLSSL 673

  Fly   619 -SSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHLMEQ 678
             |..|.:...|..|.:......:|..|:....|.:|             .|.:|.:.|:.|
  Rat   674 PSQFSSTASVLPPGLSLTTVAPTPQDTSQCQPSPDF-------------GHDRQLRLLLSQ 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	19/69 (28%)
		PAS	102..215	CDD:395786	30/162 (19%)
		PAS_3	291..377	CDD:430001	28/85 (33%)
Npas2	XP_038939510.1	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	20/75 (27%)
		PAS	84..234	CDD:395786	31/169 (18%)
		PAS_11	288..391	CDD:464214	33/104 (32%)