DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sim and Npas1

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001100949.1	Gene:	Npas1 / 308387	RGDID:	1310040	Length:	595	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	187/509 - (36%)
Similarity:	263/509 - (51%)	Gaps:	94/509 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVF-----PDGL- 84
            ||||:||||.||.|||.||.|||||||||.||:|||||||::||:.:||::|:..     |.||
  Rat    47 KEKSRNAARWRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLR 111

  Fly    85 --GEAWGSSPAMQRGATI-------KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQV 140
              |...|.:|. :|||..       :.||.|:||:||||:|.:..:||.:|||||.|::||||||
  Rat   112 AVGPPAGLAPG-RRGAVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQV 175

  Fly   141 ELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEI- 204
            ||||:|:|:|||..|..|:...|.|.        |.|..|...|:.....|:........|.||
  Rat   176 ELTGSSVFDYIHPGDHSEVLEQLGLR--------AATTGPPTPPSVSSTSSSSSSSSLVDTPEIE 232

  Fly   205 -------------EKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNL 256
                         |::||:|||..|.||...:..||:||||.:|.|:||.              |
  Rat   233 ASPTEASPAFRVQERSFFVRMKSTLTKRGLNVKASGYKVIHVTGRLRARA--------------L 283

  Fly   257 GLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAAD 321
            ||||:||:||.:.:.|:.||.:|.:||..|.:.::..::|||......|.:|:.::.||::|..|
  Rat   284 GLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSCYQFVHGQD 348

  Fly   322 IMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVK 386
            :..:|.||..||.||||.|.|||:|.:.||:||:||.||:..|.:|:.|..::.|::|||..|..
  Rat   349 VTRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSAGEHHVLWVSHVLSHAEGG 413

  Fly   387 DLVLNEIQTGVV--KREPISPAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVP-QQSVVV 448
            ...|:..|...:  :.|..||..:..:.....:..|                   .|| :|....
  Rat   414 QTPLDAFQLPAIVSQEESSSPGPEPTKEEPPVERKQ-------------------TVPVEQDKDK 459

  Fly   449 QPQCAGATGQPVGPGTPVSLALSASPK---------LDPYFEPELPLQPAVTPV 493
            .||..|.           .:.:.||||         .:...:|..|.:|..|.|
  Rat   460 DPQARGK-----------RIKVEASPKEVRGSEDSGEEEVSDPPAPPRPEFTSV 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	37/51 (73%)
		PAS	102..215	CDD:279347	51/126 (40%)
		PAS	102..163	CDD:214512	35/60 (58%)
		PAS	278..376	CDD:238075	38/97 (39%)
		PAS_3	291..377	CDD:285623	34/85 (40%)
Npas1	NP_001100949.1	bHLH-PAS_NPAS1_PASD5	43..116	CDD:381574	42/68 (62%)
		PAS	141..198	CDD:214512	33/56 (59%)
		PAS_3	317..388	CDD:369881	30/70 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820