Protein Alignment sim and ahr2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_571339.1
• Gene: ahr2 / 30517
• ZFINID: ZDB-GENE-990714-16
• Length: 1027
• Species: Danio rerio
• Alignment Length: 760
• Identity: 169/760 - (22%)
• Similarity: 280/760 - (36%)
• Gaps: 203/760 - (26%)

  Fly    22 TCAMKEKSK----------------NAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLT 70
            |.|:|::.|                |.::..|::.|:|..:|..|||....:.::|||.||:||:
Zfish     7 TYAVKKRKKPVQKIPKPPPPDGVKSNPSKRHRDRLNSELDKLTNLLPFSEDVRARLDKLSVLRLS 71

  Fly    71 TSYLKMRQVFPDGL----GEAW-----------GSSPAMQRGATIKELGSHLLQTLDGFIFVVAP 120
            ..|||::..|...:    |..|           |.:.:...|....| |..|||.|:||:.||..
Zfish    72 VGYLKVKSFFNATIKKTGGNGWLNDRSGTFGGNGQTASSLDGVNFSE-GELLLQALNGFVLVVTA 135

  Fly   121 DGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPN 185
            :|.:.|.|.|...:||..|.::..:|:||.||..|:    |:.....|...:|  .:.:..|| .
Zfish   136 EGYVFYSSPTIQDYLGFHQSDVVHHSVFELIHTDDR----AMFRRQLHFALNP--SSDSADGS-E 193

  Fly   186 GVQHPSAYDHDRGSHTIE---------IEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARI 241
            .:|..|....|..::..:         :|::|..|.:|:|.      .:|||..::..|.||..
Zfish   194 AMQSSSDITRDMVNYNPQHIPPENSSFLERSFCCRFRCLLD------NSSGFLALNFQGRLKYL- 251

  Fly   242 YPDRGDGQGSLIQN-------LGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQ 299
                 .||..|.::       |.|..:...|...:|.||:....:|..:.|||...:..|.|...
Zfish   252 -----HGQNKLAEDGTLAHPQLALFIIATPLQPPSILEIRSKTLLFQTKHKLDFTPMGIDTRGKV 311

  Fly   300 LTGYEPQDL-IEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVH 363
            :.||...:| :..:.||:|||||:|....:|..::..|:.....:|.|:|||.|:|||:.|.||:
Zfish   312 VLGYTEIELCMRGSGYQFIHAADMMYCADNHIRMIKTGESGLTVFRLLSKGGTWIWVQANARLVY 376

  Fly   364 NSRSSREVFIVSVNYVLSEREVKD--------------------------LVLNEIQTGVVKREP 402
              ::.|..||::....|:..|.::                          |.:.|||.....::.
Zfish   377 --KAGRPDFIIARQRALTNEEGEEHLRQRKLQLPFNCATGEGVLYEVGPTLDVAEIQNQSKGQKM 439

  Fly   403 ISPAAQAAQAAQAAQAAQ----------------AAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQ 451
            ::|.:....:...:...|                ..:|...:|.       ::.||
Zfish   440 LNPPSLDPDSLLGSMLKQDHSLYSQNNDPNSQFTIDKAFGDSHA-------LLNVP--------- 488

  Fly   452 CAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPVPPTNNSSSSSNNN---------- 506
              |.|.||..|.|...:...|..| |       .|:.....:...||.:|..:.|
Zfish   489 --GNTWQPSTPNTVPGIKEEAVVK-D-------MLETLQQIIEVGNNCNSLEDFNLDRMELKEWE 543

  Fly   507 NGVWHHHHVQQQQQSGSMDHDSLSYTQ--LY-----PPLNDLVVSSSSSVG-------------- 550
            |.:...::....:.:..:..|..||.:  |:     .||.||...|..|.|
Zfish   544 NTLCRMNYNNDMEINEIITEDIFSYVEDVLFKENGIQPLKDLGPFSEMSEGLSELELQNNLAANQ 608

  Fly   551 ---------GGTASSAG-------GGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDA 599
                     ||:....|       .|...|:...|........|....||.:..:     :..|.
Zfish   609 EFSCQAGVHGGSPGQGGFIGMNIQEGMDTSSPGRGTVKLSHMGPQMLPGNNFIQS-----FGLDQ 668

  Fly   600 TVDVATSMIRPFSANSN------SCSSSSESERQLSTGNASIVNE 638
            |.       :..:.|||      .....|:...|::.|...:|.|
Zfish   669 TT-------QKMAGNSNILFRPSLAMQQSQQPNQVNLGLQGVVQE 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	21/80 (26%)
		PAS	102..215	CDD:395786	34/121 (28%)
		PAS_3	291..377	CDD:430001	30/86 (35%)
ahr2	NP_571339.1	bHLH-PAS_AhR_like	27..85	CDD:381539	19/57 (33%)
		PAS	120..183	CDD:214512	23/66 (35%)
		PAS_3	312..386	CDD:430001	28/75 (37%)
		Med15	<600..>832	CDD:312941	19/119 (16%)