Protein Alignment sim and Sim2

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_001100578.1
• Gene: Sim2 / 304071
• RGDID: 1308016
• Length: 656
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 280/544 - (51%)
• Similarity: 333/544 - (61%)
• Gaps: 94/544 - (17%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWG 89
            |||||||||:|||||||.||.|||||||||:||||||||||:|||||||||||.|||:|||:|||
  Rat     1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWG 65

  Fly    90 S-SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHN 153
            . |......:..||||||||||||||:||||.|||||||||||||||||||||||||||:||||.
  Rat    66 QPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHP 130

  Fly   154 YDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAK 218
            .|.|||.|:|:.||.::.|.|.:                         .|||::|||||||||||
  Rat   131 SDHDEMTAVLTAHPPLHHHLLQE-------------------------YEIERSFFLRMKCVLAK 170

  Fly   219 RNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFR 283
            ||||||.||:||||||||||.|.|........|..|.:||||||.|||.|||||||||.||||||
  Rat   171 RNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHNNMFMFR 235

  Fly   284 AKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTK 348
            |.||:||||.|:||::|||||||||||||||.::|..|...:|.:|.:||.||||||||||.|:|
  Rat   236 ASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSK 300

  Fly   349 GGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVK-----REPISPAAQ 408
            .|||||||||||:||||||||...||||||||:|.|.|:|.|:..|....|     |..:|.:.:
  Rat   301 LGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEVEYKELQLSLDQVSTSKSQESWRTTLSTSQE 365

  Fly   409 AAQAAQ--------------------AAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSV------- 446
            ..::|:                    ::......:.:||.:...:.....|..|:|.:
  Rat   366 TRKSAKPKTTKMRTKLRTNPYPSQQYSSFQMDKLECSQAGNWRTSPPTSAVAPPEQQLHSEASDL 430

  Fly   447 -------------------------VVQPQCAGATGQPVGPGTPVSLA------LSASPKLDPYF 480
                                     ..:|......|||  .|:|..:|      |.||.:...::
  Rat   431 LYGPPYSLPFSYRYGHFPLDSHVFSSKKPGLPAKFGQP--QGSPCEVARFFLSTLPASSECQWHY 493

  Fly   481 EPELPLQPAVTPVPPTNNSSSSSN 504
            ...  |.|: :|.|..|.|.|..|
  Rat   494 ANS--LMPS-SPSPAKNLSESPVN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	53/60 (88%)
		PAS	102..215	CDD:395786	67/112 (60%)
		PAS_3	291..377	CDD:430001	60/85 (71%)
Sim2	NP_001100578.1	bHLH_SF	1..74	CDD:469605	58/72 (81%)
		PAS	79..140	CDD:214512	53/60 (88%)
		PAS_11	91..194	CDD:464214	79/127 (62%)
		PAS_3	243..329	CDD:430001	60/85 (71%)
		SIM_C	358..649	CDD:461963	25/162 (15%)