DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sim and Npas3

DIOPT Version :9

Sequence 1:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_036013330.1	Gene:	Npas3 / 27386	MGIID:	1351610	Length:	1247	Species:	Mus musculus

Alignment Length:	733	Identity:	222/733 - (30%)
Similarity:	334/733 - (45%)	Gaps:	182/733 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDG------- 83
            ||||::|||:||.|||.||.||||||||||||||||||||:||||.||||||.....|
Mouse   362 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLR 426

  Fly    84 ----------LG-EAWGSSPAMQR------GATIK-------------ELGSHLLQTLDGFIFVV 118
                      .| :.|.|...|::      ||..:             .||||:||:||||:|.:
Mouse   427 MEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFAL 491

  Fly   119 APDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPL--------- 174
            ..:||.:|||||.|::||||||||||:|:|:|:|..|..||...|.:.....:..|
Mouse   492 NQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAA 556

  Fly   175 ------AQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHC 233
                  :|:.||  .|.....||....|.     .:|::||:|||..|.||...:.:||:||||.
Mouse   557 SSASSSSQSETP--EPVETTSPSLLTTDN-----TLERSFFIRMKSTLTKRGVHIKSSGYKVIHI 614

  Fly   234 SGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVS 298
            :|.|:.|:....|....|  |.:|||.|.|:||...|.|:::..:||:.|..:|:.:|:.:.|:|
Mouse   615 TGRLRLRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 677

  Fly   299 QLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVH 363
            ......|.|::.|..|.:|||.|:..:|.||..||.|||..|||||::.|.||::|:||.||:..
Mouse   678 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAI 742

  Fly   364 NSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISPAAQAAQAAQAAQAAQAAQAAQAA 428
            |::::.|..|:.|||:||..|.||..::      :.:.|..|    .:|:::::.:.:...::
Mouse   743 NAKNANEKNIIWVNYLLSNPEYKDTPMD------IAQLPHLP----EKASESSETSDSESDSK-- 795

  Fly   429 HVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLALSASPKLDPYFEPELPLQPAVTPV 493
                                  ..:|.|.:.           :.:.|.|   |.....:.:..|.
Mouse   796 ----------------------DTSGITAED-----------NENSKSD---EKGNQSENSEDPE 824

  Fly   494 PPTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPP---------LNDLVV------ 543
            |....|.|:.:|:.......|......|...| ||..::....|         |..:.:
Mouse   825 PDRKKSGSACDNDMNCNDDGHSSSNPDSRDSD-DSFEHSDFEHPKAAEDGFGALGPMQIKVERYV 888

  Fly   544 ---------------------SSSSSVGGGTASS------------AGGGSS----ASASSSGVY 571
                                 |.|::..|..|||            .||.:|    :||||.|:.
Mouse   889 ESEADLRLQPCESLTSDSAKDSDSANEAGAQASSKHQKRKRRRKRQKGGSASRRRLSSASSPGLD 953

  Fly   572 STEMQYPDTTTGNLYYNNNNHYYYDYDATV-DVATSMIRPFSANSNSCSSSSESERQLSTGNASI 635
            :..::.|...:.            .:.|:| .:.|.:..|.:.:::|...:....|::|.
Mouse   954 AGLVEPPRLLSS------------PHSASVLKIKTEIAEPINFDNDSSIWNYPPNREISR----- 1001

  Fly   636 VNETSPSQTTYSDLSHNF 653
             || ||...|....|.:|
Mouse  1002 -NE-SPYSMTKPPTSEHF 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	43/51 (84%)
		PAS	102..215	CDD:279347	51/127 (40%)
		PAS	102..163	CDD:214512	36/60 (60%)
		PAS	278..376	CDD:238075	39/97 (40%)
		PAS_3	291..377	CDD:285623	35/85 (41%)
Npas3	XP_036013330.1	bHLH-PAS_NPAS3_PASD6	357..433	CDD:381575	45/70 (64%)
		PAS	478..536	CDD:214512	34/57 (60%)
		PAS_3	669..756	CDD:369881	35/86 (41%)
		MSCRAMM_ClfA	<762..>922	CDD:411231	27/208 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D393498at33208
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850