Protein Alignment sim and sim1a

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_835740.2
• Gene: sim1a / 260351
• ZFINID: ZDB-GENE-020829-1
• Length: 745
• Species: Danio rerio
• Alignment Length: 796
• Identity: 325/796 - (40%)
• Similarity: 398/796 - (50%)
• Gaps: 211/796 - (26%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWG 89
            |||||||||||||||||:||.|||||||||:||||||||||:|||||||||||.|||:||||:||
Zfish     1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESWG 65

  Fly    90 SSPAMQRGATI----KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEY 150
            .   :.|..::    :|||||||||||||||||||||||:||||||||||||||||||||||:||
Zfish    66 H---VSRTTSLENVGRELGSHLLQTLDGFIFVVAPDGKILYISETASVHLGLSQVELTGNSIYEY 127

  Fly   151 IHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCV 215
            ||..|.|||.|:|:.|...:.|.:                         |..|:|::||||||||
Zfish   128 IHPADHDEMTAVLTAHQPYHSHFV-------------------------HEYEMERSFFLRMKCV 167

  Fly   216 LAKRNAGLTTSGFKVIHCSGYLKARIYP-DRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNM 279
            |||||||||..|:||||||||||.|.|. |.....| ..||:||||||||||.||:||||||.||
Zfish   168 LAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG-CYQNVGLVAVGHSLPPSAVTEIKLHSNM 231

  Fly   280 FMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYR 344
            |||||.|||||||.|:||::|||||||||||||||.::|:.|...:||:|.:||.||||||||||
Zfish   232 FMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAHHLLLVKGQVTTKYYR 296

  Fly   345 FLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVK-----REPIS 404
            ||.|.|||||||||||:||||||||...||||||||::.|.|.|.|:..|....|     ..|.:
Zfish   297 FLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQAASTKPSFTYNSPSN 361

  Fly   405 PAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQ--PVGPGTPVS 467
            |..:..:..::.              ....:.:..:.|.......|.....:.|  |.| |:|
Zfish   362 PVTENRRVGKSR--------------VSRTKTKTRLSPYSQYPGFPTDRSESDQDSPWG-GSP-- 409

  Fly   468 LALSASPKL-------------DPYFEPE-----LPL---------------------------- 486
            |..||||:|             ..:.:|.     |||
Zfish   410 LTDSASPQLLEQCEGIESSCVYRQFSDPRSLCYGLPLTEDHHTSNELYSHPHSESCERGCCKAGR 474

  Fly   487 ------QP----------AVTPVPPTNNSSSSSNNNNGVWHH-HHVQQQQQSGSMDHDSLSYTQL 534
                  ||          :|.|:|  .:|..:.::..||..| ..:...|..|..|.|
Zfish   475 YFLGTPQPGREAWWGAARSVLPLP--KSSPENGDSFEGVMPHIASIHSLQVRGHWDED------- 530

  Fly   535 YPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSG----------VYSTEMQY------------ 577
                     |:.||..||:||.:|....|....|.          :.:|:...
Zfish   531 ---------SAVSSPDGGSASDSGDRFRADQCRSSPQEPSKIETLIRATQQMIKEEESRLQLRKL 586

  Fly   578 -------PDTTTGNLYYNNNNHYYYDYDATVDVA----TSMIRPFSANSNSCSSSSESERQLSTG 631
                   |..:....:::.:    :...|...|.    ..:|.|..:.......||....:||.|
Zfish   587 PTDVPLEPTNSLAKSFHSTD----FPQSAMQSVVCRGPAQVISPAPSPVPLSRLSSPLPDRLSKG 647

  Fly   632 NASIVNETSPSQ--------------------------------TTYSDLSHNFELSYFSDNS-- 662
            ...:.||.|.||                                |:|: |.|.:|...|...|
Zfish   648 KDFLQNELSSSQLPLTGTCAVSPTPALYSLHPRQYLEKHAAYSLTSYA-LEHLYEADSFRGYSLG 711

  Fly   663 SQQHQHQQQQQHLMEQ 678
            .....|.....||..|
Zfish   712 CSGSSHYDMTTHLRMQ 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	54/60 (90%)
		PAS	102..215	CDD:395786	66/112 (59%)
		PAS_3	291..377	CDD:430001	62/85 (73%)
sim1a	NP_835740.2	bHLH-PAS_SIM1	1..71	CDD:381581	59/72 (82%)
		PAS	88..>158	CDD:238075	50/94 (53%)
		PAS_3	243..329	CDD:430001	62/85 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..413		11/79 (14%)
		SIM_C	358..647	CDD:461963	52/327 (16%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		1/32 (3%)