DRSC/TRiP Functional Genomics Resources

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Protein Alignment sim and Ahr

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_037281.3 Gene:Ahr / 25690 RGDID:2074 Length:853 Species:Rattus norvegicus


Alignment Length:705 Identity:175/705 - (24%)
Similarity:283/705 - (40%) Gaps:159/705 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 NAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGSSPA-M 94
            |.::..|::.|||...||.|||.|..:.|:|||.||:||:.|||:.:..|...|    .|:|| .
  Rat    33 NPSKRHRDRLNTELDRLASLLPFPQDVISKLDKLSVLRLSVSYLRAKSFFDVAL----KSTPADR 93

  Fly    95 QRG-----ATIKEL-----GSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFE 149
            .||     |.:::.     |..|||.|:||:.||..|..:.|.|.|...:||..|.::...|::|
  Rat    94 SRGQDQCRAQVRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYE 158

  Fly   150 YIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAY---DHDRGSHTIEIEKTFFLR 211
            .||..|:.|...  .||..:|......:...:...:|:..|:.|   |.....:|..:|:.|..|
  Rat   159 LIHTEDRAEFQR--QLHWALNPSQCTDSAQGVDETHGLPQPAVYYTPDQLPPENTAFMERCFRCR 221

  Fly   212 MKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLI-QNLGLVAVGHSLPSSAITEIKL 275
            ::|:|.      .:|||..::..|.||.....::....|:|: ..|.|.|:...|...:|.||:.
  Rat   222 LRCLLD------NSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRT 280

  Fly   276 HQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEK-TLYQYIHAADIMAMRCSHQILLYKGQVT 339
            ...:|..:.|||...|..||:...:.||...:|..| :.||:|||||::....||..::..|:..
  Rat   281 KNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQFIHAADMLHCAESHIRMIKTGESG 345

  Fly   340 TKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPIS 404
            ...:|.|.|...|.||||.|.|::  |:.|..:|::....|::.|.::                 
  Rat   346 MTVFRLLAKHSRWRWVQSNARLIY--RNGRPDYIIATQRPLTDEEGRE----------------- 391

  Fly   405 PAAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLA 469
                                    |    :|.:.:.:|...         |||:.|         
  Rat   392 ------------------------H----LQKRSMTLPFMF---------ATGKAV--------- 410

  Fly   470 LSASPKLDPYFEPELPLQPAVTPVPPTNNSSSS-------SNNNNGVWHHHHVQQQQQSGSMDHD 527
                     .:|...|..|.:.|:|....|::|       |..:...:|.:.:    .|..:..|
  Rat   411 ---------LYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPNSL----MSALIQQD 462

  Fly   528 SLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYS-TEMQYPD----TTTG---N 584
            ...|  |.||.:...:.|...:...:...:..||.|:||:..:.. .|:::..    |.:|   .
  Rat   463 ESIY--LCPPSSPAPLDSHFLMDSMSECGSWQGSFAAASNEALLKHEEIRHTQDVNLTLSGGPSE 525

  Fly   585 LYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDL 649
            |:.:|.|:..|.....:.:....||                   |..|.......|..:..:.|:
  Rat   526 LFPDNKNNDLYSIMRNLGIDFEDIR-------------------SMQNEEFFRTDSSGEVDFKDI 571

  Fly   650 SHNFE-LSYFSD---NSSQQHQHQQQQ---QHLM----------EQQHLQYQYAT 687
            ....| |:|..|   ||:..:...|||   |||.          :||.||.|:.|
  Rat   572 DITDEILTYVQDSLNNSTLLNSACQQQPVSQHLSCMLQERLQLEQQQQLQQQHPT 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 24/54 (44%)
PAS 102..215 CDD:395786 33/120 (28%)
PAS_3 291..377 CDD:430001 30/86 (35%)
AhrNP_037281.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 1/4 (25%)
Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869 12..15
bHLH-PAS_AhR 27..87 CDD:381442 24/57 (42%)
Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869 36..41 1/4 (25%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869 37..65 12/27 (44%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869 49..81 17/31 (55%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869 63..71 5/7 (71%)
PAS 111..>181 CDD:395786 25/71 (35%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 116..124 5/7 (71%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 264..266 0/1 (0%)
PAS_3 295..380 CDD:430001 30/86 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..451 3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

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