DRSC/TRiP Functional Genomics Resources

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Protein Alignment sim and Arnt

DIOPT Version :10

Sequence 1:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_036912.3 Gene:Arnt / 25242 RGDID:2153 Length:809 Species:Rattus norvegicus


Alignment Length:746 Identity:170/746 - (22%)
Similarity:279/746 - (37%) Gaps:159/746 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90
            :|......|.||.|......||:.::|..:|:..:.||.:::|:..|::|..:    |.|.....
  Rat    91 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLR----GTGNTSTD 151

  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154
            ........|.:||...:|:..|||:|:|:.: |:::|:|::.:..|...|.|..|:::::.:|..
  Rat   152 GSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPD 216

  Fly   155 DQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSH---------------TIEI 204
            |.|::...||...:.....:....|......|.|  |:.....||.               .:.:
  Rat   217 DVDKLREQLSTSENALTGRILDLKTGTVKKEGQQ--SSMRMCMGSRRSFICRMRCGTSSVDPVSM 279

  Fly   205 EKTFFLRMKCVLAKRNAGLTTSG---FKVIHCSGYLKARIYPDRG---------DGQGSLIQNLG 257
            .:..|||.:|   :...|....|   |.|:||:||:||  :|..|         .||||   ...
  Rat   280 NRLSFLRNRC---RNGLGSVKEGEPHFVVVHCTGYIKA--WPPAGVSLPDDDPEAGQGS---KFC 336

  Fly   258 LVAVGH----SLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIH 318
            |||:|.    |.|:............|:.|..::....|.|.|.....||:||:|:.|.:.::.|
  Rat   337 LVAIGRLQVTSSPNCTDMSNICQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCH 401

  Fly   319 AADIMAMRCS-HQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIV--SVNYVL 380
            ..|...:|.| .|::..||||.:..:||..|...|:|:::.:....|..|....:|:  :.|...
  Rat   402 PEDQQLLRDSFQQVVKLKGQVLSVMFRFRAKNREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKN 466

  Fly   381 SEREVKDLVLNEIQTGVVKREPISPAAQ-----------AAQAAQAAQAAQAAQAAQAAHVAQAV 434
            |.:|.:..:.|.||     |..:.|...           :.|..|..|..|..|..|.....|..
  Rat   467 SSQEPRPTLSNTIQ-----RSQLGPTTNLSLEMGTGQLASRQQQQQQQQQQQQQQQQQQQQQQQQ 526

  Fly   435 QAQVVVVPQQSVVVQPQCAGATGQPVG-PGTPVSLALSASPKL-----DPYFEPELP-------- 485
            |.::.:||.:..:.....:..:.|||. .|:..|..|..|..|     ||.|....|        
  Rat   527 QTELDMVPGRDGLASYSHSQVSVQPVATAGSEHSKPLEKSEGLFVQDRDPRFSEIYPNISADQSK 591

  Fly   486 -LQPAVTPVP----------PTNNSSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLN 539
             |..:..|..          |.|...:.:..|:|                         |.||:.
  Rat   592 GLSSSTVPATQQLFSQGSSFPPNPRPAENFRNSG-------------------------LTPPVT 631

  Fly   540 DLVVSSSSSVGGGTA-----SSAGGGSSASASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDA 599
              :|..|||.|...|     |:...||:.:.:||.......|.|...|                 
  Rat   632 --IVQPSSSAGQILAQISRHSNLTQGSAPTWTSSTRPGFSAQLPTQAT----------------- 677

  Fly   600 TVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNF------ELSYF 658
                |.:....|..|:...|||..:   :|...|...:.::.:..|..:...||      ....|
  Rat   678 ----AKTRSSQFGVNNFQTSSSFSA---MSLPGAPTASPSTAAYPTLPNRGSNFPPETGQTTGQF 735

  Fly   659 SDNSSQ----QHQHQQQQQH---LMEQQHLQ 682
            ...:::    ..|.|.||.|   ...:||:|
  Rat   736 QTRTAEGVGVWPQWQGQQPHHRSSSNEQHVQ 766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 15/59 (25%)
PAS 102..215 CDD:395786 29/128 (23%)
PAS_3 291..377 CDD:430001 26/88 (30%)
ArntNP_036912.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..95 1/3 (33%)
bHLH-PAS_ARNT 86..150 CDD:381517 16/62 (26%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762 88..128 9/36 (25%)
Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762 112..264 37/157 (24%)
Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762 112..168 13/59 (22%)
PAS 163..269 CDD:395786 26/107 (24%)
Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762 167..171 1/3 (33%)
PAS_11 362..462 CDD:464214 28/99 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..487 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..575 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..685 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..735 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..809 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

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