Protein Alignment sim and Sim2

DIOPT Version :9

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_006523029.1
• Gene: Sim2 / 20465
• MGIID: 98307
• Length: 661
• Species: Mus musculus
• Alignment Length: 592
• Identity: 291/592 - (49%)
• Similarity: 345/592 - (58%)
• Gaps: 113/592 - (19%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPD----GLG 85
            |||||||||:|||||||.||.|||||||||:||||||||||:|||||||||||.|||:    |||
Mouse     1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGEAAGLG 65

  Fly    86 EAWGS-SPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFE 149
            :|||. |......:..||||||||||||||:||||.|||||||||||||||||||||||||||:|
Mouse    66 DAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYE 130

  Fly   150 YIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKC 214
            |||..|.|||.|:|:.||.::.|.|.:                         .|||::|||||||
Mouse   131 YIHPSDHDEMTAVLTAHPPLHHHLLQE-------------------------YEIERSFFLRMKC 170

  Fly   215 VLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNM 279
            ||||||||||.||:||||||||||.|.|........|..|.:||||||.|||.|||||||||.||
Mouse   171 VLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNM 235

  Fly   280 FMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYR 344
            |||||.||:||||.|:||::|||||||||||||||.::|..|...:|.:|.:||.||||||||||
Mouse   236 FMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYR 300

  Fly   345 FLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVK-----REPIS 404
            .|:|.|||||||||||:||||||||...||||||||::.|.|:|.|:..|....|     |..:|
Mouse   301 LLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTSKSQESWRTTLS 365

  Fly   405 PAAQAAQAAQAAQAAQAA--------------------QAAQAAHVAQAVQAQVVVVPQQSVVVQ 449
            .:.:..::|:........                    :.:|..:...:.....|..|:|.:..:
Mouse   366 TSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQQLHSE 430

  Fly   450 PQCAGATGQPVGPGTPVSLALS---ASPKLDPYF----EPELPL---QPAVTPVP------PTNN 498
                 |:....||  |.||..|   ....||.:.    :|.||.   ||..:|..      .|..
Mouse   431 -----ASDLLYGP--PYSLPFSYHYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLP 488

  Fly   499 SSSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSA 563
            :||...     ||                         ..|.||.||||     .|.:....|..
Mouse   489 ASSECQ-----WH-------------------------CANSLVPSSSS-----PAKNLSEPSPV 518

  Fly   564 SASSSGV 570
            :|:..|:
Mouse   519 NAARHGL 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	HLH	26..78	CDD:238036	46/51 (90%)
		PAS	102..215	CDD:279347	67/112 (60%)
		PAS	102..163	CDD:214512	53/60 (88%)
		PAS	278..376	CDD:238075	70/97 (72%)
		PAS_3	291..377	CDD:285623	60/85 (71%)
Sim2	XP_006523029.1	bHLH_SF	1..78	CDD:381792	58/76 (76%)
		PAS	83..144	CDD:214512	53/60 (88%)
		PAS_3	247..333	CDD:369881	60/85 (71%)
		SIM_C	363..654	CDD:369005	37/205 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4769
eggNOG	1	0.900	-	-		E1_KOG3558
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1478
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000232
OrthoInspector	1	1.000	-	-		otm44346
orthoMCL	1	0.900	-	-		OOG6_106200
Panther	1	1.100	-	-	O	PTHR23043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2563
SonicParanoid	1	1.000	-	-		X501
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850