Protein Alignment sim and Sim1

DIOPT Version :10

• Sequence 1: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: XP_006512689.1
• Gene: Sim1 / 20464
• MGIID: 98306
• Length: 801
• Species: Mus musculus
• Alignment Length: 773
• Identity: 318/773 - (41%)
• Similarity: 387/773 - (50%)
• Gaps: 211/773 - (27%)

  Fly    25 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPD------- 82
            |||||||||||||||||:||.|||||||||:||||||||||:|||||||||||.|||:
Mouse     1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEVRCKFRM 65

  Fly    83 -----------------------------GLGEAWG----SSPAMQRGATIKELGSHLLQTLDGF 114
                                         |||||||    :||....|   :|||||||||||||
Mouse    66 QTPGFLRYSLMGPGISRRKETDSNNSDYLGLGEAWGHTSRTSPLDNVG---RELGSHLLQTLDGF 127

  Fly   115 IFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHT 179
            |||||||||||||||||||||||||||||||||:||||..|.|||.|:|:.|...:.|.:.:
Mouse   128 IFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQE--- 189

  Fly   180 PIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYP- 243
                                  .|||::|||||||||||||||||..|:||||||||||.|.|.
Mouse   190 ----------------------YEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSL 232

  Fly   244 DRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDL 308
            |.....| ..||:||||||||||.||:||||||.|||||||.|||||||.|:||::|||||||||
Mouse   233 DMSPFDG-CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDL 296

  Fly   309 IEKTLYQYIHAADIMAMRCSHQILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFI 373
            ||||||.::|..|...:||:|.:||.||||||||||||.|.|||||||||||:||||||||...|
Mouse   297 IEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCI 361

  Fly   374 VSVNYVLSEREVKDLVLNEIQTGVVK---------REPISPAAQAAQAAQAAQAAQA-------- 421
            |||||||::.|.|.|.|:..|....|         ...||...:.|::..::..:::
Mouse   362 VSVNYVLTDTEYKGLQLSLDQISASKPTFSYTSSSTPTISDNRKGAKSRLSSSKSKSRTSPYPQY 426

  Fly   422 ----AQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLA------------- 469
                .:.:::.|.:|...:.:      :....||..    .|..||:...|:
Mouse   427 SGFHTERSESDHDSQWGGSPL------TDTASPQLL----DPERPGSQHELSCAYRQFPDRSSLC 481

  Fly   470 --------------------------------LSASPK-LDPYF--EPELPLQPAVTPVPPTNNS 499
                                            |.|.|. .||::  ...|||..|        :.
Mouse   482 YGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPTGRDPWWGSRAALPLTKA--------SP 538

  Fly   500 SSSSNNNNGVWHHHHVQQQQQSGSMDHDSLSYTQLYPPLNDLVVSSSSSVGGGTASSAGGGSSAS 564
            .|.....|.:.|...:.:....|..|.||             ||||...   |:||.:|..
Mouse   539 ESREAYENSMPHITSIHRIHGRGHWDEDS-------------VVSSPDP---GSASESGDR---- 583

  Fly   565 ASSSGVYSTEMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLS 629
                  |.||.           |.|:.|.....:..:.....||:   ...|..........||:
Mouse   584 ------YRTEQ-----------YQNSPHEPSKIETLIRATQQMIK---EEENRLQLRKAPPDQLA 628

  Fly   630 TGNAS-------IVNETSPSQTTYSDLSHNFELSYFSDNSSQQHQHQQQQQHLMEQQH 680
            :.|.:       ..|...|..|  .::.|:..|:     |:....|.||::..|...|
Mouse   629 SINGAGKKHSLCFANYQQPPPT--GEVCHSSALA-----STSPCDHIQQREGKMLSPH 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	54/96 (56%)
		PAS	102..215	CDD:395786	67/112 (60%)
		PAS_3	291..377	CDD:430001	62/85 (73%)
Sim1	XP_006512689.1	bHLH-PAS_SIM1	1..107	CDD:381581	59/105 (56%)
		PAS	124..>194	CDD:238075	51/94 (54%)
		PAS_3	279..365	CDD:430001	62/85 (73%)
		SIM_C	395..704	CDD:461963	58/350 (17%)